SRB4D_HUMAN
ID SRB4D_HUMAN Reviewed; 575 AA.
AC Q8WTU2; Q2HIZ5; Q6ZMG3; Q96BF5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Scavenger receptor cysteine-rich domain-containing group B protein {ECO:0000303|PubMed:12466895, ECO:0000312|HGNC:HGNC:14461};
DE AltName: Full=Four scavenger receptor cysteine-rich domains-containing protein {ECO:0000312|HGNC:HGNC:14461};
DE AltName: Full=S4D-SRCRB {ECO:0000303|PubMed:12466895};
DE Flags: Precursor;
GN Name=SSC4D {ECO:0000312|HGNC:HGNC:14461};
GN Synonyms=SRCRB4D {ECO:0000312|EMBL:EAW71806.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAC84764.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND INDUCTION.
RX PubMed=12466895; DOI=10.1007/s00251-002-0507-z;
RA Padilla O., Pujana M.A., Lopez-de la Iglesia A., Gimferrer I., Arman M.,
RA Vila J.M., Places L., Vives J., Estivill X., Lozano F.;
RT "Cloning of S4D-SRCRB, a new soluble member of the group B scavenger
RT receptor cysteine-rich family (SRCR-SF) mapping to human chromosome
RT 7q11.23.";
RL Immunogenetics 54:621-634(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAD18764.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hepatoma {ECO:0000269|PubMed:14702039};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4] {ECO:0000312|EMBL:EAW71806.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305, ECO:0000312|EMBL:AAI13841.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain {ECO:0000312|EMBL:AAH15651.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:12466895};
CC IsoId=Q8WTU2-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:15489334};
CC IsoId=Q8WTU2-2; Sequence=VSP_052695, VSP_052696;
CC -!- INDUCTION: Not induced by a combination of IL1A/interleukin-1 alpha,
CC IL6/interleukin-6 and dexamethasone. {ECO:0000269|PubMed:12466895}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH15651.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAD18764.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ306913; CAC88128.1; -; Genomic_DNA.
DR EMBL; AJ306914; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306915; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306916; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306917; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306918; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306919; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306920; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306921; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ306922; CAC88128.1; JOINED; Genomic_DNA.
DR EMBL; AJ312755; CAC84764.1; -; mRNA.
DR EMBL; AK172783; BAD18764.1; ALT_FRAME; mRNA.
DR EMBL; AC005522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471220; EAW71806.1; -; Genomic_DNA.
DR EMBL; BC015651; AAH15651.1; ALT_SEQ; mRNA.
DR EMBL; BC113840; AAI13841.1; -; mRNA.
DR CCDS; CCDS5585.1; -. [Q8WTU2-1]
DR RefSeq; NP_542782.1; NM_080744.1. [Q8WTU2-1]
DR AlphaFoldDB; Q8WTU2; -.
DR SMR; Q8WTU2; -.
DR BioGRID; 126464; 50.
DR IntAct; Q8WTU2; 2.
DR MINT; Q8WTU2; -.
DR STRING; 9606.ENSP00000275560; -.
DR GlyGen; Q8WTU2; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; SSC4D; -.
DR DMDM; 74751496; -.
DR MassIVE; Q8WTU2; -.
DR MaxQB; Q8WTU2; -.
DR PaxDb; Q8WTU2; -.
DR PeptideAtlas; Q8WTU2; -.
DR PRIDE; Q8WTU2; -.
DR Antibodypedia; 14947; 96 antibodies from 20 providers.
DR DNASU; 136853; -.
DR Ensembl; ENST00000275560.4; ENSP00000275560.3; ENSG00000146700.9. [Q8WTU2-1]
DR GeneID; 136853; -.
DR KEGG; hsa:136853; -.
DR MANE-Select; ENST00000275560.4; ENSP00000275560.3; NM_080744.2; NP_542782.1.
DR UCSC; uc003ufb.4; human. [Q8WTU2-1]
DR CTD; 136853; -.
DR DisGeNET; 136853; -.
DR GeneCards; SSC4D; -.
DR HGNC; HGNC:14461; SSC4D.
DR HPA; ENSG00000146700; Tissue enhanced (kidney, parathyroid gland, pituitary gland).
DR MIM; 607639; gene.
DR neXtProt; NX_Q8WTU2; -.
DR OpenTargets; ENSG00000146700; -.
DR PharmGKB; PA37883; -.
DR VEuPathDB; HostDB:ENSG00000146700; -.
DR eggNOG; ENOG502QU9F; Eukaryota.
DR GeneTree; ENSGT00940000160521; -.
DR HOGENOM; CLU_002555_11_2_1; -.
DR InParanoid; Q8WTU2; -.
DR OMA; DWAWHTD; -.
DR OrthoDB; 158600at2759; -.
DR PhylomeDB; Q8WTU2; -.
DR TreeFam; TF329295; -.
DR PathwayCommons; Q8WTU2; -.
DR SignaLink; Q8WTU2; -.
DR BioGRID-ORCS; 136853; 15 hits in 1065 CRISPR screens.
DR GenomeRNAi; 136853; -.
DR Pharos; Q8WTU2; Tdark.
DR PRO; PR:Q8WTU2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8WTU2; protein.
DR Bgee; ENSG00000146700; Expressed in parotid gland and 133 other tissues.
DR Genevisible; Q8WTU2; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 3.10.250.10; -; 4.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF00530; SRCR; 4.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 4.
DR SUPFAM; SSF56487; SSF56487; 4.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Reference proteome; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..47
FT /evidence="ECO:0000255"
FT CHAIN 48..575
FT /note="Scavenger receptor cysteine-rich domain-containing
FT group B protein"
FT /evidence="ECO:0000255"
FT /id="PRO_5000067535"
FT DOMAIN 58..158
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 189..289
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 344..444
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 473..573
FT /note="SRCR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 83..147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 96..157
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 127..137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 214..278
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 227..288
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 258..268
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 369..433
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 382..443
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 413..423
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 498..562
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 511..572
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 542..552
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT VAR_SEQ 271..274
FT /note="LGWG -> KTVS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_052695"
FT VAR_SEQ 275..575
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_052696"
FT VARIANT 128
FT /note="R -> H (in dbSNP:rs4728712)"
FT /id="VAR_052063"
FT CONFLICT 520
FT /note="L -> I (in Ref. 2; BAD18764)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 575 AA; 60819 MW; 013BD759EFDB4331 CRC64;
MHKEAEMLIG PQLDEKRWGW RLGDGSAAPP FLPQALSFLL LLPLASALQP TPLPFQELRL
VGGPSRCRGR LEVMHGGSWG SVCDDDWDVV DANVVCRQLG CGLALPVPRP LAFGQGRGPI
LLDNVECRGQ EAALSECGSR GWGVHNCFHY EDVAVLCDEF LPTQPPTRKM LTSRAPPTTL
PNGKSEGSVR LVGGANLCQG RVEILHSGLW GTVCDDDWGL PDAAVVCRQL GCGAAMAATT
NAFFGYGTGH ILLDNVHCEG GEPRLAACQS LGWGVHNCGH HEDAGALCAG LGPPTLTALP
SSATREDWAW QTDPSATGVG PQPSRETALL TTAAWAAGKK SGRLRLVGGP GPCRGRVEVL
HAGGWGTVCD DDWDFADARV ACREAGCGPA LGATGLGHFG YGRGPVLLDN VGCAGTEARL
SDCFHLGWGQ HNCGHHEDAG ALCAGPEELG LQVQQDGSET TRVPTPRPRD GHLRLVNGAH
RCEGRVELYL GQRWGTVCDD AWDLRAAGVL CRQLGCGQAL AAPGEAHFGP GRGPILLDNV
KCRGEESALL LCSHIRWDAH NCDHSEDASV LCQPS
