SRB4D_MOUSE
ID SRB4D_MOUSE Reviewed; 586 AA.
AC A1L0T3;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Scavenger receptor cysteine-rich domain-containing group B protein {ECO:0000250|UniProtKB:Q8WTU2};
DE AltName: Full=Four scavenger receptor cysteine-rich domains-containing protein {ECO:0000250|UniProtKB:Q8WTU2};
DE AltName: Full=S4D-SRCRB {ECO:0000250|UniProtKB:Q8WTU2};
DE Flags: Precursor;
GN Name=Ssc4d {ECO:0000312|MGI:MGI:1924709};
GN Synonyms=Srcrb4d {ECO:0000312|EMBL:AAI26948.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAI17748.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-586.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AC087420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC117747; AAI17748.1; -; mRNA.
DR EMBL; BC126947; AAI26948.1; -; mRNA.
DR CCDS; CCDS51664.1; -.
DR RefSeq; NP_001153838.1; NM_001160366.1.
DR RefSeq; XP_006504400.1; XM_006504337.1.
DR AlphaFoldDB; A1L0T3; -.
DR SMR; A1L0T3; -.
DR STRING; 10090.ENSMUSP00000106782; -.
DR PaxDb; A1L0T3; -.
DR PeptideAtlas; A1L0T3; -.
DR PRIDE; A1L0T3; -.
DR Antibodypedia; 14947; 96 antibodies from 20 providers.
DR DNASU; 109267; -.
DR Ensembl; ENSMUST00000111152; ENSMUSP00000106782; ENSMUSG00000029699.
DR Ensembl; ENSMUST00000111153; ENSMUSP00000106783; ENSMUSG00000029699.
DR GeneID; 109267; -.
DR KEGG; mmu:109267; -.
DR UCSC; uc008zzj.2; mouse.
DR CTD; 136853; -.
DR MGI; MGI:1924709; Ssc4d.
DR VEuPathDB; HostDB:ENSMUSG00000029699; -.
DR eggNOG; ENOG502QU9F; Eukaryota.
DR GeneTree; ENSGT00940000160521; -.
DR HOGENOM; CLU_002555_11_2_1; -.
DR InParanoid; A1L0T3; -.
DR OMA; DWAWHTD; -.
DR OrthoDB; 158600at2759; -.
DR PhylomeDB; A1L0T3; -.
DR TreeFam; TF329295; -.
DR BioGRID-ORCS; 109267; 2 hits in 71 CRISPR screens.
DR PRO; PR:A1L0T3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; A1L0T3; protein.
DR Bgee; ENSMUSG00000029699; Expressed in vestibular epithelium and 112 other tissues.
DR ExpressionAtlas; A1L0T3; baseline and differential.
DR Genevisible; A1L0T3; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR Gene3D; 3.10.250.10; -; 4.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF00530; SRCR; 4.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 4.
DR SUPFAM; SSF56487; SSF56487; 4.
DR PROSITE; PS00420; SRCR_1; 4.
DR PROSITE; PS50287; SRCR_2; 4.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..58
FT /evidence="ECO:0000255"
FT CHAIN 59..586
FT /note="Scavenger receptor cysteine-rich domain-containing
FT group B protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000322582"
FT DOMAIN 69..169
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 200..300
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 355..455
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 484..584
FT /note="SRCR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 94..158
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 107..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 138..148
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 225..289
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 238..299
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 269..279
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 380..444
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 393..454
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 424..434
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 509..573
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 522..583
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 553..563
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 586 AA; 61916 MW; 3C7230F0AE43768A CRC64;
MGPSERPSIG WTPKEAEMQI GPQPDGWSRG WKPGDRGAVP LPLSPALSFL LLFPLASALQ
PTPLPFPELR LVGGPSRCRG RLEVMHSGSW GSVCDDDWDV VDANVVCRQL GCGLALPVPR
PLAFGQGRGP IFLDNVECRG QEASLSECGS RGWGVHNCFH YEDVAVLCDE FLHTQPPTRK
VLTSMAPATA LQNGKGEGSV RLVGGASPCQ GRVEILHGGV WGTVCDDDWG LQDAAVVCRQ
LGCGVALAAT TNAFFGYGTG HILLDNVHCE GGEPRLAACQ SLGWGVHNCG HHEDAGVLCA
VLSPPTSTAL PPSVTKEDWA RHTGPAATGV GASPSRDTVW LTTAARASGK KSGRLRLVGG
PSPCRGRVEV LYAGGWGTVC DDDWDFADAR VACREAGCGP ALGATGLGHF GYGRGPVLLD
NVGCTGTEAR LSDCFHLGWG QHNCGHHEDA GALCAGPEEL GLQVQQAGSE TTRMPSPRPR
DGHLRLASGT HRCEGRVELF LGQRWGTVCD DAWDLRAAIV LCRQLGCGQA LAAPGEAHFG
PGRGPILLDN VKCRGDESTL LLCSHIRWDV HNCDHSEDAS VLCQPL
