SRB6_CAEEL
ID SRB6_CAEEL Reviewed; 337 AA.
AC P54141;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Serpentine receptor class beta-6;
DE Short=Protein srb-6;
GN Name=srb-6; ORFNames=R05H5.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28873053; DOI=10.7554/elife.23770;
RA Tran A., Tang A., O'Loughlin C.T., Balistreri A., Chang E., Coto Villa D.,
RA Li J., Varshney A., Jimenez V., Pyle J., Tsujimoto B., Wellbrook C.,
RA Vargas C., Duong A., Ali N., Matthews S.Y., Levinson S., Woldemariam S.,
RA Khuri S., Bremer M., Eggers D.K., L'Etoile N., Miller Conrad L.C.,
RA VanHoven M.K.;
RT "C. elegans avoids toxin-producing Streptomyces using a seven transmembrane
RT domain chemosensory receptor.";
RL Elife 6:E23770-E23770(2017).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=7585938; DOI=10.1016/0092-8674(95)90162-0;
RA Troemel E.R., Chou J.H., Dwyer N.D., Colbert H.A., Bargmann C.I.;
RT "Divergent seven transmembrane receptors are candidate chemosensory
RT receptors in C. elegans.";
RL Cell 83:207-218(1995).
CC -!- FUNCTION: Mediates recognition and avoidance of Streptomyces species by
CC detecting dodecanoic acid secreted by the bacteria. Also mediates
CC avoidance of decanoic acid which is not secreted by Streptomyces
CC species but this may represent an additional important avoidance
CC response in the environment. {ECO:0000269|PubMed:28873053}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the ADL, ADF and ASH chemosensory
CC neurons in the head and in the PHA and PHB chemosensory neurons in the
CC tail. Low expression also observed in the egg-laying structures in the
CC mid-body region. {ECO:0000269|PubMed:7585938}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defective head
CC and tail avoidance responses to Streptomyces and to dodecanoic acid. It
CC also results in severely reduced calcium influx into ASH neurons in
CC response to both S.avermitilis and dodecanoic acid.
CC {ECO:0000269|PubMed:28873053}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein srb family.
CC {ECO:0000305}.
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DR EMBL; Z48795; CAA88729.1; -; Genomic_DNA.
DR PIR; T23942; T23942.
DR RefSeq; NP_496199.1; NM_063798.1.
DR AlphaFoldDB; P54141; -.
DR STRING; 6239.R05H5.6; -.
DR PaxDb; P54141; -.
DR EnsemblMetazoa; R05H5.6.1; R05H5.6.1; WBGene00005071.
DR GeneID; 191788; -.
DR KEGG; cel:CELE_R05H5.6; -.
DR UCSC; R05H5.6; c. elegans.
DR CTD; 191788; -.
DR WormBase; R05H5.6; CE02293; WBGene00005071; srb-6.
DR eggNOG; ENOG502TFE3; Eukaryota.
DR GeneTree; ENSGT00970000195867; -.
DR HOGENOM; CLU_045882_1_0_1; -.
DR InParanoid; P54141; -.
DR OMA; PSISYFM; -.
DR OrthoDB; 1708683at2759; -.
DR PhylomeDB; P54141; -.
DR PRO; PR:P54141; -.
DR Proteomes; UP000001940; Chromosome II.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IMP:UniProtKB.
DR GO; GO:0009593; P:detection of chemical stimulus; IMP:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:InterPro.
DR InterPro; IPR002184; 7TM_GPCR_serpentine_rcpt_Srb.
DR PANTHER; PTHR31216; PTHR31216; 1.
DR Pfam; PF02175; 7TM_GPCR_Srb; 1.
DR PRINTS; PR00699; TMPROTEINSRB.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Sensory transduction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..337
FT /note="Serpentine receptor class beta-6"
FT /id="PRO_0000104500"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 337 AA; 38966 MW; F1CE611363D6740C CRC64;
MNDCDEVNNI SYDPLYRYSQ FYTLLTSIFS VFPLLYLIIF KLRVCTFNDN IKFLYIVYFT
QILISVLNNC VVFAHHVVIP FLAVSKCDLL VNPVKNRIFQ NIGVFGISCP MLTILGITAE
RLLALIFARC YENVKLHIGV FIGVFAMLCD MALVYFFFLD EKFDQPSISY FMVPDTSGYK
MNWLCYSLLA INSVNLVFNY FLVKINTILK EKWRNSLSTR YQMEENIITT KFSTFISFIH
VFFFSLYLIF TLIIRLLGPG FLKTQADLMS VRGVYITIPT YNLIIGIASC VILRHLQRQK
VAKVYAEVTL KYSGIDGAQI HQEAILNVWK TKSSGRK
