SRB8_ASPCL
ID SRB8_ASPCL Reviewed; 1591 AA.
AC A1CJ92;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE AltName: Full=Mediator complex subunit 12;
GN Name=srb8; Synonyms=med12; ORFNames=ACLA_034190;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the srb8-11 complex. The srb8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The srb8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the srb8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
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DR EMBL; DS027056; EAW09216.1; -; Genomic_DNA.
DR RefSeq; XP_001270642.1; XM_001270641.1.
DR AlphaFoldDB; A1CJ92; -.
DR STRING; 5057.CADACLAP00003921; -.
DR EnsemblFungi; EAW09216; EAW09216; ACLA_034190.
DR GeneID; 4702894; -.
DR KEGG; act:ACLA_034190; -.
DR VEuPathDB; FungiDB:ACLA_034190; -.
DR eggNOG; KOG4522; Eukaryota.
DR HOGENOM; CLU_002034_1_0_1; -.
DR OMA; DNKREAW; -.
DR OrthoDB; 285540at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019035; Mediator_Med12.
DR Pfam; PF09497; Med12; 1.
DR SMART; SM01281; Med12; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1591
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12"
FT /id="PRO_0000312965"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1591 AA; 175528 MW; D1C9C3F803A29680 CRC64;
MIPHSSAGVQ PWGHPLRAVH SASGLTDIPH ALGQPDLHPE QSSMPAPQPQ TGPSAVIDLT
ANGGEAQERE HPAKRLRLDI HSGSNARDGS PASAGLGEPK STPVSTSSKP PPLSWRGRPV
WSFQALLSEV PGAGEPNVES TTAAAQDVKP LSPPSFPAPP WKHSPADPTA SSAAGLRGVT
PAKEVRTTPY HIEVPSVAPV LRGDKVADFL PWTGNHPEDV LNEQTAKQGY YDRTQVSQNE
SNTARPSLYA QLKHRSGLQM LSSVFAAALE KRQGHSMVTA PSTFKPPPRV TLTDNKREAW
LRDLANPTVP LRRLSRTIPH GIRGRVLLDQ CLTKWVPVGR AVWLAKCVGA NEIRAFKRKG
TSGALAIGLE AKWVRDWTTN VQQFLDGVIT SCGVADWKLK MTYAVSLTAR LFFEQLLDHD
QYLGWFLSSL EAAPLNTLPV WLLMLGIYWN HLLRYRKRGR RLAELLLEKL SKANKLDSSN
TLRPLADRLS LHIRKLTLEH TSSAVLPHSW DKYKDLLSSC LNMKDSVHRA VIQNLSERNA
RVQRPRKCQE TANQPPQQRV IQLFDSIRST HDVTAVSIAS LSAIDDKAAL VFKLLEWVST
PFRHGICRVY TGARLLRKWK VAGVDVDSCI ISFLAEGHDG SHLNMDNIYH IISELVRSQT
FSVGRYLQWL MAKGVADCSK DSHQHHKHLS DDLELLLQLP VSRLPDHVRN LRNTLLHRAG
IEVSKEEAMI ATLKASIAQR LPNIFSSVTD SAMSCDVAQS ELTWAVKSEI GQWIRRGVTE
GRRGSTGKFQ IAIGQPVLSA DEFYSIRDIL EGFGDLSMLA DVLNQATNCD DGLILASAAD
TVNYHFQSFS VIGASTGLFR RFVESYARLK RLGVTSLDLI LSLIDLGLHL PGEFNTVALL
RQDLGRIENK SSMAAPSPLS DHIPATFNET DSLFPEKLDQ LLFSGGGMDE STMDAIFNAL
ITSLGRAEDR VKLSANDICR YLAYLRPFHP KHFDIMLIRW ICGLLKSSTR TMLSRVLPPL
IGVGCVTIQA FIFLVRRLLQ SEKVASMIPH PNDLKIDLLQ LLVPPPAGQS RYFDMVTYRF
HLSQKEFLSK HPEETFNIIR DAIALIDSQD QDNHSDQGQM NLNQNAMVLL QILLTKNPES
AVQYCTEKLI TQHSTSMMVL TKALDTLLGF DTGPDPPNVS VAEKVIELTN DFSLPFCQLK
LQTLFNAEAG SNVKNEIVDV MFKAAIADSR SRRSNWVGLV RLMNQDAVRQ IRERAEKSFF
AIPLFEEANE GRSMNNGTSL ETAKLYLTII EKLAYSIPDS GVQGVGSVLV EKMDLLLHKL
VSMQTSYNGS TEMRHGIDAE QVIQSRTEFE RSLAFWFSAL LRMIVLHRSA FSIPPAPKSS
ASQEQTRLLI SIFCITLARL PDSVLRLFPT ADYFPHSMRQ GDHRPCPGIL LQTHALDVAA
SLIDMFPDEL RHQCARFLKD KCSPFAQSQN DSRFLYLLGP LGDGPTSNAT LPVSIPSPAA
SGSTPAPTPS GSLTAGPSNP PQPASASLGV PTGLPEGLNC GASHLCLQYR GRAIGAYPVR
PWELLEDAAP IAGTNDTAVS LGYFDARRVR A
