SRB8_ASPFU
ID SRB8_ASPFU Reviewed; 1617 AA.
AC Q4WWL0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE AltName: Full=Mediator complex subunit 12;
GN Name=srb8; Synonyms=med12; ORFNames=AFUA_3G06250;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the srb8-11 complex. The srb8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The srb8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the srb8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
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DR EMBL; AAHF01000002; EAL92943.2; -; Genomic_DNA.
DR RefSeq; XP_754981.2; XM_749888.2.
DR AlphaFoldDB; Q4WWL0; -.
DR STRING; 746128.CADAFUBP00004200; -.
DR PRIDE; Q4WWL0; -.
DR EnsemblFungi; EAL92943; EAL92943; AFUA_3G06250.
DR GeneID; 3511712; -.
DR KEGG; afm:AFUA_3G06250; -.
DR eggNOG; KOG4522; Eukaryota.
DR HOGENOM; CLU_002034_1_0_1; -.
DR InParanoid; Q4WWL0; -.
DR OMA; DNKREAW; -.
DR OrthoDB; 285540at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019035; Mediator_Med12.
DR Pfam; PF09497; Med12; 1.
DR SMART; SM01281; Med12; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1617
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12"
FT /id="PRO_0000312966"
FT REGION 25..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1519..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1617 AA; 178101 MW; 7DA059760C942848 CRC64;
MIPHSSAGVQ SWGQPLYAVY TGTGRADLSQ PLGQPDRQSE QPSMPVAQTQ GRPPALIDLT
ANDGDVLERE PPAKRLKIDV HAGSVANDGS PASAGVGESK STPGATTSKP PSLSWRARPV
WSFQSLLSEI PGSAEINGES AAGVVQDLKP PPPPSFSGPP WKFAPTDIIA SDSAGEQDGA
SAKEVQTTPY HIETPSVAPV IRGEKVADFS PWMGNHPEDV LNEQTAKQGY YDRTQVSQNE
SNTARPSLYA QLKHRSGLQI LSSVFAAALE KRQGHNMVTA PSTFKPPPRV TLTDNKREAW
LRDLANPNVP LRKLSRTIPH GIRGRVLLDQ CLTKWVPVGR AVWLAKCVGA NEIRAFKRKG
TSGALTIGLE AKWVRDWTAN VQQFLEGVIT SCGVADWKMK VTYAVNLTSR LFFEQLLDHD
QYLEWFLTSL EAAPFNTLPV WLLMLGIYWS NILRYRKRGR RLAELLLDKL QLAIKSDSAP
SLRPLIDRLS LHIRKLTLEH TSSMVLPQSW EKYKDLLSSC LNLNDNVHRT VFQILAERNA
RVQKPPKCEG TTQQPPQQRV IQLFDSICSS HDITSVSAAS LRAIDDKAAL VLKLLEWAAT
PFRYGVSRVY TGARLLRKWK IAGVDVDTCI ISFLGESQMS DQLNMDNVYH IVSELVRSQT
FSVGKYLQWL MAKGVADFSR SSDHQPLSGD LALLVQLPVS RLPEHVHNLR NTLLHRAGVE
PSKEASTIAI LKASIAERLP RIFGSVATSA VSCDPLPSDL TWTVKSELGQ WIRRGVTEFG
RDPRRAFQGL HSTTSAEHFA LTPGEFYTVR DILESFGDLS ILADVLKQAT VCNDGIVLAS
AADTVNYHFR SFCVIGATTD LFKRLVEAYA RLKRLGSTSL DLIFSLIDLG LRLPGELNTV
ALLRQDLSRI ESKSSMAAPS PLSDHIPSSF NENDPLFLLK LDQLLSSASG IDESTLDTIF
NVLIKQLESS GGHAKFSVNE ICRYLSYLRP FHPKRFDTMI VRWVCGLLRS STGGILSQVL
PPLIGVGCVT IQAFVFLVRR LLKSDNKISN QRDLRIDLLQ LLVPPPAGQS RYFDLVTYRF
HLSRKEFLFK HPEEAFDIIR DAIALIDSES QEGNYRQVDL GHSAMVLLQI LLTKNPESAV
RHCSEKLIGQ HPSAVTVLTR ALDSLLGLDS KAGGHLFTSN DTFIFIPIDT GPATPDISVA
EKVIELTNDF SLPFCQLKLQ LLFNAESKGN VRNEIVDVMF KAAVADSRSR RSNWVGLVSL
MSHDAVRQVK CHDIRERAEK NFFATPLFEE SPDGCSSFAA DNSSSLEAAK LYLAIIEKLA
YSIPDVGPQA VVPVLTEKLD LLLQRLISMQ ASCSGTTELS HGVDAEQMIR SRTQFERALA
FWFSALLRMI VLHRTAFSVP SAAVRPNALP EQTRLLISIF CISLARLPDS VLRLFPAADY
FPHSMRAADC RPCPGILLQT HALDVAASLI DMFPDEARHQ CARYLREKCP PFARVQNDSR
FLYLLGPLGD SPSSNITLPV SIPSPAASGS TPAPTPSGNS TGGFSHPQQP AFVSGVPPGL
PDGLNCAASH LCLQYRGRVI GAYPVRPWEL LEDAAPIAGT NDTAVSLGYF DARRVRV
