ID   SRB8_ASPTN              Reviewed;        1583 AA.
AC   Q0CBX9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE   AltName: Full=Mediator complex subunit 12;
GN   Name=srb8; Synonyms=med12; ORFNames=ATEG_08805;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the srb8-11 complex. The srb8-11 complex is a
CC       regulatory module of the Mediator complex which is itself involved in
CC       regulation of basal and activated RNA polymerase II-dependent
CC       transcription. The srb8-11 complex may be involved in the
CC       transcriptional repression of a subset of genes regulated by Mediator.
CC       It may inhibit the association of the Mediator complex with RNA
CC       polymerase II to form the holoenzyme complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the srb8-11 complex, which itself associates with
CC       the Mediator complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU30937.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH476606; EAU30937.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001217391.1; XM_001217390.1.
DR   AlphaFoldDB; Q0CBX9; -.
DR   STRING; 341663.Q0CBX9; -.
DR   GeneID; 4323238; -.
DR   eggNOG; KOG4522; Eukaryota.
DR   OrthoDB; 285540at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR019035; Mediator_Med12.
DR   Pfam; PF09497; Med12; 1.
DR   SMART; SM01281; Med12; 1.
PE   3: Inferred from homology;
KW   Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1583
FT                   /note="Mediator of RNA polymerase II transcription subunit
FT                   12"
FT                   /id="PRO_0000312968"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1481..1525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..114
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1494..1525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1583 AA;  174417 MW;  5DB3E955614B84D9 CRC64;
     MIPHSSAGVQ QWGHHPLHAL NPGAGRTDTA SALGPSDLQL EKAPMSAPQP QLRQPAVVDL
     TTHSGDTSER EPPSKRLRLD LPSVASTGDA SPASGNGEPR NTPSTSTPTA KPSSLSWRGR
     PVWSFQALIS EIPGSGGMSE EDAAAVAQSG KPASPPPFPV LPWKYAPPEA AGNKSVKSRD
     SSPAKKVQTT PYHIECPSVA PVLKGQKVAD FSPWTGNHPE DVLNEQTAKQ GHYDRTQVSQ
     NESNTARPSL YAQLKHRSGL QMLSSVFAAA LEKRQSHNLV NAPSTFKPPP RVTLTDNKRE
     AWLRDLANPS VPLRRLSRTI PHGIRGKALL DQCLSKWIPV NRAVWLAKCV GANEIRAFKR
     KGTSGAVVIG LEAKWVREWT AHVQQFLEGL VAACGTADWK MKMTYAVGLT ARLFFERLLD
     DEQYLGWFLS SLEAASLNTV PVWLLMLGIY WDSIMRYRKR GRRLAEALLE KLRQVTNPEH
     ATTLRPLVDR LSLHIRTLVV EHTSSVILPN SWAKYKDLVL SCLNMKDNTH KAIFQNVAER
     NARIQLSKDR QDSGQRSPQQ RVIHLFDAVC STHDVASAAA ACLKTIDDKS LLVTKLLEWT
     ATPFRCGLCR VYTAVRLLRK WKMSGVDIDT YILSFLTRTG NRASLTMDNI YHVISELVRS
     QTFSVGRYLQ WLMAKGVSSS NQSDHSIDLY LLKQLPMTRL PDHVRNLRNT LLYRAGVPAT
     LEDSTIAELK ASIAGRLPNI FGNEVEHTMV VESPSLDLTW AVKSEIGQWL RRGISGHCRN
     ATSAMAGITV PADRNVSRLT PDEFYHIRDV LESFGDLSML ADVVKQTTSC DDNIVLASAA
     DTVNYHFDSF CVIGATSDLF RSLVESYARL KRLGTPNLDL VFSLIELGLR LPQECNTVAL
     LRQDLLRIES KSALAAPSPL SDNPSTAINE ADPSFRSKLD QLLSSGGGMD ESTMASIFAS
     LTNILTGRNE DVKLSANETC RYLAYLRPFH PKHFDAMLVR WVCGLLKSSA RSTMPHILPP
     LIGVGCVTIH AFVFLVKKLL QSERIASKIP NPARLKMDIL DLLVPPAPGQ SRYFDLVTYR
     FHLAQQEFLL KYYKETLDII CDALSTNAAA AGINSELRSS ATTLLRLLLA QEPEDVVQYC
     LQKISAQHST FTSVLQDTLD QLLQSVSLHD PQVSMAENVI RTTDDFSLPF CQLKLQVLSN
     AESKENMGDG IVDVMFKAAV ADTRAKGSNW IGLVRLMSPN SVQQIRERAE KEFFAVPLFA
     ETLGDQSLSY APNTEALETA KLYLTIIDKL AYSIPEAGVQ SVGPILVEKM DLLLHKLVVM
     QTSLVTRQGV VSDQATQSRA NFERALAFWF SALLRMIVIH RTAFNVPSSV PRATVVQDQS
     RLLVSIFCIS LARLPTNILR LYPTADYFPH PISSEGYRPC PGILLQTHAL DVAASLIDTF
     PDESRQQCAR FLKDKCPPFL QFQNDNRFSY LLGPVPDAGT SNIPPPASVP SPAAAAASTP
     TPTPSSGLPP GSSTQQASST LSGIPTGVSE DCVASRLRLQ YRGRTIGPYP VRPWELLEDA
     APIVGVNDTA VNLKFFDARR VRA