SRB8_CANGA
ID SRB8_CANGA Reviewed; 1358 AA.
AC Q6FVM9;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE AltName: Full=Mediator complex subunit 12;
GN Name=SRB8; Synonyms=MED12; OrderedLocusNames=CAGL0E00627g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
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DR EMBL; CR380951; CAG58634.1; -; Genomic_DNA.
DR RefSeq; XP_445715.1; XM_445715.1.
DR AlphaFoldDB; Q6FVM9; -.
DR SMR; Q6FVM9; -.
DR STRING; 5478.XP_445715.1; -.
DR PRIDE; Q6FVM9; -.
DR EnsemblFungi; CAG58634; CAG58634; CAGL0E00627g.
DR GeneID; 2887477; -.
DR KEGG; cgr:CAGL0E00627g; -.
DR CGD; CAL0129076; SRB8.
DR VEuPathDB; FungiDB:CAGL0E00627g; -.
DR eggNOG; KOG4522; Eukaryota.
DR HOGENOM; CLU_256280_0_0_1; -.
DR InParanoid; Q6FVM9; -.
DR OMA; EFIVYHQ; -.
DR Proteomes; UP000002428; Chromosome E.
DR GO; GO:1990508; C:CKM complex; IEA:EnsemblFungi.
DR GO; GO:0016592; C:mediator complex; IEA:EnsemblFungi.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblFungi.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0000411; P:positive regulation of transcription by galactose; IEA:EnsemblFungi.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0006468; P:protein phosphorylation; IEA:EnsemblFungi.
DR InterPro; IPR019035; Mediator_Med12.
DR Pfam; PF09497; Med12; 1.
DR SMART; SM01281; Med12; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1358
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12"
FT /id="PRO_0000312969"
SQ SEQUENCE 1358 AA; 158953 MW; 134E226348B2BCA4 CRC64;
MIPSKYKLAP PDDLHPYSES ERAKHKIYPD FDPWKHTKEE DEILLNFVSK GYYSTSKVNF
ESISARSSLQ DSLPKLSSTL SEKFSEVVRI REREINTIKG NSKDGMAASK FTDLCGPDFK
LPSRLTLTDH RKELWLQELS SPYTPLHKIT SFIPHGLKRR QVLEQCYIKQ IPLKRAVWLI
KCCYSIEWKT GIAKYANSPQ EKDKFNAHLL KEWTDNFVHI LEKLIFEMTQ HYNDSVKLEA
WKTEVSYFLK LVGNCYTLEL IDKNTFHFWI LQFVSKVENF EYLPLPLHIL ELFWSGICNT
NSTKVNESES NPLYMVTKLT DILLNQYYII LHSKSMINDD KYIINDIKKN NSIKESLLAS
IQKLICILFK QQSLEVFLFP PTSWEKYKPC LIQITSALYR KSDEVAEIKR KLELISYRNE
TLKYTPPISE NKVKDDLILT TFTENSGSIT VVELSQVDTG LTGALDDNAT DFDWTSYSDQ
EISTKIQIIQ IILWAIHPSR HSHYEAGQLA AKLLLLKINT MDGFPEYEIE DEIWSLVFKL
AKLSDKSKAL PAVLEALYSL LNTLIVYGLI KVSTYIRKLI SSGILYLTES NDKYIHCRLL
INLKMSPLMK SQYNMVLKNV MDQDPEYYNN YNFDQIVSIV EDLKVKLPNG DAIEYSNYPM
SVKISLGEWY LTYLCNGKLV NETRESLTEK YVLFAHQLNT NHLYFKWIEF IVYHQLIEDI
ETLEYLMEVL LRYKKLFSQY INDHVLFIKT FIFIIRRILK ERDSIAYSLT SFMDFWKFIM
KSYSLEIRAD TDLRSEMSAV YEEEKAKKEI TEGEKDSWMG LYQNIHPDST SLDQNHTGFS
ELFLTNLKTF LSSKQDKQAK KKARYNLLLL MQAKNRDYSK FISIYLKRKD FKTSDLVNLL
SSKLLTLDQI KNTYGLKYVL ELFDIESESN CVFYEYQKRC YIELNYKSVL SEYNVVSHHE
MNRFIFKIVN HSTSAKLKET ASALLTKNLE ANKDKAIQLF YQLVYYQNNL EFLSSEELQE
FAVNNSPQKL YSYLDFTNLW LFQSFTKFYI HETFQNTNED KVKVGDVIFS IIETTKYNVL
CAKIFEDIRD HRVTDLVIEL FEQDFFKKII SGEEFKAEFL QMLIEIINHL SMHKGKTNDR
SGEQSHTSYE LCVQVMAHFQ QLSDSELSAK EIELDVFMKI FTVHQNSVFQ EILRDTESSS
AMIESLFALF ERVNFSLRLK LMFYEVLSSL KSYCTYEAGI SDEQSRTKLM HKLMCLPPFQ
VSSFFPEEDD TDCTRDPALS LGLDLGTASA NSTSSTTPSE GTHKKRCAIW DKRLHKYTGE
LQRKPYYCIK NYQDTEDINN CSLNLSLFDA RYERNNPR
