SRB8_DEBHA
ID SRB8_DEBHA Reviewed; 1661 AA.
AC Q6BUQ1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE AltName: Full=Mediator complex subunit 12;
GN Name=SRB8; Synonyms=MED12; OrderedLocusNames=DEHA2C08998g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
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DR EMBL; CR382135; CAG86139.2; -; Genomic_DNA.
DR RefSeq; XP_458068.2; XM_458068.1.
DR AlphaFoldDB; Q6BUQ1; -.
DR STRING; 4959.XP_458068.2; -.
DR EnsemblFungi; CAG86139; CAG86139; DEHA2C08998g.
DR GeneID; 2900807; -.
DR KEGG; dha:DEHA2C08998g; -.
DR VEuPathDB; FungiDB:DEHA2C08998g; -.
DR eggNOG; KOG4522; Eukaryota.
DR HOGENOM; CLU_003142_0_0_1; -.
DR InParanoid; Q6BUQ1; -.
DR OMA; EKFEIHW; -.
DR OrthoDB; 285540at2759; -.
DR Proteomes; UP000000599; Chromosome C.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019035; Mediator_Med12.
DR Pfam; PF09497; Med12; 1.
DR SMART; SM01281; Med12; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1661
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12"
FT /id="PRO_0000312971"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1661 AA; 191934 MW; 848D5C8C653D54E0 CRC64;
MSKTKNRNSL LSSHNRTSVS NSTKDELLAM KYVMDKPAIP LYPLNELSNS SESISEQNRY
TSNSSTDELT YPDFKPWKDT THLPKGKSEV EVEKLNNEAY LNKGYFEGPS VANEYYSARN
LIQASLFSSS SNCDKVLKEL SQHLVNSYRT RNEVINKIKY NSNKFKIPPR VTLTASKKEA
WLRDLANPDE PLSNISNKLP HGIKNKMLVD ILCSKNIPTS RALWLTKCVL YSELLVLKKK
YQSRLPNNPH PVENTTSETF ETQWLQEWTH QLVDYFYKFS KDMCNITIQE KKQVYLTKLN
YLLNYVQALY IECLLDKSFF LTSILKFLKE GLPLDQSHVS ELLAFSRSEG EESSLDKWLV
DIDLNYGQRL ISITLVKMFW KDILELDYLS KELSELLLLN YYFIERIPTY NTKSSNYSHK
QNHTAALSST LKLKLLSSIS DTVNYLFKHN TNVFIIPNYW ILVNETLYKI LLSDVANSYD
SEEQTEIRKQ LKLIKYRNES LMLSMKDVQS SNFVDVNTAR NLAKDRRRSN SLQQSLSQDT
KNNYNSITGK KIPNTVENDN YFINRNSDDT LNIIDQLDRL KLNDTLAEML IPSSISSSPD
NFNDWRVNLK VVIYWAITIY REQMSSSEGI LIICNFLKRK VLQNISVKNV NSIKAEFENE
ILEIIYNLAH CTDVDIIDYN LYVLINELYQ LKVITISSYL RKLIASGLFY VSPSADGAQS
HNENNSSVET HLAILQNLPV LNNKQCDSIL RKWTPNGFNF EEKFEKGKLI LKEELVDRLM
SNSFDGYCDE KLTYIKNLKV GLKFLLVNWL TNYLKTSITK SPKLIHINPN IITSLYNFYA
LCDNLTVFFK VLIKFILRNE GKVIICYMDS LYLISKLIIR HFKLVKFIAG KSYESTTTGY
ELFKLIILNY KDLSTRDNDY YNFSDVWYFI DNAVEKNEPT YGKSSDGNND NALKHKNFNQ
LLFAKETVDS PMRIHANSNT PQKNNDSYTA TVFRNDLDLL LEAPIKLLNN TDITDFISTL
ELNVSNEAFN EISNTEESVI IIMEYYFKNI GEFTELHENL CMRLLINSKR SLDMTTRGIF
FDIMKHFIIN LVRTKPGIEK LITLFKKLMC FEVYQPHELF STLRSILPRE LSHEQMDALK
YELLFGNPES DNKNLFNDQA LVLRCIRYLY VKRHSNDVFI TLLDSFSNEK ETFFNSYALK
AYNSKVLSFF RQFSISNTKF FMDGLSKVAS NSDIISFLNL LIYISEEPIG SSSDLPRLAS
IIDEFNLPVC QVLIKIIIMN ELRDSNKDKS IEKLRYILDM LLNNLKFHFV SYNSYFGELF
NYLSWEHKLN ILSIFEHNFL CNTEFIVSDD KFTENSVCLM SSDGRTNLLS ILKDYFKKFS
VSSLNTVTTS KEVFHNLSKF LLKVLQLANA DIIGDSRRDA YNTISIFLRI LIIHKLSLTS
MIIEQDGQDL HFIKNLIALL ESKFLCFNNE KLRILLYDLL LLMKSSITSS MILNPDSNLA
DDMTTDTSHQ QHSPSNDYLS RSNPDGTEVG NSNSKYFGVS NISTIPNLSS VFNISEPNIS
YPLKKYTDDS KILCALMLEE SELQKGGDIY ALNDSKLILL PSRREALSSA FDILNETQQT
VSKKRFKIES YELLEDTGIE LNNGCINLSL FDAFTTKENP P
