SRB8_EMENI
ID SRB8_EMENI Reviewed; 1582 AA.
AC Q5B3Y9; C8VAT3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE AltName: Full=Mediator complex subunit 12;
GN Name=srb8; Synonyms=med12; ORFNames=AN4741;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Component of the srb8-11 complex. The srb8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The srb8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the srb8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF76885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA60783.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACD01000080; EAA60783.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001303; CBF76885.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_662345.1; XM_657253.1.
DR AlphaFoldDB; Q5B3Y9; -.
DR STRING; 162425.CADANIAP00005687; -.
DR EnsemblFungi; EAA60783; EAA60783; AN4741.2.
DR GeneID; 2872539; -.
DR KEGG; ani:AN4741.2; -.
DR eggNOG; KOG4522; Eukaryota.
DR HOGENOM; CLU_002034_1_0_1; -.
DR InParanoid; Q5B3Y9; -.
DR OrthoDB; 285540at2759; -.
DR Proteomes; UP000000560; Chromosome III.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019035; Mediator_Med12.
DR Pfam; PF09497; Med12; 1.
DR SMART; SM01281; Med12; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1582
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12"
FT /id="PRO_0000312972"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..163
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1582 AA; 174506 MW; 21F265BB8B844842 CRC64;
MIPNSSAGGQ SWGHPLRNVD NDTARGDTSQ AFNRPDIRSE GQQYTPALPR HPGQPAVIDL
TSSANDAQEG QPPAKRLKLD ITAESSANPA SPTPATTGDS RVTPGIANSK PSALSWRGRP
VWSFQAMISE VMSGAEATEE DAILAPQGKR PASPPPFPQP SWKGAPPEQF GSNATKASES
DSSKKVQTTP FRVEVPSIAP ALKGDKVADF APWIGNHPED ILSEQTVKQG HYDRTQVSQN
ESNTARPSLY AQLKHRSGLQ MLSSVFMAAL EKRQNHNTIN VPSNFKPPPR VTLTDNKREA
WLRDLANPSV PLRRLSRTIP HGIRGKNLLD QCLSKWIPVN RAVWLVKCVG ANEIRACKRK
GTGGTLVVGS EVKWVRDWTS GVQQFLEGVI GACGSADWKS KMTYATSLTA RLFFERLLDH
DQYFAWFLTS LEGASLNMVP VWLLMLGIYW DSMLRYRKRG RRLAEVLLGK LHQTTELQRP
TLLQPLAERL SCCIRKLVLE HTSSLILPNS WETHRDLILS CLNMKETADK TIFDSLAERN
SRIQLPSSRS DSTRQSAHQR VIQLFDSIQS SQDIASTSVA CLNALEDRQT LVIKLLEWSA
TSFRSGLHRV YTAARLLRKW KISGVDIDTY IISFLSTVQD LAQLDMDNVY HIISELVRSQ
TFSVSRYLQW LMAKGVARKS SGTSGEVLAA DARLLTQLPM SRSPEHVRNL RLTLLARAGV
SVDEESSTIK CLKSSISQRL PNIFEVEASN SKHINFSKHD LTWAVKSEVS MWIRQGVVKH
LKDTTRISAL TPGEFYCVRE ILERFGDCSI LADVLKQAIE CDDNIILASV SDTVNYHFDA
LSMIGATSDL FRGLVGSYAR LKRSGNLSLD FVFSLIELGL RLPDESGTVY LLRQDLARIE
SKSALAAPSP LSDHIPTTFN EVDASFQERL EQLLSCGNGL DESTMGAIIS SLTKILTDGG
GAAKVSAKDA CRYLAYLRPF NPKYLDGMLV RYVYGLLKSS SRPTMSQVLS PLIGVGCVTI
HSFVLLVNKL SASAQTTGAI ANPDSLRLDI LELLLPQEES SADMVTYRFR LAQQEFLVKY
PEETLNIISD AIPLFDADFH DANLGSRRPD LPACTVVLLR TLLAQNSSLV LKYCMQKLDG
HSSFTTVLGK AVDILLGLDP EDEMEPSSQA ERVILMNNDF SLPYCQLKLK LLFNAKAGNE
VKNHIVDVMF KAAVTDSRSK RSHWVGLVSL MDQEAARQIR ERAEGCFFSV AMFDESMDDT
SLPSGASSLS SIESAKLYLN IIEKLAYSIP QAGVQSIPPL LVERLDLLLQ KLIIMQINSN
SVAASSSGST IVSKINFERA LAFWFSALLR LIVLHRAAFN VPPASGSKVD SLREQTRLLV
SILCISLARL PENILRLFPA ADYFPHTIQS HNFRPCPGIL LQTHALDVAA SLIDSFPDEA
RHQCVRFLRE RCPPFLKFQN DRRFLYLLGP MTDTTIPSSQ LSASISSPAA GGSTPTPIPS
GTLSGGHSSQ ATQQMAALTG PFSGLSENTK LVADRLRIQN GGRINGPYPV RPWELLEDAA
PILGVNDTAV SLKLFDARRV RA
