SRB8_PHANO
ID SRB8_PHANO Reviewed; 1547 AA.
AC Q0V6H6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 12;
DE AltName: Full=Mediator complex subunit 12;
GN Name=SRB8; Synonyms=MED12; ORFNames=SNOG_00388;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 12 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAT91883.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH445325; EAT91883.2; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001791074.1; XM_001791022.1.
DR AlphaFoldDB; Q0V6H6; -.
DR STRING; 13684.SNOT_00388; -.
DR PRIDE; Q0V6H6; -.
DR GeneID; 5968362; -.
DR KEGG; pno:SNOG_00388; -.
DR eggNOG; KOG4522; Eukaryota.
DR InParanoid; Q0V6H6; -.
DR OMA; DNKREAW; -.
DR OrthoDB; 285540at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR019035; Mediator_Med12.
DR Pfam; PF09497; Med12; 1.
DR SMART; SM01281; Med12; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Activator; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1547
FT /note="Mediator of RNA polymerase II transcription subunit
FT 12"
FT /id="PRO_0000312976"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1357..1371
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1372..1481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1547 AA; 170654 MW; 52CE14F698D8D96E CRC64;
MTSRPALGTH GSGAPSRNQV RRPSKPANAL PPDCIDPTLE DERPAAHNGA SEARPPPRGR
PHIFYSTLAS SAFDLPIHSF PYQPTVNLPV PPRPGSLHLR DASQQRQILP GGTGVKDAPK
LGVPETVPIP VHFPGEKAAD VFPWTGTNAE DTLSEALVKA GVSNKPQIMN ETNTARPSLW
SNLKNKSGIT TLSTLFVAVL EKRQQNGRLQ TPNTFKPPPR LTLRDSTREG WLHDLANPTV
SLRRLSRTIP HGLTGKVLLD QCLNKNIPLP RALWLAKCVG INELRAHKRK GQAGTVTWGR
GWTSSVEQFL DSVISTIGQG DWKLRITYAL QLATHLYKEH LLDDDHFLGW IPFGLDMCSS
ERLFIWLLVV AVPHYWNDIS SCRQRGKRLA ESLLNHLAKL SPIEDLAAPS TALQFLENSL
LKLVTTRPAC LLLPISWPKH SAALKALVTK RNLPQTAQAV EKLDGRNTRL LSFVRNGKSS
SRTGAARVFH KLDSINYAAP IRIEDLSYEC MEITSNAVQL ISTLLHWACS CYRAGSHRIY
LATRLLRRWS HLGADVYEGI IVYLQSMSWV KSGEIHVLLR IVAELVRSKH FSVGRYLQWL
IATGSLGCDA SLSLPSSWPV RLITEVPLTG LSDQVRTLRS TLLRGTAHST ELEEQALVNV
KQSISQAVPA IFGLSLTIPS RIELNFAKLS GTIRLEIGIW LRQQVAQHAE VNEQSYLEQC
EDLAILADVI GITASSLDMA VLASVADTLL YHMKTFRAIG AFDPLLGRLA MRYAAIRTVK
FPERELLLSF QNLARTAQPD GQLLQLLAYD LSRLDQKNAV AACSPASDNM GEVMQHAGTC
SDDEIERILS SGTSMDQNMM SRVLRKLVRN LEEHVDKGYR QFENHPAWFW RLRNFDEATF
DVVLREWLET SIMACQLHIL QIAIPPLVAS SCMELSSFLD ILRSCLANAK ATQVLEPATI
AIDLLRLLLP SGLSAMSCSS QDAYRYRTEQ YKLCFTSDTR IIHCIGEVAD LVLSTPSNSM
LQTVSSLLSS ETVLSIVKEH VVSDPDCLSK MKTGQSGQAS FNTCFKTLLN GLLDPSGQWC
LADISPEEQI IAVFKAASEL SLPLCQAMIE HIFASSSALD THAVDRLSVT VLNAVRTSME
KDQSQGLELL TNLEGPLADK IRSHAEREVL DASYFLLRGS TDGIASDCIV TAKMMQKYLT
VIELTMGETP QADEQFAMLA ALTDRFKGIF HALSECGGLG TPTNQATASP VVQVLAALLS
LVASHGPQLL RNATQSHQAA LMVALQDIVT HASLELFPSI IEHVFDVLIV LSDHISEDVR
NQIARLESAK STNSDRAYFI HSQKAPIDGW LMLTKPVIPP LEPPQPPNPN TTQNQSSPYQ
SPQMTSNTAA PQHRYFNQQQ QQSQTLQPSQ QTQHMRTYPQ YAQHAAQPNR HLPAQLQRTP
SHHASLSPLQ QMQHMQQLQG LAQQRASQPS PIHSQRPTSV ASPGGMGGLA GGNAAPSKAH
TSYVNQQRDT QQYPFVQPRW EILAESSGNP TLNETAISLS LFGARRV
