SRBD1_MOUSE
ID SRBD1_MOUSE Reviewed; 982 AA.
AC Q497V5;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2018, sequence version 3.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=S1 RNA-binding domain-containing protein 1;
GN Name=Srbd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Oocyte;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q497V5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q497V5-2; Sequence=VSP_024462, VSP_024464;
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DR EMBL; AC154185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100359; AAI00360.1; -; mRNA.
DR AlphaFoldDB; Q497V5; -.
DR SMR; Q497V5; -.
DR STRING; 10090.ENSMUSP00000092810; -.
DR iPTMnet; Q497V5; -.
DR PhosphoSitePlus; Q497V5; -.
DR EPD; Q497V5; -.
DR jPOST; Q497V5; -.
DR MaxQB; Q497V5; -.
DR PaxDb; Q497V5; -.
DR PeptideAtlas; Q497V5; -.
DR PRIDE; Q497V5; -.
DR ProteomicsDB; 261653; -. [Q497V5-1]
DR ProteomicsDB; 261654; -. [Q497V5-2]
DR MGI; MGI:1925836; Srbd1.
DR eggNOG; KOG1857; Eukaryota.
DR InParanoid; Q497V5; -.
DR PhylomeDB; Q497V5; -.
DR ChiTaRS; Srbd1; mouse.
DR PRO; PR:Q497V5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q497V5; protein.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd05685; S1_Tex; 1.
DR Gene3D; 1.10.10.650; -; 1.
DR Gene3D; 1.10.3500.10; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.420.140; -; 1.
DR InterPro; IPR041692; HHH_9.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044146; S1_Tex.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR018974; Tex-like_N.
DR InterPro; IPR032639; Tex_YqgF.
DR InterPro; IPR006641; YqgF/RNaseH-like_dom.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR Pfam; PF17674; HHH_9; 1.
DR Pfam; PF00575; S1; 1.
DR Pfam; PF09371; Tex_N; 1.
DR Pfam; PF16921; Tex_YqgF; 1.
DR SMART; SM00316; S1; 1.
DR SMART; SM00732; YqgFc; 1.
DR SUPFAM; SSF47781; SSF47781; 2.
DR SUPFAM; SSF50249; SSF50249; 1.
DR SUPFAM; SSF53098; SSF53098; 1.
DR PROSITE; PS50126; S1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Phosphoprotein;
KW Reference proteome; RNA-binding; Ubl conjugation.
FT CHAIN 1..982
FT /note="S1 RNA-binding domain-containing protein 1"
FT /id="PRO_0000284358"
FT DOMAIN 906..979
FT /note="S1 motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT REGION 1..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 256..283
FT /evidence="ECO:0000255"
FT COMPBIAS 30..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..67
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 951
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5C6"
FT CROSSLNK 84
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N5C6"
FT CROSSLNK 130
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N5C6"
FT CROSSLNK 161
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N5C6"
FT CROSSLNK 162
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N5C6"
FT CROSSLNK 942
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q8N5C6"
FT VAR_SEQ 1..370
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024462"
FT VAR_SEQ 773
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_024464"
SQ SEQUENCE 982 AA; 110281 MW; 917DF85563A61B3B CRC64;
MPSLRKRVKI QAENAEPKDE CSFFSELSSG SEEDNKEDSI WEPQKKVPRN RRQPASKGSK
RKQGPRAKKS SQQVDDESKD VAVKEELNSP VAIVDADLEE KSHKLQTTKT LKTAAKKQKK
PVPRAKKRLK VDEETSQASP LEGGGSNVET PSTSACGNVC KKEESEDSFT FGQSPVKRIR
TESCPQGRPA RVPDGVSDIK EEVEMNWDVV QVLSERTNIE PWVCANIIRL FNDDNTIPFI
VRYRKELINN LDADFLREVR QTLDELRDVA KKVHSRIQKI KKEGKMSECL LQALLNCKTF
EELEHVSAPY KMGSKGTKAQ RAKQLGLEGA AWTLLENPGQ LNLLSYIKPD VKGLSELNDI
ETGVQHILAD MIAKDKDTLD FIRGLCKHRY ICIQSSLAKV SSKKVNEKEV DKFQLYQNFS
CNIRTIHHHQ ILAINRGENL KILTVKVNIS DGVKNEFCRW CIQNRWRPRG FARPELMKIL
HNSLDDSFKR LIVPLLCREF RAKLTSDAEK QSVMMFGQNL RQLLLTSPVP GRTLMGVDPG
YKHGCKLAII SPTSQILHTD VVYLHCGQGF REAEKIKRLL LHFNCRTVVI GNGTACRETE
AYFADLIMKN YFAPLDVVYC IVSEAGASIY SVSPEANKEM PGLDPNLRSA VSIARRVQDP
LAELVKFDPK HIGVGMYQHD VSQTLLKATL DSVVEECVSF VGVDINICSE VLLRHIAGLN
ANRAKNIIEW REKNGPFINR EQLKKVKGLG PKSFQQCAGF VRINQDYIRT FCSSQHTDSS
GQSQETAMVT NEKLGKKKNK ADATLIPNPL DQTCIHPESY DIAVRFLSFI GGTMCEIGKP
EMQQKINVSL GKEGIEETAE RLQTTVHTLQ VIIDGLSQPK TFDIRTDFDK PDFKRSIVCL
EDLQVGTVLT GKVENATLFG VFVDIGVGKA GLIPIRFITE AKLSKTKRRR SLGLGPGEKV
EVKVLNVDIP RSRISLDLLR VL
