SRBP1_CUCSA
ID SRBP1_CUCSA Reviewed; 160 AA.
AC A0A0A0LLY1;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 07-JAN-2015, sequence version 1.
DT 03-AUG-2022, entry version 27.
DE RecName: Full=Small RNA binding protein 1 {ECO:0000303|PubMed:31812689};
DE Short=CsSRBP1 {ECO:0000303|PubMed:31812689};
GN Name=SRBP1 {ECO:0000303|PubMed:31812689};
GN ORFNames=Csa_2G247040 {ECO:0000312|EMBL:KGN61792.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR
RP LOCATION, DOMAIN, SUBUNIT, AND GENE FAMILY.
RC STRAIN=cv. 9930 Chinese long;
RX PubMed=31812689; DOI=10.1016/j.molp.2019.12.001;
RA Yan Y., Ham B.-K., Chong Y.H., Yeh S.-D., Lucas W.J.;
RT "A plant SMALL RNA-BINDING PROTEIN 1 family mediates cell-to-cell
RT trafficking of RNAi signals.";
RL Mol. Plant 13:321-335(2020).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930;
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan X., Wu Z., Zhang J., Cai Q., Bai Y., Zhao B., Han Y.,
RA Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- FUNCTION: Possibly has a role in RNA transcription or processing during
CC stress (By similarity). Binds sequence non-specifically to RNAs and
CC DNAs (By similarity). Mediates cell-to-cell trafficking of RNA
CC interference (RNAi) signals (small RNAs (sRNA), e.g. small interfering
CC RNA (siRNA) and microRNA (miRNA)) which regulate growth and
CC development, as well as responses to environmental inputs, including
CC pathogen attack; can compromise zucchini yellow mosaic virus (ZYMV) and
CC tobacco rattle virus (TRV) infections at the early stage
CC (PubMed:31812689). {ECO:0000250|UniProtKB:Q9LIS2,
CC ECO:0000269|PubMed:31812689}.
CC -!- SUBUNIT: Binds to small phloem-mobile single-stranded RNAs (ss-sRNA,
CC e.g. small interfering RNA (siRNA) and microRNA (miRNA)) in the phloeme
CC exudate, including viral-derived sRNA (vsiRNA).
CC {ECO:0000269|PubMed:31812689}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31812689}.
CC Note=Observed in the phloem translocation stream.
CC {ECO:0000269|PubMed:31812689}.
CC -!- TISSUE SPECIFICITY: Accumulates in phloem exudates.
CC {ECO:0000269|PubMed:31812689}.
CC -!- DOMAIN: The glycine-rich (GR) domain is necessary and sufficient for
CC cell-to-cell movement and to interefere with zucchini yellow mosaic
CC virus (ZYMV) infection. {ECO:0000269|PubMed:31812689}.
CC -!- SIMILARITY: Belongs to the GR-RBP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MN064662; QGZ19397.1; -; mRNA.
DR EMBL; CM002923; KGN61792.1; -; Genomic_DNA.
DR STRING; 3659.XP_004148845.1; -.
DR EnsemblPlants; KGN61792; KGN61792; Csa_2G247040.
DR Gramene; KGN61792; KGN61792; Csa_2G247040.
DR eggNOG; KOG0118; Eukaryota.
DR OMA; GVPNMYQ; -.
DR Proteomes; UP000029981; Chromosome 2.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0035198; F:miRNA binding; IDA:UniProtKB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB.
DR GO; GO:0035197; F:siRNA binding; IDA:UniProtKB.
DR GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0006858; P:extracellular transport; IDA:UniProtKB.
DR GO; GO:1990428; P:miRNA transport; IDA:UniProtKB.
DR GO; GO:0050688; P:regulation of defense response to virus; IDA:UniProtKB.
DR GO; GO:0050658; P:RNA transport; IDA:UniProtKB.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Plant defense; Reference proteome; RNA-binding; Secreted.
FT CHAIN 1..160
FT /note="Small RNA binding protein 1"
FT /id="PRO_0000454536"
FT DOMAIN 8..86
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 82..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..157
FT /note="Glycine-rich (GR) required for cell-to-cell
FT movement"
FT /evidence="ECO:0000305|PubMed:31812689"
SQ SEQUENCE 160 AA; 15973 MW; 083487C029ABA5E0 CRC64;
MASSSVEFRC FVGGLAWATD SNSLEKAFSV YGEIVEAKIV SDRETGRSRG FGFVTFLEEE
AMRSAIEAMN GHILDGRNIT VNEAQQRGGG GGGGYNRGGG YGGRRDGGGF SRGGGGGYGG
GGGGGYGGGR DRGYGGGGGY GGGRDSRGSG GGGSEGGWRN
