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SRCA_CHICK
ID   SRCA_CHICK              Reviewed;         472 AA.
AC   Q90577; A0A1D5P984; A0A1D5PLW0;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Sarcalumenin {ECO:0000250|UniProtKB:P13666};
DE   Flags: Precursor;
GN   Name=SRL;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Anterior latissimus dorsi muscle;
RA   Boyd K.L., Kutchai H., Takeyasu K.;
RT   "Molecular cloning of the 53kDa glycoprotein from chicken sarcoplasmic
RT   reticulum.";
RL   Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
CC   -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen
CC       {ECO:0000250|UniProtKB:P13666}. Sarcoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:P13666}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P13666}. Note=May associate with the
CC       sarcoplasmic reticulum membrane, via a calcium-dependent mechanism.
CC       {ECO:0000250|UniProtKB:P13666}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=53 kDa {ECO:0000303|Ref.1};
CC         IsoId=Q90577-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q90577-2; Sequence=VSP_060760, VSP_060761;
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:P13666}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01055}.
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DR   EMBL; Z21720; CAA79817.1; -; mRNA.
DR   EMBL; AADN05000376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S45068; S45068.
DR   RefSeq; NP_990660.1; NM_205329.1.
DR   AlphaFoldDB; Q90577; -.
DR   SMR; Q90577; -.
DR   STRING; 9031.ENSGALP00000038763; -.
DR   Ensembl; ENSGALT00000061825; ENSGALP00000049285; ENSGALG00000038884. [Q90577-1]
DR   Ensembl; ENSGALT00000074172; ENSGALP00000053831; ENSGALG00000038884. [Q90577-2]
DR   GeneID; 396269; -.
DR   KEGG; gga:396269; -.
DR   CTD; 6345; -.
DR   VEuPathDB; HostDB:geneid_396269; -.
DR   eggNOG; KOG1954; Eukaryota.
DR   GeneTree; ENSGT00940000157834; -.
DR   InParanoid; Q90577; -.
DR   OMA; GIIPENR; -.
DR   OrthoDB; 377342at2759; -.
DR   PhylomeDB; Q90577; -.
DR   PRO; PR:Q90577; -.
DR   Proteomes; UP000000539; Chromosome 14.
DR   Bgee; ENSGALG00000038884; Expressed in skeletal muscle tissue and 6 other tissues.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR031692; EHD_N.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF16880; EHD_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW   Sarcoplasmic reticulum; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..472
FT                   /note="Sarcalumenin"
FT                   /id="PRO_0000045428"
FT   DOMAIN          89..330
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          99..106
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          127..128
FT                   /note="G2 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          189..192
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          254..257
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   REGION          278
FT                   /note="G5 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01055"
FT   CARBOHYD        280
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        388
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         20
FT                   /note="A -> ADEDVGRAAQRPSSEALPHVEEMAANGSPEEEEEDGGAANTSVLRTA
FT                   EGGGEREEELKGGLSEAAGQGQEGPDGASGKDAMLGGPGAEGEAAPEPGTQHGGQEEEE
FT                   ANTKEVASEEKEMEEPRVSAPEGGEEEDEQSSEEDDEQEESEEDEGKAESEEEGKSAEE
FT                   GESEEDGASPEVLEDGAEGTDMKETPGENSHGKAAASSEGEQRDGPASCHHPPCGDVEP
FT                   SPGSSSQAAAEEPSTAVEEAAATEDPPTAVKIPPAALENPPTAEDPPAAVGDPPADQAP
FT                   LAEMENPASPSARHAAAEPRRSQI (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060760"
FT   VAR_SEQ         84
FT                   /note="I -> ITAYPGRTLGSSA (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_060761"
FT   CONFLICT        127
FT                   /note="E -> G (in Ref. 1; CAA79817)"
FT   CONFLICT        162
FT                   /note="E -> K (in Ref. 1; CAA79817)"
FT   CONFLICT        177
FT                   /note="V -> L (in Ref. 1; CAA79817)"
FT   CONFLICT        270
FT                   /note="Missing (in Ref. 1; CAA79817)"
FT   CONFLICT        396
FT                   /note="N -> Q (in Ref. 1; CAA79817)"
FT   CARBOHYD        Q90577-2:59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   472 AA;  54264 MW;  1A8F45D8D49DA7D6 CRC64;
     MKRLNLLCCC VASLLLLGTA EEVEDASEPT KRDRSHLENT LKLNEDKPAD DFSGVLQRLR
     KIYHASIKPL EQSYRYNELR QHEITDGEIT SKPMVLFLGP WSVGKSSMIN YLLGLDDTPY
     QLYTGAEPTT SEFTVIMHGP KLKTIEGIVM AADSARSFSP LEKFGQNFLE KLIGIEVPHK
     LLERVTFVDT PGIIENRKQQ ERGYPFNDVC QWFIDRADLI FVVFDPTKLD VGLELEMLFR
     QLKGRESQIR IILNKADSLA TQELMRVYGA LFWSLAPLIN VTEPPRVYVS SFWPHEYHPD
     THKDLFLKEE ISLLEDLNQV IENRMENKIA FIRQHAIRVR IHALLVDRYL QTYKDKMTFF
     SDGELVFRDI VEDPDKFFIF KSILAKTNVS KFDLPNREAY KDFFGINPIT SFKLLSQQCS
     YMGGCYLEKI EKAITRELPD LLGSIGLGKK PNVLSCDVTG CGETPKNRYK KP
 
 
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