SRCH_RABIT
ID SRCH_RABIT Reviewed; 852 AA.
AC P16230;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Sarcoplasmic reticulum histidine-rich calcium-binding protein;
DE Flags: Precursor;
GN Name=HRC; Synonyms=HCP;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND PYROGLUTAMATE
RP FORMATION AT GLN-28.
RC TISSUE=Skeletal muscle;
RX PubMed=2808365; DOI=10.1016/s0021-9258(19)84681-1;
RA Hofmann S.L., Goldstein J.L., Orth K., Moomaw C.R., Slaughter C.A.,
RA Brown M.S.;
RT "Molecular cloning of a histidine-rich Ca2+-binding protein of sarcoplasmic
RT reticulum that contains highly conserved repeated elements.";
RL J. Biol. Chem. 264:18083-18090(1989).
CC -!- FUNCTION: May play a role in the regulation of calcium sequestration or
CC release in the SR of skeletal and cardiac muscle.
CC -!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen.
CC -!- PTM: The N-terminus is blocked. {ECO:0000269|PubMed:2808365}.
CC -!- SIMILARITY: Belongs to the HRC family. {ECO:0000305}.
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DR EMBL; J05080; AAA31279.1; -; mRNA.
DR PIR; A34373; A34373.
DR RefSeq; NP_001075703.1; NM_001082234.1.
DR AlphaFoldDB; P16230; -.
DR MINT; P16230; -.
DR PRIDE; P16230; -.
DR GeneID; 100009049; -.
DR KEGG; ocu:100009049; -.
DR CTD; 3270; -.
DR InParanoid; P16230; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0033018; C:sarcoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR InterPro; IPR002134; His-rich_Ca-bd_rpt.
DR InterPro; IPR019552; Hist_rich_Ca-bd.
DR InterPro; IPR015666; HRC.
DR PANTHER; PTHR15054; PTHR15054; 3.
DR Pfam; PF10529; Hist_rich_Ca-bd; 11.
DR PROSITE; PS00328; HCP; 10.
PE 1: Evidence at protein level;
KW Calcium; Direct protein sequencing; Phosphoprotein;
KW Pyrrolidone carboxylic acid; Reference proteome; Repeat;
KW Sarcoplasmic reticulum; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..852
FT /note="Sarcoplasmic reticulum histidine-rich calcium-
FT binding protein"
FT /id="PRO_0000022415"
FT REPEAT 59..79
FT /note="1-1"
FT REPEAT 80..100
FT /note="1-2"
FT REPEAT 199..224
FT /note="2-1"
FT REPEAT 225..253
FT /note="2-2"
FT REPEAT 254..282
FT /note="2-3"
FT REPEAT 283..310
FT /note="2-4"
FT REPEAT 311..339
FT /note="2-5"
FT REPEAT 340..367
FT /note="2-6"
FT REPEAT 368..395
FT /note="2-7"
FT REPEAT 396..423
FT /note="2-8"
FT REPEAT 424..451
FT /note="2-9"
FT REPEAT 452..470
FT /note="2-10"
FT REGION 44..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..100
FT /note="2 X approximate tandem repeats"
FT REGION 199..470
FT /note="10 X tandem repeats, acidic"
FT REGION 471..585
FT /note="4 X approximate tandem repeats"
FT REGION 780..826
FT /note="Metal-binding"
FT /evidence="ECO:0000255"
FT COMPBIAS 63..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..319
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..376
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..486
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..575
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..645
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 28
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000305|PubMed:2808365"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23327"
FT MOD_RES 518
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23327"
FT MOD_RES 544
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23327"
FT MOD_RES 614
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P23327"
SQ SEQUENCE 852 AA; 96117 MW; A43C0CB3E494B930 CRC64;
MGCRGPWLHT CLLWAAVASL LLPPAVTQQL RGAGLGPSTW INNAGAPGPS GEAAAAGLGH
HGHSHRSPGE ENEDVSMENG HHFWSHRDHG ETDDEVSREY GHQPQGHRYH SPEAGDESVS
EEGVHREQAR QAPGHGGHGE AGAEDLAEHG SHGHGHEEED EDVISSERPR HVLRRAPRGH
GGEEEGEEEE EEEEVSPEHR HRGHGKEDEE DEDDDSTESD RHQAHRHRGH REEEDEDDDD
DEGDSTESDH HQAHRHRGHE EEEDEEDDDD EGDSTESDRH QAHRHRGHRE EEDEDDDDEG
DSTESDRHQA HRHRGHREEE DDDDDDDEGD STESDRHQAH RHRGHREEED EDDDDEGDST
ESDRHQAHRH RGHREEEDED DDDEGDSTES DRHQAHRHRG HREEEDEDDD DEGDSTESDH
HQAHRHRGHR EEEDEEDDDE GDSTESDRHQ AHRHRGHGEE EDEDDDDEGE HHHVPHRGHR
GHEEDDGGDD DDGDDSTENG HQAHRHQGHG KEEAEVTSDE HHHHVPDHGH QGHGDKEGEE
EGVSTDHWHQ VPRHAHHGPG GEEEGGEEEL TVKAGHHVAS HPPPGHRSRE GHAEEHQTEV
PGHHQHRMGD TDTSAERGHP ASSPRQQGHP PEDTVHHHRG SLKEEVGPES PGPAGVKDGS
RVKRGGSEEE EEQKGTHHHS LEDEEDEEEG HGRSLSQEDQ EEEDRRGESA KVQAPLRHHR
EEEEEEEEEE EEEGRLPFTI IPNPLSGREA AGGASSEESA EDTGPEDTQE YGNYQQGSLC
GYCTFCNRCT ECEHCHCDED SMGEHCDQCQ HCQFCYLCPL VCETVCTPGS YVDYFSSSLY
KALADMLETP EP
