位置:首页 > 蛋白库 > SRCR1_PATPE
SRCR1_PATPE
ID   SRCR1_PATPE             Reviewed;        1128 AA.
AC   F7J220;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Scavenger receptor cysteine-rich domain superfamily protein {ECO:0000312|EMBL:BAK39578.1};
DE            Short=ApSRCR1;
DE   Flags: Precursor;
GN   Name=SRCR1 {ECO:0000312|EMBL:BAK39578.1};
OS   Patiria pectinifera (Starfish) (Asterina pectinifera).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Valvatacea; Valvatida; Asterinidae; Patiria.
OX   NCBI_TaxID=7594;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAK39578.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=21703301; DOI=10.1016/j.dci.2011.06.005;
RA   Furukawa R., Matsumoto M., Kaneko H.;
RT   "Characterization of a scavenger receptor cysteine-rich-domain-containing
RT   protein of the starfish, Asterina pectinifera: ApSRCR1 acts as an opsonin
RT   in the larval and adult innate immune systems.";
RL   Dev. Comp. Immunol. 36:51-61(2012).
CC   -!- FUNCTION: Involved in aggregate formation and phagocytosis by larval
CC       mesenchyme cells and adult coelomocytes. Binds to bacteria and may act
CC       as an opsonin in the innate immune system.
CC       {ECO:0000269|PubMed:21703301}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000269|PubMed:21703301}; Single-pass type I membrane protein
CC       {ECO:0000269|PubMed:21703301}.
CC   -!- TISSUE SPECIFICITY: From the mid-gastrula stage, expressed only in
CC       mesenchyme cells that are migrating toward the body wall. At the
CC       brachiolaria stage, expressed in presumptive coelomocytes of the
CC       coelomic pouch. Also expressed in adult coelomocytes (at protein
CC       level). {ECO:0000269|PubMed:21703301}.
CC   -!- DEVELOPMENTAL STAGE: During larval development, expression is first
CC       detected in the mid-gastrula stage and increases thereafter (at protein
CC       level). {ECO:0000269|PubMed:21703301}.
CC   -!- INDUCTION: By bacterial challenge in adult coelomocytes.
CC       {ECO:0000269|PubMed:21703301}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB621549; BAK39578.1; -; mRNA.
DR   AlphaFoldDB; F7J220; -.
DR   SMR; F7J220; -.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 1.
DR   Gene3D; 3.10.250.10; -; 9.
DR   InterPro; IPR001190; SRCR.
DR   InterPro; IPR017448; SRCR-like_dom.
DR   InterPro; IPR036772; SRCR-like_dom_sf.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00530; SRCR; 9.
DR   Pfam; PF00084; Sushi; 1.
DR   PRINTS; PR00258; SPERACTRCPTR.
DR   SMART; SM00032; CCP; 1.
DR   SMART; SM00202; SR; 9.
DR   SUPFAM; SSF56487; SSF56487; 9.
DR   SUPFAM; SSF57535; SSF57535; 1.
DR   PROSITE; PS00420; SRCR_1; 5.
DR   PROSITE; PS50287; SRCR_2; 9.
DR   PROSITE; PS50923; SUSHI; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Immunity;
KW   Innate immunity; Membrane; Phagocytosis; Repeat; Signal; Sushi;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..1128
FT                   /note="Scavenger receptor cysteine-rich domain superfamily
FT                   protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000415604"
FT   TOPO_DOM        25..1051
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1052..1072
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        1073..1128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          40..140
FT                   /note="SRCR 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          143..245
FT                   /note="SRCR 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          248..348
FT                   /note="SRCR 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          351..450
FT                   /note="SRCR 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          453..553
FT                   /note="SRCR 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          555..654
FT                   /note="SRCR 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          657..757
FT                   /note="SRCR 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          759..866
FT                   /note="SRCR 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          868..968
FT                   /note="SRCR 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT   DOMAIN          969..1028
FT                   /note="Sushi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        190
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        194
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        229
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        422
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        601
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        612
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        765
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        808
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        834
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        936
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        985
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1031
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        65..129
FT                   /evidence="ECO:0000255"
FT   DISULFID        78..139
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..119
FT                   /evidence="ECO:0000255"
FT   DISULFID        168..234
FT                   /evidence="ECO:0000255"
FT   DISULFID        181..244
FT                   /evidence="ECO:0000255"
FT   DISULFID        212..222
FT                   /evidence="ECO:0000255"
FT   DISULFID        273..337
FT                   /evidence="ECO:0000255"
FT   DISULFID        286..347
FT                   /evidence="ECO:0000255"
FT   DISULFID        316..326
FT                   /evidence="ECO:0000255"
FT   DISULFID        376..439
FT                   /evidence="ECO:0000255"
FT   DISULFID        389..449
FT                   /evidence="ECO:0000255"
FT   DISULFID        419..429
FT                   /evidence="ECO:0000255"
FT   DISULFID        478..542
FT                   /evidence="ECO:0000255"
FT   DISULFID        491..552
FT                   /evidence="ECO:0000255"
FT   DISULFID        522..532
FT                   /evidence="ECO:0000255"
FT   DISULFID        583..644
FT                   /evidence="ECO:0000255"
FT   DISULFID        596..653
FT                   /evidence="ECO:0000255"
FT   DISULFID        624..634
FT                   /evidence="ECO:0000255"
FT   DISULFID        682..746
FT                   /evidence="ECO:0000255"
FT   DISULFID        695..756
FT                   /evidence="ECO:0000255"
FT   DISULFID        726..736
FT                   /evidence="ECO:0000255"
FT   DISULFID        803..865
FT                   /evidence="ECO:0000255"
FT   DISULFID        833..843
FT                   /evidence="ECO:0000255"
FT   DISULFID        906..967
FT                   /evidence="ECO:0000255"
FT   DISULFID        937..947
FT                   /evidence="ECO:0000255"
FT   DISULFID        971..1013
FT                   /evidence="ECO:0000255"
FT   DISULFID        999..1026
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1128 AA;  119966 MW;  DCAA7C79A022C736 CRC64;
     MTSLRRGNIC WVAVCAALLT LTRGIDVIAK PSRTPSNGDV QLVGGASPAE GRVEVFYNGA
     WGTVCDDGWE MQDAQIVCKQ LGFASANSTR CCASFGQGTG VIILDDLACT GDETRIGDCP
     HRGWEQHNCA HTEDAGVVCN GKVRLAGSPN PLQGRLEIFH EGEWGTVCDS DWDLKDASVV
     CRQLGYPSAN SSSNVSFGPA STAQILLDRV SCMGDEHGVE YCEHGDWKNV SADCTHSRDA
     GVICTRPIRL VGGNGPMQGR VEILHNGEWG SVCDKGWSFQ NAVVVCNQLG ATQPRRPQGV
     PVGGGVGPTH MSFVNCDGTE ATLEQCSNSG WGNAGECGHS NDAGVICTPA VRLVGGNTHI
     EGRVEVFNNG QWGSICPESW DAKDAEVACR QLGNYPLAEG DCCPQFPADV GVVLDNVVCT
     GNESRIQDCA HQDWGVVDCS GGQAAGAKCQ ATVQLVGGSH PLEGNVIVLR NGRWGSICDD
     NWDINDARVV CRQLGNYEAV AATCCAKYGQ VPQEIILDDV ACQGEEGRIE DCYHATWGSH
     NCGGSESAGV VCREIRLALD DSSSNLPKGR VEIVYNGVWG RICGTDWDLN DANVLCRQLY
     NSTAESVHSF KNGSGPILLS NFKCTGSESN IFDCTHNPWG DYTCDDADAA VVCRGGLRLA
     GGRTPLEGRV EVFHDGQWGT VCDDGWDLLD AKVVCTQLGN YEALSAKCCA NFGQGTGPIL
     IDGLACNGNE DLIEDCRHEG WGSHNCQHYE DAGVVCTDLR LTHENGSVST NTLTGRVEVL
     SSSGEWGAIC GKYWDKKDAE VVCQQLFNTS AMDTRKFYLS SPDQLINMGE VQCNGSESLL
     LQCPRASKPF TAQTCPGGET AGVLCKDIRL VSGNQREFGA VELLVDSQWG SICADNWGPN
     EGAVACKQLG YCAAKGTQKG LQPARTQGKM HFSSMNCTGS ESRLRDCVHT YGGYTCNGLV
     FEAVVQCKAG CDWPGPIRHG SFSPNRSSYD PLTTIDVKCD AGYELMGSKT LQCVTGCDWS
     RPTPECQRIS NCSIGGGGKP SVGAQAGPAG GVMLIIGIIL GAVVMMLIAC VALYLKGRNK
     NIGRGNPATT SAIWKPKKEF DELKEPVLSF SAMTAGGAGP EDGMGEDI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024