SRCR1_PATPE
ID SRCR1_PATPE Reviewed; 1128 AA.
AC F7J220;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 25-MAY-2022, entry version 25.
DE RecName: Full=Scavenger receptor cysteine-rich domain superfamily protein {ECO:0000312|EMBL:BAK39578.1};
DE Short=ApSRCR1;
DE Flags: Precursor;
GN Name=SRCR1 {ECO:0000312|EMBL:BAK39578.1};
OS Patiria pectinifera (Starfish) (Asterina pectinifera).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC Valvatacea; Valvatida; Asterinidae; Patiria.
OX NCBI_TaxID=7594;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAK39578.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=21703301; DOI=10.1016/j.dci.2011.06.005;
RA Furukawa R., Matsumoto M., Kaneko H.;
RT "Characterization of a scavenger receptor cysteine-rich-domain-containing
RT protein of the starfish, Asterina pectinifera: ApSRCR1 acts as an opsonin
RT in the larval and adult innate immune systems.";
RL Dev. Comp. Immunol. 36:51-61(2012).
CC -!- FUNCTION: Involved in aggregate formation and phagocytosis by larval
CC mesenchyme cells and adult coelomocytes. Binds to bacteria and may act
CC as an opsonin in the innate immune system.
CC {ECO:0000269|PubMed:21703301}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000269|PubMed:21703301}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:21703301}.
CC -!- TISSUE SPECIFICITY: From the mid-gastrula stage, expressed only in
CC mesenchyme cells that are migrating toward the body wall. At the
CC brachiolaria stage, expressed in presumptive coelomocytes of the
CC coelomic pouch. Also expressed in adult coelomocytes (at protein
CC level). {ECO:0000269|PubMed:21703301}.
CC -!- DEVELOPMENTAL STAGE: During larval development, expression is first
CC detected in the mid-gastrula stage and increases thereafter (at protein
CC level). {ECO:0000269|PubMed:21703301}.
CC -!- INDUCTION: By bacterial challenge in adult coelomocytes.
CC {ECO:0000269|PubMed:21703301}.
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DR EMBL; AB621549; BAK39578.1; -; mRNA.
DR AlphaFoldDB; F7J220; -.
DR SMR; F7J220; -.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 1.
DR Gene3D; 3.10.250.10; -; 9.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR Pfam; PF00530; SRCR; 9.
DR Pfam; PF00084; Sushi; 1.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00032; CCP; 1.
DR SMART; SM00202; SR; 9.
DR SUPFAM; SSF56487; SSF56487; 9.
DR SUPFAM; SSF57535; SSF57535; 1.
DR PROSITE; PS00420; SRCR_1; 5.
DR PROSITE; PS50287; SRCR_2; 9.
DR PROSITE; PS50923; SUSHI; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Immunity;
KW Innate immunity; Membrane; Phagocytosis; Repeat; Signal; Sushi;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1128
FT /note="Scavenger receptor cysteine-rich domain superfamily
FT protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000415604"
FT TOPO_DOM 25..1051
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1052..1072
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1073..1128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 40..140
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 143..245
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 248..348
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 351..450
FT /note="SRCR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 453..553
FT /note="SRCR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 555..654
FT /note="SRCR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 657..757
FT /note="SRCR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 759..866
FT /note="SRCR 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 868..968
FT /note="SRCR 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 969..1028
FT /note="Sushi"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00302"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 229
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 601
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 612
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 765
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 808
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 834
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 936
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 985
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1031
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 65..129
FT /evidence="ECO:0000255"
FT DISULFID 78..139
FT /evidence="ECO:0000255"
FT DISULFID 109..119
FT /evidence="ECO:0000255"
FT DISULFID 168..234
FT /evidence="ECO:0000255"
FT DISULFID 181..244
FT /evidence="ECO:0000255"
FT DISULFID 212..222
FT /evidence="ECO:0000255"
FT DISULFID 273..337
FT /evidence="ECO:0000255"
FT DISULFID 286..347
FT /evidence="ECO:0000255"
FT DISULFID 316..326
FT /evidence="ECO:0000255"
FT DISULFID 376..439
FT /evidence="ECO:0000255"
FT DISULFID 389..449
FT /evidence="ECO:0000255"
FT DISULFID 419..429
FT /evidence="ECO:0000255"
FT DISULFID 478..542
FT /evidence="ECO:0000255"
FT DISULFID 491..552
FT /evidence="ECO:0000255"
FT DISULFID 522..532
FT /evidence="ECO:0000255"
FT DISULFID 583..644
FT /evidence="ECO:0000255"
FT DISULFID 596..653
FT /evidence="ECO:0000255"
FT DISULFID 624..634
FT /evidence="ECO:0000255"
FT DISULFID 682..746
FT /evidence="ECO:0000255"
FT DISULFID 695..756
FT /evidence="ECO:0000255"
FT DISULFID 726..736
FT /evidence="ECO:0000255"
FT DISULFID 803..865
FT /evidence="ECO:0000255"
FT DISULFID 833..843
FT /evidence="ECO:0000255"
FT DISULFID 906..967
FT /evidence="ECO:0000255"
FT DISULFID 937..947
FT /evidence="ECO:0000255"
FT DISULFID 971..1013
FT /evidence="ECO:0000255"
FT DISULFID 999..1026
FT /evidence="ECO:0000255"
SQ SEQUENCE 1128 AA; 119966 MW; DCAA7C79A022C736 CRC64;
MTSLRRGNIC WVAVCAALLT LTRGIDVIAK PSRTPSNGDV QLVGGASPAE GRVEVFYNGA
WGTVCDDGWE MQDAQIVCKQ LGFASANSTR CCASFGQGTG VIILDDLACT GDETRIGDCP
HRGWEQHNCA HTEDAGVVCN GKVRLAGSPN PLQGRLEIFH EGEWGTVCDS DWDLKDASVV
CRQLGYPSAN SSSNVSFGPA STAQILLDRV SCMGDEHGVE YCEHGDWKNV SADCTHSRDA
GVICTRPIRL VGGNGPMQGR VEILHNGEWG SVCDKGWSFQ NAVVVCNQLG ATQPRRPQGV
PVGGGVGPTH MSFVNCDGTE ATLEQCSNSG WGNAGECGHS NDAGVICTPA VRLVGGNTHI
EGRVEVFNNG QWGSICPESW DAKDAEVACR QLGNYPLAEG DCCPQFPADV GVVLDNVVCT
GNESRIQDCA HQDWGVVDCS GGQAAGAKCQ ATVQLVGGSH PLEGNVIVLR NGRWGSICDD
NWDINDARVV CRQLGNYEAV AATCCAKYGQ VPQEIILDDV ACQGEEGRIE DCYHATWGSH
NCGGSESAGV VCREIRLALD DSSSNLPKGR VEIVYNGVWG RICGTDWDLN DANVLCRQLY
NSTAESVHSF KNGSGPILLS NFKCTGSESN IFDCTHNPWG DYTCDDADAA VVCRGGLRLA
GGRTPLEGRV EVFHDGQWGT VCDDGWDLLD AKVVCTQLGN YEALSAKCCA NFGQGTGPIL
IDGLACNGNE DLIEDCRHEG WGSHNCQHYE DAGVVCTDLR LTHENGSVST NTLTGRVEVL
SSSGEWGAIC GKYWDKKDAE VVCQQLFNTS AMDTRKFYLS SPDQLINMGE VQCNGSESLL
LQCPRASKPF TAQTCPGGET AGVLCKDIRL VSGNQREFGA VELLVDSQWG SICADNWGPN
EGAVACKQLG YCAAKGTQKG LQPARTQGKM HFSSMNCTGS ESRLRDCVHT YGGYTCNGLV
FEAVVQCKAG CDWPGPIRHG SFSPNRSSYD PLTTIDVKCD AGYELMGSKT LQCVTGCDWS
RPTPECQRIS NCSIGGGGKP SVGAQAGPAG GVMLIIGIIL GAVVMMLIAC VALYLKGRNK
NIGRGNPATT SAIWKPKKEF DELKEPVLSF SAMTAGGAGP EDGMGEDI