SRCRM_HUMAN
ID SRCRM_HUMAN Reviewed; 1027 AA.
AC Q4G0T1; C9K0L3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Scavenger receptor cysteine-rich domain-containing protein SCART1 {ECO:0000305};
DE AltName: Full=Scavenger receptor family member expressed on T cells 1 {ECO:0000312|HGNC:HGNC:32411};
DE Flags: Precursor;
GN Name=SCART1 {ECO:0000312|HGNC:HGNC:32411};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), FUNCTION, TISSUE SPECIFICITY,
RP AND ALTERNATIVE SPLICING.
RC TISSUE=Lymphocyte;
RX PubMed=22795646; DOI=10.1016/j.imbio.2012.05.025;
RA Holm D., Fink D.R., Steffensen M.A., Schlosser A., Nielsen O.,
RA Moeller J.B., Holmskov U.;
RT "Characterization of a novel human scavenger receptor cysteine-rich
RT molecule SCART1 expressed by lymphocytes.";
RL Immunobiology 218:408-417(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in the immune system, perhaps as a co-
CC receptor on alphabeta and gammadelta T-cells.
CC {ECO:0000305|PubMed:22795646}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q4G0T1-1; Sequence=Displayed;
CC Name=Gamma;
CC IsoId=Q4G0T1-2; Sequence=VSP_039839, VSP_039840;
CC Name=Alpha;
CC IsoId=Q4G0T1-3; Sequence=VSP_053841, VSP_053842;
CC -!- TISSUE SPECIFICITY: Mainly expressed by CD4(+) and CD8(+) T
CC lymphocytes. Also highly expressed in small intestine and colon.
CC Expressed (at protein level) in small intestine, stomach, gall bladder,
CC and placental villi. {ECO:0000269|PubMed:22795646}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL161645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038300; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; Q4G0T1; -.
DR SMR; Q4G0T1; -.
DR GlyGen; Q4G0T1; 4 sites.
DR BioMuta; -; -.
DR DMDM; 308153504; -.
DR MassIVE; Q4G0T1; -.
DR PaxDb; Q4G0T1; -.
DR PeptideAtlas; Q4G0T1; -.
DR PRIDE; Q4G0T1; -.
DR Antibodypedia; 48904; 3 antibodies from 2 providers.
DR Ensembl; ENST00000640237.1; ENSP00000491516.1; ENSG00000214279.13. [Q4G0T1-1]
DR MANE-Select; ENST00000640237.2; ENSP00000491516.1; NM_001396050.1; NP_001382979.1.
DR HGNC; HGNC:32411; SCART1.
DR HPA; ENSG00000214279; Tissue enhanced (brain).
DR neXtProt; NX_Q4G0T1; -.
DR OpenTargets; ENSG00000214279; -.
DR VEuPathDB; HostDB:ENSG00000214279; -.
DR GeneTree; ENSGT00940000162139; -.
DR OMA; CCCAGWL; -.
DR PhylomeDB; Q4G0T1; -.
DR Pharos; Q4G0T1; Tdark.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q4G0T1; protein.
DR GO; GO:0005903; C:brush border; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0002456; P:T cell mediated immunity; NAS:UniProtKB.
DR Gene3D; 3.10.250.10; -; 8.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR Pfam; PF00530; SRCR; 8.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 7.
DR SUPFAM; SSF56487; SSF56487; 8.
DR PROSITE; PS00420; SRCR_1; 1.
DR PROSITE; PS50287; SRCR_2; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunity; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1027
FT /note="Scavenger receptor cysteine-rich domain-containing
FT protein SCART1"
FT /id="PRO_0000399392"
FT TOPO_DOM 20..906
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 907..927
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 928..1027
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 28..128
FT /note="SRCR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 135..227
FT /note="SRCR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 232..326
FT /note="SRCR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 328..428
FT /note="SRCR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 434..534
FT /note="SRCR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 555..656
FT /note="SRCR 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 661..761
FT /note="SRCR 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DOMAIN 786..886
FT /note="SRCR 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 53..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 66..127
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 97..107
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 160..216
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 171..226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 196..206
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 253..315
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 266..325
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 297..307
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 353..417
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 366..427
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 397..407
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 472..533
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 503..513
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 594..655
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 625..635
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 824..885
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT DISULFID 855..865
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00196"
FT VAR_SEQ 226..324
FT /note="Missing (in isoform Alpha)"
FT /evidence="ECO:0000303|PubMed:22795646"
FT /id="VSP_053841"
FT VAR_SEQ 229..232
FT /note="HTEA -> EAAT (in isoform Gamma)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039839"
FT VAR_SEQ 233..1027
FT /note="Missing (in isoform Gamma)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039840"
FT VAR_SEQ 657..935
FT /note="Missing (in isoform Alpha)"
FT /evidence="ECO:0000303|PubMed:22795646"
FT /id="VSP_053842"
FT CONFLICT 89
FT /note="Q -> K (in Ref. 3; BC038300)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="R -> G (in Ref. 3; BC038300)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1027 AA; 108611 MW; 6E956AC67ECDA48D CRC64;
MRAALWTLGL GPLLLNLWAV PIGGPGALRL AYRHSTCDGV VLVRHHGAWG YVCNQEWTLA
EASVVCRQLG CGPAVGAPKY VPLPGEMAQP WLHNVSCRGN ESSLWECSLG SWCQSPCPHA
WVVVALCSNG TFRELRLVKG RSPCAGLPEI RNVNGVDRLC VLHVEEAMVF CRELGCGPVL
QAPRRDVGVV RKYLACRGTE PTIRSCRLDN NFRSGCDLRL DAEVVCSGHT EARLVGGEHP
CAGRLEVTWG TVCDAALDLA TAHVVCRELQ CGAVVSTPEG ARFGRGSGPV WTEAFRCAGN
ESLLFHCPRG RGSQCGHGHD AGLRCSEFRM VNGSSSCEGR VEFQVQGSWA PLCATHWDIA
DATVLCHQLN CGNAVAAPGG GHFGDGDAAI WPDAFHCEGT ESYLWNCPVS TLGAPACAPG
NTASAVCSGL AHALRLREGQ SRCDGRVEVS LDGVWGRVLD DAWDLRGAGV VCRQLGCRGA
QQAYDAPAPS RGSVQVALSR VRCLGTETRL TQCNVSATLQ EPAGTSRDAG VVCSGEVGTA
SPMARRHGIP GALTLSLHRE PQGAAGRGAG ALHGGAWGTV CDDAWDLRDA HVVCRQLGCG
RALSALGAAH FGAGAGRIWL DELGCQGHES ALWQCPSAGW GRHDWRHKED AGVFCSESVA
LRLRGGTCCC AGWLDVFYNG TWGAMCSNAL KDLSLSIICK QLGCGVWGVG LAGEQALPLC
GHRDRLGGQH RVPQAAQLHS VAMPFPPMAP ALLRPSRAGL SEDRPQAAGE PLNCSSWLGC
PEEGALRVRG GEDRCSGRVE LWHAGSWGTV CDDGWDLADA EVVCRQLGCG RAVAALGAAA
FGPGSGPVWL DEVGCRGSEA SLWGCPAERW GRGDRAHEED AGVRCWEPGP GPPLPAAPFR
TFWVVSVVLG SLLGLLLLGL MAFLILPRVT QAMQRGLGRS EVSPGEAIYD VIGEMPPAGL
YEEIMEAEAV LQDEEDGSVV KVDTEAAVSG EVSNLLEGQS IRAEGGHSRP VSQGYDEAAF
PLEEMTL
