SRD1_YEAST
ID SRD1_YEAST Reviewed; 221 AA.
AC P09007; D6VR26; P09008; Q06989;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Pre-rRNA-processing protein SRD1;
DE AltName: Full=Suppressor of rRNA-processing defect protein 1;
GN Name=SRD1; OrderedLocusNames=YCR018C; ORFNames=YCR18C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CN31C, and S288c / GRF88;
RX PubMed=2825123; DOI=10.1093/nar/15.21.8963;
RA Warmington J.R., Green R.P., Newlon C.S., Oliver S.G.;
RT "Polymorphisms on the right arm of yeast chromosome III associated with Ty
RT transposition and recombination events.";
RL Nucleic Acids Res. 15:8963-8982(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [3]
RP SEQUENCE REVISION TO 106 AND C-TERMINUS.
RA Valles G., Volckaerts G.;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP FUNCTION.
RX PubMed=2179050; DOI=10.1093/genetics/124.3.497;
RA Fabian G.R., Hess S.M., Hopper A.K.;
RT "SRD1, a Saccharomyces cerevisiae suppressor of the temperature-sensitive
RT pre-rRNA processing defect of rrp1-1.";
RL Genetics 124:497-504(1990).
RN [6]
RP CHARACTERIZATION.
RX PubMed=8165142; DOI=10.1093/nar/22.7.1265;
RA Hess S.M., Stanford D.R., Hopper A.K.;
RT "SRD1, a S. cerevisiae gene affecting pre-rRNA processing contains a C2/C2
RT zinc finger motif.";
RL Nucleic Acids Res. 22:1265-1271(1994).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [8]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Plays a direct or indirect role in pre-rRNA processing.
CC {ECO:0000269|PubMed:2179050}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 2100 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA29638.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X06322; CAA29638.1; ALT_FRAME; Genomic_DNA.
DR EMBL; X07388; CAA30298.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X59720; CAA42309.2; -; Genomic_DNA.
DR EMBL; BK006937; DAA07495.1; -; Genomic_DNA.
DR PIR; S07396; S07396.
DR PIR; S19428; S19428.
DR RefSeq; NP_009944.2; NM_001178731.1.
DR AlphaFoldDB; P09007; -.
DR BioGRID; 30997; 10.
DR STRING; 4932.YCR018C; -.
DR iPTMnet; P09007; -.
DR PaxDb; P09007; -.
DR PRIDE; P09007; -.
DR EnsemblFungi; YCR018C_mRNA; YCR018C; YCR018C.
DR GeneID; 850377; -.
DR KEGG; sce:YCR018C; -.
DR SGD; S000000611; SRD1.
DR VEuPathDB; FungiDB:YCR018C; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000181677; -.
DR HOGENOM; CLU_109054_0_0_1; -.
DR InParanoid; P09007; -.
DR BioCyc; YEAST:G3O-29333-MON; -.
DR PRO; PR:P09007; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P09007; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IGI:SGD.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00320; GATA; 1.
DR SMART; SM00401; ZnF_GATA; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW rRNA processing; Zinc; Zinc-finger.
FT CHAIN 1..221
FT /note="Pre-rRNA-processing protein SRD1"
FT /id="PRO_0000083482"
FT ZN_FING 168..193
FT /note="GATA-type"
FT REGION 101..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 106
FT /note="T -> I (in Ref. 1; CAA29638)"
FT /evidence="ECO:0000305"
FT CONFLICT 192
FT /note="P -> R (in Ref. 1; CAA30298)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 221 AA; 25514 MW; D9519E6564546687 CRC64;
MRYNNYDNSG SSFLTRVVKK SDMEKTLLLN REIDDWKSND KKKAYKERGR VYASCSFIEV
SFSQIRAVDV EKKIENAEQL RDLTRNIVKN KTSSLNEITP SKNRVTSACN SERRTTSQEA
NNLEGYHSCA QGTSRSASIT KKYSKKTTSR PKREKRQTIL PNGEIKECSK CKDTWTIQWR
SGPDQNRELC SPCGLAYGKR LKKENEKKRQ AADKRIDRNN P
