ID   SRE21_CAEEL             Reviewed;         365 AA.
AC   O45306;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Serpentine receptor class epsilon-21;
DE            Short=Protein sre-21;
GN   Name=sre-21; ORFNames=C47A10.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nematode receptor-like protein sre family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z81484; CAB03969.2; -; Genomic_DNA.
DR   PIR; T19978; T19978.
DR   RefSeq; NP_507490.2; NM_075089.2.
DR   AlphaFoldDB; O45306; -.
DR   SMR; O45306; -.
DR   PaxDb; O45306; -.
DR   PRIDE; O45306; -.
DR   EnsemblMetazoa; C47A10.4.1; C47A10.4.1; WBGene00008126.
DR   GeneID; 183529; -.
DR   KEGG; cel:CELE_C47A10.4; -.
DR   UCSC; C47A10.4; c. elegans.
DR   CTD; 183529; -.
DR   WormBase; C47A10.4; CE38053; WBGene00008126; sre-21.
DR   eggNOG; ENOG502TFMC; Eukaryota.
DR   GeneTree; ENSGT01040000241938; -.
DR   HOGENOM; CLU_073419_0_0_1; -.
DR   InParanoid; O45306; -.
DR   OMA; QSCKLIR; -.
DR   OrthoDB; 1723533at2759; -.
DR   PhylomeDB; O45306; -.
DR   PRO; PR:O45306; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:InterPro.
DR   InterPro; IPR004151; 7TM_GPCR_serpentine_rcpt_Sre.
DR   Pfam; PF03125; Sre; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..365
FT                   /note="Serpentine receptor class epsilon-21"
FT                   /id="PRO_0000104540"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   365 AA;  42319 MW;  80CC4A308702D0A0 CRC64;
     MNFQFLAIFS VRLATKEEVL DRTQESGDVN VVWVFTYNSN REFSVFEFIL INFLFLLSIF
     VTFIGVFCIG KSNIPHRNAR WIIISGMLLW LELVVSRSFV FIFQWSSDGL QSRSGLLFWA
     ALLRYHYMFF GVHTLLCITA ERAMATILLK DYETRPRVWI AAILIGANFL ISLTYAFLAV
     FQQILMKSIF IVCLAVAVVS IILLEIIYFL NRKRLDSLIR HDNTMVLYTL SIKYQLQENV
     RSCRLMRPAV VVVGAFIIML ILAECLPIIL DFSDEVQMWC NLIFDTTVHT DPLVVVPTVV
     ALMESFRKVF LSYYRTLQHK IRPNTVAVIR RKSIFPFTKP KETEGDIYFE MFNKSVSPNS
     LAVKK