ID   SRE2_CAEEL              Reviewed;         369 AA.
AC   Q09273;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 4.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Serpentine receptor class epsilon-2;
DE            Short=Protein sre-2;
GN   Name=sre-2; ORFNames=C41C4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nematode receptor-like protein sre family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z48045; CAA88099.5; -; Genomic_DNA.
DR   PIR; T19873; T19873.
DR   RefSeq; NP_495698.4; NM_063297.4.
DR   AlphaFoldDB; Q09273; -.
DR   STRING; 6239.C41C4.2; -.
DR   PaxDb; Q09273; -.
DR   EnsemblMetazoa; C41C4.2.1; C41C4.2.1; WBGene00005150.
DR   GeneID; 174302; -.
DR   KEGG; cel:CELE_C41C4.2; -.
DR   UCSC; C41C4.2; c. elegans.
DR   CTD; 174302; -.
DR   WormBase; C41C4.2; CE44368; WBGene00005150; sre-2.
DR   eggNOG; ENOG502TH80; Eukaryota.
DR   GeneTree; ENSGT00970000197419; -.
DR   HOGENOM; CLU_795071_0_0_1; -.
DR   InParanoid; Q09273; -.
DR   OMA; IWVSTYE; -.
DR   OrthoDB; 1696800at2759; -.
DR   PhylomeDB; Q09273; -.
DR   PRO; PR:Q09273; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00005150; Expressed in multicellular organism and 1 other tissue.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:InterPro.
DR   InterPro; IPR004151; 7TM_GPCR_serpentine_rcpt_Sre.
DR   Pfam; PF03125; Sre; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..369
FT                   /note="Serpentine receptor class epsilon-2"
FT                   /id="PRO_0000104535"
FT   TOPO_DOM        1..20
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..118
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        140..148
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..274
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..369
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   369 AA;  43578 MW;  54AE4884E96A7BA2 CRC64;
     MLIQYHKISN NDPNRIQLLS MIFCEIILLI FELFEFAAII FNMSRYQFHF NLKVVVGYAI
     FAYWFDIIAR ITIAFFEIGL FNLDDQTIAV ETEKLPWNYK NMFFMLLFCC STYRVYFMFL
     ICSVTLLLAV ERFLATIWVS TYESVQHKWV SIVLTSTNSI AGIFGSLLFH YELIFDTAVW
     CSLGLCFNFV SIFLYVILFN SNKSKIELCQ TREITQSYTL SLRFQLNENL KIMNWIKNSI
     LVVTCFNTLL AGFLIASNNE YLKNDYPVLV KCCHTFLNLG IAIYAQVVFF VAILADRHFR
     TYFLRFKPIR VFTKPFFGRI FPEDFKIKKI LSTSDETNVY FSKLSLQWDE QIIRSSHVVV
     AKKKRFWRV