SRE2_SCHPO
ID SRE2_SCHPO Reviewed; 793 AA.
AC O43019;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Putative transcription factor sre2;
DE AltName: Full=Sterol regulatory element-binding protein 2;
GN Name=sre2; ORFNames=SPBC354.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PREDICTED FUNCTION.
RX PubMed=11790253; DOI=10.1186/gb-2001-2-12-research0050;
RA Zupicich J., Brenner S.E., Skarnes W.C.;
RT "Computational prediction of membrane-tethered transcription factors.";
RL Genome Biol. 2:RESEARCH0050.1-RESEARCH0050.6(2001).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344; SER-345; SER-355 AND
RP TYR-356, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Putative transcription factor.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000305|PubMed:16823372}. Membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}. Note=May be released from membranes by
CC a process known as regulated intramembrane proteolysis (RIP).
CC -!- PTM: May undergo proteolytic cleavage to release the soluble
CC transcription factor from the membrane.
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DR EMBL; CU329671; CAA17805.1; -; Genomic_DNA.
DR PIR; T40285; T40285.
DR RefSeq; NP_595229.1; NM_001021135.2.
DR AlphaFoldDB; O43019; -.
DR SMR; O43019; -.
DR BioGRID; 277559; 210.
DR STRING; 4896.SPBC354.05c.1; -.
DR iPTMnet; O43019; -.
DR MaxQB; O43019; -.
DR PaxDb; O43019; -.
DR PRIDE; O43019; -.
DR EnsemblFungi; SPBC354.05c.1; SPBC354.05c.1:pep; SPBC354.05c.
DR GeneID; 2541044; -.
DR KEGG; spo:SPBC354.05c; -.
DR PomBase; SPBC354.05c; sre2.
DR VEuPathDB; FungiDB:SPBC354.05c; -.
DR eggNOG; KOG2588; Eukaryota.
DR HOGENOM; CLU_354177_0_0_1; -.
DR InParanoid; O43019; -.
DR PRO; PR:O43019; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; ISM:PomBase.
DR GO; GO:0005634; C:nucleus; IC:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISM:PomBase.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISM:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; NAS:PomBase.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..793
FT /note="Putative transcription factor sre2"
FT /id="PRO_0000356242"
FT TRANSMEM 719..739
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 748..768
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 426..495
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 323..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 344
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 345
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 356
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 793 AA; 86834 MW; B9A4E0BBFA79C3A5 CRC64;
MCPSQHSSLK DIHRQLENTA ISNPTENADP SSYVDGSNIM DFKHPSIVSS SASSSYPISH
VPSVGTRGIP RSYSMASAYP YQVNSNSMDA STAFNLNQDV ADKPMLARNS IDSSINTELG
PLESNHWFTQ AQDHSRQYSS SWDPSIDPFE VKNSLHDSTD LSITHHPHLP INHQGNTWKH
ANESLQSNQG PVPNTKFVGL ETTQTDSYQQ SSVNSVVKIE EADATYALRE ESGQFNTFTG
AENPSISPHS LNPNFPQYTE KPALTLLQSP KQNSNYDTSN FQNSVSDSSM QFTNEGMPSP
VKGIMSSDDA VAFNFSQYST VYPQNAPENG NEFETPNKLK RTVSSPCASI SSKRSYGDIA
QDCSYISSKT NGGGPSDSPS SSSTSVRGSV NDSNSPISSS ATFAIQSNGV EPVGLSTQEQ
NLSPLSKRSA HNMIEKRYRS NLNDKIAELR DAVPTLRSGY NSTTADELKG TYVPLSRKLN
KATILSKATE YIKSLQSKNK KLIEENKILQ KRLSEYTSVI QASLTAPSQP ASLSLLGPPG
NTPGHRNVPP ILKRSSIGTP SQQAYFPDAP HNCHSVPQNS SYPRPPMQVN RSPIDSMQTI
PHANFNEMHN AYSSRYPLKY SKSCNAVSHT SMMHPQEYGG SLPSSTVPSD YNQPQLVSPR
AQADQQGLSY KNVGRAVLNG LVGLETVHML TNPDDAGSSN RFSMSVLPIS PSLHSILRFL
LLLLAFLCFA MHILLTPEAT LRKWASSIYL SFRLECVFIS FLIFSVPIYD WGNYLNLRGK
LLSELNLESG VAT
