ID   SREA_COCH4              Reviewed;         520 AA.
AC   N4XMB0;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=GATA-type transcription factor SRE1 {ECO:0000303|PubMed:23980626};
DE   AltName: Full=Siderophore uptake regulator SRE1 {ECO:0000303|PubMed:23980626};
GN   Name=SRE1 {ECO:0000303|PubMed:23980626}; ORFNames=COCC4DRAFT_135674;
OS   Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern
OS   corn leaf blight fungus) (Bipolaris maydis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX   NCBI_TaxID=665024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C4 / ATCC 48331 / race T;
RX   PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA   Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA   Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA   LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA   Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA   Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA   Grigoriev I.V.;
RT   "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT   genomes of eighteen Dothideomycetes fungi.";
RL   PLoS Pathog. 8:E1003037-E1003037(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C4 / ATCC 48331 / race T;
RX   PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA   Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA   Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA   Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA   LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA   Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT   "Comparative genome structure, secondary metabolite, and effector coding
RT   capacity across Cochliobolus pathogens.";
RL   PLoS Genet. 9:E1003233-E1003233(2013).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=23980626; DOI=10.1094/mpmi-02-13-0055-r;
RA   Zhang N., MohdZainudin N.A., Scher K., Condon B.J., Horwitz B.A.,
RA   Turgeon B.G.;
RT   "Iron, oxidative stress, and virulence: roles of iron-sensitive
RT   transcription factor Sre1 and the redox sensor ChAp1 in the maize pathogen
RT   Cochliobolus heterostrophus.";
RL   Mol. Plant Microbe Interact. 26:1473-1485(2013).
CC   -!- FUNCTION: GATA-type transcription repressor that regulates
CC       iron- acquisition genes through specific binding the GATA sequence
CC       elements of target promoters (PubMed:23980626). SRE1 targets repressed
CC       under iron-replete conditions include genes encoding a number of key
CC       iron-regulated factors such as those involved in siderophore
CC       biosynthesis NPS6, SIDA2 and ABC6, as well as the high-affinity iron
CC       permease FTR1, the catalase CAT1, and the superoxide dismutase SOD1
CC       encoding genes (PubMed:23980626). {ECO:0000269|PubMed:23980626}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The conserved cystein-rich region (CRR) localized between the
CC       zinc fingers is also involved in DNA-binding and transcription
CC       repressor activity (By similarity). {ECO:0000250|UniProtKB:Q1K8E7}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the repression of siderophore
CC       biosynthesis and utilization genes in the presence of abundant iron and
CC       thus produces siderophores even under iron-replete conditions
CC       (PubMed:23980626). {ECO:0000269|PubMed:23980626}.
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DR   EMBL; KB733452; ENI06272.1; -; Genomic_DNA.
DR   RefSeq; XP_014080181.1; XM_014224706.1.
DR   AlphaFoldDB; N4XMB0; -.
DR   EnsemblFungi; ENI06272; ENI06272; COCC4DRAFT_135674.
DR   GeneID; 25837414; -.
DR   HOGENOM; CLU_021761_0_1_1; -.
DR   OrthoDB; 1466754at2759; -.
DR   PHI-base; PHI:3837; -.
DR   Proteomes; UP000012338; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; -; 2.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; PTHR10071; 2.
DR   Pfam; PF00320; GATA; 2.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Metal-binding; Nucleus; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..520
FT                   /note="GATA-type transcription factor SRE1"
FT                   /id="PRO_0000444404"
FT   ZN_FING         131..155
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         287..311
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          168..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..239
FT                   /note="Cystein-rich region (CRR)"
FT                   /evidence="ECO:0000250|UniProtKB:Q1K8E7"
FT   REGION          326..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..447
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          486..520
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        21..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        406..427
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..485
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   520 AA;  55967 MW;  07AFA358D1E46050 CRC64;
     MAHPSGSGGT SFAPTPTHPH HLSRETSRDE LEMAESLRLL NQTHDHQKPR AEATSQEQQQ
     QQQQQQQQQQ QQQQQQQQQH AQEDPRSEIY HSLEDAVPIA DGPPTPSTAA SLQIPNMNYE
     TPNASITGQV CSNCKTTQTP LWRRSPAGET VCNACGLYMK ARNQSRPVNL KRNTQTQPTM
     SVQQSPTPGS TDGSRTCAGN VAGSPRVATY VAADQMAAGT CPGGGRCNGT GGQQGCSGCP
     AFNNRVSKTA KFALAQANAA PGENRGGSDA ASSTSAASAS TSAIPACQNC GTTITPLWRR
     DDAGHIICNA CGLYYKLHGT HRPVAMKKQE IKRRKRIVPA ADTSSQAPSS VANYSPPQRP
     SQTPAFEHSV SPDPSTALES REAYTPEPPR GPIAVDFTHY YSNSSVTSNP VALTPTVQPS
     APSPRKRSRS ATLDPEEPVN PLPHRPNAIS AILNPSQTEV DANIDPSLSV PLRTSGGTSP
     NFTLSPEEKA AKRERLKREA EAMRLELERR QKELEELEND