SRF1_ARATH
ID SRF1_ARATH Reviewed; 775 AA.
AC Q06BH3; Q06BH2; Q06BH4; Q93ZY8; Q9MAS2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Protein STRUBBELIG-RECEPTOR FAMILY 1;
DE AltName: Full=Leucine-rich repeat receptor kinase-like protein SRF1;
DE Flags: Precursor;
GN Name=SRF1; OrderedLocusNames=At2g20850; ORFNames=F5H14.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A AND B), POLYMORPHISM,
RP FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=17397538; DOI=10.1186/1471-2229-7-16;
RA Eyueboglu B., Pfister K., Haberer G., Chevalier D., Fuchs A., Mayer K.F.X.,
RA Schneitz K.;
RT "Molecular characterisation of the STRUBBELIG-RECEPTOR FAMILY of genes
RT encoding putative leucine-rich repeat receptor-like kinases in Arabidopsis
RT thaliana.";
RL BMC Plant Biol. 7:16-16(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-775.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17027738; DOI=10.1016/j.ydbio.2006.09.009;
RA Kwak S.-H., Schiefelbein J.;
RT "The role of the SCRAMBLED receptor-like kinase in patterning the
RT Arabidopsis root epidermis.";
RL Dev. Biol. 302:118-131(2007).
CC -!- FUNCTION: Not essential for epidermal patterning and not redundant with
CC STRUBBELIG. {ECO:0000269|PubMed:17027738, ECO:0000269|PubMed:17397538}.
CC -!- INTERACTION:
CC Q06BH3; Q94F62: BAK1; NbExp=2; IntAct=EBI-16955764, EBI-617138;
CC Q06BH3; Q6XAT2: ERL2; NbExp=2; IntAct=EBI-16955764, EBI-16895926;
CC Q06BH3; C0LGQ5: GSO1; NbExp=2; IntAct=EBI-16955764, EBI-16905069;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Comment=Alternative splicing was observed in all tissues.;
CC Name=A;
CC IsoId=Q06BH3-1; Sequence=Displayed;
CC Name=B;
CC IsoId=Q06BH3-2; Sequence=VSP_029608, VSP_029609;
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves and flowers. Low
CC expression in seedlings and siliques. {ECO:0000269|PubMed:17397538}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- DISRUPTION PHENOTYPE: Plants do not show root phenotype alteration.
CC {ECO:0000269|PubMed:17027738}.
CC -!- MISCELLANEOUS: Over-expression of SRF1B induces no obvious phenotypes
CC while overexpression of SRF1A may lead to seedling lethality in both
CC cv. Landsberg and cv. Columbia.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20910.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAR99869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ914917; ABI81608.1; -; Genomic_DNA.
DR EMBL; DQ914917; ABI81609.1; -; Genomic_DNA.
DR EMBL; DQ914918; ABI81610.1; -; mRNA.
DR EMBL; DQ914919; ABI81611.1; -; mRNA.
DR EMBL; DQ914920; ABI81612.1; -; mRNA.
DR EMBL; AY518286; AAR99869.1; ALT_INIT; mRNA.
DR EMBL; AC006234; AAD20910.3; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC07087.1; -; Genomic_DNA.
DR EMBL; AY056176; AAL07025.1; -; mRNA.
DR EMBL; BT001939; AAN71938.1; -; mRNA.
DR PIR; B84594; B84594.
DR RefSeq; NP_565489.2; NM_127654.4. [Q06BH3-1]
DR AlphaFoldDB; Q06BH3; -.
DR SMR; Q06BH3; -.
DR BioGRID; 1971; 28.
DR IntAct; Q06BH3; 30.
DR STRING; 3702.AT2G20850.1; -.
DR iPTMnet; Q06BH3; -.
DR PaxDb; Q06BH3; -.
DR PRIDE; Q06BH3; -.
DR ProteomicsDB; 226723; -. [Q06BH3-1]
DR EnsemblPlants; AT2G20850.1; AT2G20850.1; AT2G20850. [Q06BH3-1]
DR GeneID; 816618; -.
DR Gramene; AT2G20850.1; AT2G20850.1; AT2G20850. [Q06BH3-1]
DR KEGG; ath:AT2G20850; -.
DR Araport; AT2G20850; -.
DR TAIR; locus:2051404; AT2G20850.
DR eggNOG; ENOG502QR8F; Eukaryota.
DR HOGENOM; CLU_000288_92_2_1; -.
DR InParanoid; Q06BH3; -.
DR OMA; NFRPPIV; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; Q06BH3; -.
DR PRO; PR:Q06BH3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q06BH3; baseline and differential.
DR Genevisible; Q06BH3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR045271; SRF-like.
DR PANTHER; PTHR27001; PTHR27001; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Leucine-rich repeat; Membrane;
KW Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..775
FT /note="Protein STRUBBELIG-RECEPTOR FAMILY 1"
FT /id="PRO_0000311841"
FT TOPO_DOM 32..314
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..775
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 101..122
FT /note="LRR 1"
FT REPEAT 123..146
FT /note="LRR 2"
FT REPEAT 147..169
FT /note="LRR 3"
FT REPEAT 171..193
FT /note="LRR 4"
FT REPEAT 195..217
FT /note="LRR 5"
FT REPEAT 218..238
FT /note="LRR 6"
FT DOMAIN 478..756
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 254..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..396
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 192
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 382..420
FT /note="DKEARPKERVGGASKLHGGAERSVGSESKQESHEIDMNG -> GEISYLDFF
FT TFRFQESHMFVFSSSMKFKQKTRRLDQKRE (in isoform B)"
FT /evidence="ECO:0000303|PubMed:17397538"
FT /id="VSP_029608"
FT VAR_SEQ 421..775
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:17397538"
FT /id="VSP_029609"
FT VARIANT 195
FT /note="T -> N (in strain: cv. Landsberg erecta)"
FT VARIANT 282
FT /note="A -> T (in strain: cv. Landsberg erecta)"
FT VARIANT 361
FT /note="R -> K (in strain: cv. Landsberg erecta)"
FT VARIANT 386
FT /note="R -> K (in strain: cv. Landsberg erecta)"
FT VARIANT 395
FT /note="S -> L (in strain: cv. Landsberg erecta)"
FT VARIANT 398
FT /note="H -> Q (in strain: cv. Landsberg erecta)"
FT VARIANT 408
FT /note="E -> K (in strain: cv. Landsberg erecta)"
FT VARIANT 420
FT /note="G -> D (in strain: cv. Landsberg erecta)"
FT VARIANT 442
FT /note="T -> N (in strain: cv. Landsberg erecta)"
FT VARIANT 451..453
FT /note="RTT -> KTS (in strain: cv. Landsberg erecta)"
FT VARIANT 477
FT /note="S -> N (in strain: cv. Landsberg erecta)"
FT VARIANT 480
FT /note="H -> L (in strain: cv. Landsberg erecta)"
FT VARIANT 503
FT /note="F -> L (in strain: cv. Landsberg erecta)"
FT VARIANT 506
FT /note="R -> K (in strain: cv. Landsberg erecta)"
FT VARIANT 522
FT /note="L -> V (in strain: cv. Landsberg erecta)"
FT VARIANT 567
FT /note="I -> T (in strain: cv. Landsberg erecta)"
FT VARIANT 579
FT /note="V -> I (in strain: cv. Landsberg erecta)"
FT VARIANT 583
FT /note="I -> M (in strain: cv. Landsberg erecta)"
FT VARIANT 600
FT /note="P -> L (in strain: cv. Landsberg erecta)"
FT VARIANT 605
FT /note="R -> Q (in strain: cv. Landsberg erecta)"
FT VARIANT 618
FT /note="I -> M (in strain: cv. Landsberg erecta)"
FT VARIANT 708
FT /note="A -> E (in strain: cv. Landsberg erecta)"
FT VARIANT 741
FT /note="Y -> F (in strain: cv. Landsberg erecta)"
FT VARIANT 773
FT /note="G -> R (in strain: cv. Landsberg erecta)"
FT VARIANT Q06BH3-2:397
FT /note="S -> N (in strain: cv. Landsberg erecta)"
FT /evidence="ECO:0000305"
FT VARIANT Q06BH3-2:404
FT /note="S -> P (in strain: cv. Landsberg erecta)"
FT /evidence="ECO:0000305"
FT VARIANT Q06BH3-2:416
FT /note="D -> N (in strain: cv. Landsberg erecta)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 775 AA; 84824 MW; 06FDACFC10DD2F9E CRC64;
MRSMRSGRDN NICFLGFLSF ALISLPSLSL ALTNPDDVAA INSLFLALES PLLPGWVASG
GDPCGESWQG VLCNASQVET IILISANLGG ELGVGLNMFT SLKAMDFSNN HIGGSIPSTL
PVSLQNLFLS GNNFTGTIPE SLSSLKSLSV MSLNNNLLSG KIPDVFQDLG LMINIDLSSN
NLSGPLPPSM QNLSTLTSLL LQNNHLSGEL DVLQDLPLKD LNVENNLFNG PIPEKLLSIP
NFIKGGNLFN VTIAPSPSPE TPPSPTSPKR PFFGPPSPNA SAGHGQAHVR SPPSDHHPSR
PTPQGKEDSF TSKRIIWISI LGAFSFVVLA LVCLLCGRKC LRKREDSEQL SKPHLTSEYG
RAREGSRSNA SMLPPSNTFN KDKEARPKER VGGASKLHGG AERSVGSESK QESHEIDMNG
NAMDLMHPSS IPPIKRVIAK ATEPAEASLK RTTSKSHGPL TAVKHFTVAS LQQHTNSFSH
ENLIGTGMLG SVYRAELPGG KLFAVRKLDK KSPNHEEEGK FLELVNNIDR IRHANIVQLV
GFCSEHSQRL LIHEYCRNGT LHDLLHIDDR LKIELSWNVR VRIALEAAKA LEYLHEICDP
PSIHRNFKSA NILLDDDIRV HVSDCGLAPL ISSGAVSQLS GQLLAAYGYG APEFEYGIYT
MKCDVYSFGV VMLELLTGRK SYDKKRDRGE QFLVRWAIPQ LHDIDALAKM VDPSLKGDYP
AKSLSHFADV ISRCVQSEPE YRPLMSEVVQ DLSDMIQREH RRNDSNGDNQ YTGRR
