SRF2_ARATH
ID SRF2_ARATH Reviewed; 735 AA.
AC Q9FG24;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Protein STRUBBELIG-RECEPTOR FAMILY 2;
DE AltName: Full=Leucine-rich repeat receptor kinase-like protein SRF2;
DE Flags: Precursor;
GN Name=SRF2; OrderedLocusNames=At5g06820; ORFNames=MPH15.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=17397538; DOI=10.1186/1471-2229-7-16;
RA Eyueboglu B., Pfister K., Haberer G., Chevalier D., Fuchs A., Mayer K.F.X.,
RA Schneitz K.;
RT "Molecular characterisation of the STRUBBELIG-RECEPTOR FAMILY of genes
RT encoding putative leucine-rich repeat receptor-like kinases in Arabidopsis
RT thaliana.";
RL BMC Plant Biol. 7:16-16(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- INTERACTION:
CC Q9FG24; Q8VYT3: At4g30520; NbExp=2; IntAct=EBI-16955365, EBI-16902452;
CC Q9FG24; Q6XAT2: ERL2; NbExp=2; IntAct=EBI-16955365, EBI-16895926;
CC Q9FG24; Q9FG24: SRF2; NbExp=2; IntAct=EBI-16955365, EBI-16955365;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, stems, leaves,
CC flowers and siliques. {ECO:0000269|PubMed:17397538}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:17397538}.
CC -!- MISCELLANEOUS: Cannot functionally replace STRUBBELIG.
CC -!- MISCELLANEOUS: Over-expression of SRF2 led to male-sterility in cv.
CC Columbia but not in cv. Landsberg.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR EMBL; AY518287; AAR99870.1; -; mRNA.
DR EMBL; AP002032; BAB09817.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91070.1; -; Genomic_DNA.
DR RefSeq; NP_196300.1; NM_120765.3.
DR AlphaFoldDB; Q9FG24; -.
DR SMR; Q9FG24; -.
DR BioGRID; 15852; 54.
DR IntAct; Q9FG24; 53.
DR STRING; 3702.AT5G06820.1; -.
DR PaxDb; Q9FG24; -.
DR PRIDE; Q9FG24; -.
DR EnsemblPlants; AT5G06820.1; AT5G06820.1; AT5G06820.
DR GeneID; 830573; -.
DR Gramene; AT5G06820.1; AT5G06820.1; AT5G06820.
DR KEGG; ath:AT5G06820; -.
DR Araport; AT5G06820; -.
DR TAIR; locus:2170219; AT5G06820.
DR eggNOG; ENOG502QR3N; Eukaryota.
DR HOGENOM; CLU_000288_92_2_1; -.
DR InParanoid; Q9FG24; -.
DR OMA; RPPMTVI; -.
DR OrthoDB; 684563at2759; -.
DR PhylomeDB; Q9FG24; -.
DR PRO; PR:Q9FG24; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FG24; baseline and differential.
DR Genevisible; Q9FG24; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Leucine-rich repeat; Membrane; Receptor; Reference proteome;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..735
FT /note="Protein STRUBBELIG-RECEPTOR FAMILY 2"
FT /id="PRO_0000311842"
FT TOPO_DOM 24..297
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..735
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 78..94
FT /note="LRR 1"
FT REPEAT 96..119
FT /note="LRR 2"
FT REPEAT 120..140
FT /note="LRR 3"
FT REPEAT 142..163
FT /note="LRR 4"
FT REPEAT 165..187
FT /note="LRR 5"
FT REPEAT 189..211
FT /note="LRR 7"
FT REPEAT 212..232
FT /note="LRR 7"
FT REPEAT 233..253
FT /note="LRR 8"
FT DOMAIN 415..695
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 358..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 735 AA; 81299 MW; 1330848327280703 CRC64;
MKTKQQLRFL ATILLTTILF VLAKTDTDPL EVLALQDLYK SLRNPEQLRG WRLEGGDPCG
EAWLGISCSG SSIVDLQLRE LKLLGSLGNQ LQHLHNLKIL DVSFNNLEGE IPFGLPPNAT
HINMAYNNLT QSIPFSLPLM TSLQSLNLSH NSLSGPLGNV FSGLQIKEMD LSFNNLTGDL
PSSFGTLMNL TSLYLQNNRL TGSVIYLADL PLADLNIEDN QFSGIIPSHF QSIPHLWIWG
NKFHVEPNYK PWKFPLDVRP LIQNDTGYPT TESSAIMNFP RPETQKVKKK KKGIGAGSTF
LLVGGLALLG TFFALFAVRM NHRRAQNLAA IHRSNNSIAY SLPVSTGREY PVATEDNPQI
KRFQPPPAPQ LRHLPSPPVR IDKSARRKSF SATCQYPSFA KLFSAAELQL ATNCFSEENL
LGEGPLGSVY RAKLPDGQFA VVRNIPMSSL SLHEEEQFTE VLQTASKLRH PNIVTLLGFC
IENGEHLLVY EYVGHLSLYN AMHDEVYKPL SWGLRLRIAI GVARALDYLH SSFCPPIAHS
DLKATNILLD EELTPRIADC GLASLRPLTS NSVKLRASEI AIQNTGYIAP EHGQPGSSGT
KSDTYALGVL LLELLTGRKA FDSSRPRGEQ LLVKWASTRL HDRRSLEQMI DGGIAGTFSS
RVASQYADII SLCTQAEKEF RPPVSEIVEA LTALIQKQNK EASSSVADKT DPFSKSFCST
RTRFISSPTF SYLSS
