ID   SRFB1_XENTR             Reviewed;         535 AA.
AC   Q5XGC9; Q28EI0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Serum response factor-binding protein 1;
DE   AltName: Full=SRF-dependent transcription regulation-associated protein;
GN   Name=srfbp1 {ECO:0000312|EMBL:AAH84513.1}; ORFNames=TTpA001g14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82958.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Tadpole {ECO:0000312|EMBL:CAJ82958.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82958.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH84513.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in regulating transcriptional activation of
CC       cardiac genes during the aging process. May play a role in biosynthesis
CC       and/or processing of SLC2A4 in adipose cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q9CZ91}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q9CZ91}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5XGC9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5XGC9-2; Sequence=VSP_031567;
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DR   EMBL; CR848244; CAJ82958.1; -; mRNA.
DR   EMBL; BC084513; AAH84513.1; -; mRNA.
DR   RefSeq; NP_001011115.1; NM_001011115.1. [Q5XGC9-1]
DR   AlphaFoldDB; Q5XGC9; -.
DR   SMR; Q5XGC9; -.
DR   GeneID; 496528; -.
DR   KEGG; xtr:496528; -.
DR   CTD; 153443; -.
DR   Xenbase; XB-GENE-941165; srfbp1.
DR   InParanoid; Q5XGC9; -.
DR   OrthoDB; 1397283at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR   InterPro; IPR037393; Bud22/SRFB1.
DR   InterPro; IPR015158; Bud22_dom.
DR   PANTHER; PTHR23325; PTHR23325; 1.
DR   Pfam; PF09073; BUD22; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..535
FT                   /note="Serum response factor-binding protein 1"
FT                   /id="PRO_0000320010"
FT   REGION          128..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..27
FT                   /evidence="ECO:0000255"
FT   COILED          107..177
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        128..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..361
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..385
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        408..429
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..535
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         320..324
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_031567"
SQ   SEQUENCE   535 AA;  61009 MW;  695FCA3AD60308A3 CRC64;
     MEPVLNLNNE VVKLRKDVKK VKVLIIRKLT RHIAKLKSKK GTEELILKNQ RRAQRLLEEI
     HSVKELKPDD VTKTALRKEI SFEKVCKKPN STAEERALAR LATHPLLKQK ITAIKEAIKA
     FKDARKTAAE GEREREKDEP EQVTKIKETK KPVQAKLNKN TEEIKSAKEH VKEEKCKNLL
     EDSDKGTEKA LELPYVQENL PEQTAENKEQ PKAQDVERPA VERPAVERPA VERPAVERPA
     VERPAVERPA VERPAVERPA VERPAVERPA VERPAVERPA VERPAVERPA VERPAVERPA
     VERPAVERPA VERPAVERPA VERPVVESPA VERPPVESPP KKKACLEQEL GCELSDIEDS
     DKEKEYFDDS TEERFYKHSS SFEDSDSGSD NDFFIGKIRR TKKKKSDKDG SKQKEEKVPP
     TKEKAQTSEV QKEIPTAKSM KLKSVFCKSL SQTKPKPSFT KRETNFRQER NKRPVMPQAS
     PLAKKPLQSK ATSVRQPGRK LEAQPLHPSW EASRKRKEQQ AQITKFQGKK IVFDD