ID   SRFB_DICDI              Reviewed;         467 AA.
AC   Q54RY6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Serum response factor homolog B;
GN   Name=srfB; ORFNames=DDB_G0282835;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
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DR   EMBL; AAFI02000047; EAL65997.1; -; Genomic_DNA.
DR   RefSeq; XP_639351.1; XM_634259.1.
DR   AlphaFoldDB; Q54RY6; -.
DR   SMR; Q54RY6; -.
DR   STRING; 44689.DDB0220492; -.
DR   PaxDb; Q54RY6; -.
DR   EnsemblProtists; EAL65997; EAL65997; DDB_G0282835.
DR   GeneID; 8623792; -.
DR   KEGG; ddi:DDB_G0282835; -.
DR   dictyBase; DDB_G0282835; srfB.
DR   eggNOG; KOG0015; Eukaryota.
DR   HOGENOM; CLU_585852_0_0_1; -.
DR   InParanoid; Q54RY6; -.
DR   PRO; PR:Q54RY6; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:dictyBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0140582; P:adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway; IMP:dictyBase.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IEP:dictyBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:dictyBase.
DR   CDD; cd00266; MADS_SRF_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033897; MADS_SRF-like.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS00350; MADS_BOX_1; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..467
FT                   /note="Serum response factor homolog B"
FT                   /id="PRO_0000327939"
FT   DOMAIN          36..96
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  51218 MW;  EF96B44826E8688B CRC64;
     MELNMNQYDN IESNDSPPTP SSPGEEGNVE KKEKKSGRRK INIEFIGDKS RRHITFSKRK
     SGIMKKAYEL STLTGTQVLL IVASETGHVY TFATPKLQPL ITKQEGKTLI QACLNTPDVP
     PVSKDDGNNN NGNNSNNNNN SNNNNSSNNN NNGNNNNGNT NNNNGNNNNS NNNNSGNNNN
     NNNNNSYNNN NNNNNNNNNN NNNNNCKEEQ NMNIPNERKS KNNINNNNNN QNNNQNNNQN
     NNNLTQPIQN LQLPLQQNII AQQQQQLNQQ AALQQQMTQQ IDQKLYNLQL QQQQMQQQQQ
     IQNISGGSGN NSNGYINGNG MNGNNNNNNN SNNIPEYGQV IIQSYRGSNS GGNNSSNNTS
     TNTNTNTNTN TNNNNNNSNS SNGNNSNNNS NNILPQNLTT PSPIISQPLP SIPSPSSSSS
     NIGNSGYSSP FSTSFSYGGY QQPFSRNYPL QSNIATNSTV SKAPSDL