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SRFD_DICDI
ID   SRFD_DICDI              Reviewed;         446 AA.
AC   Q54QY7;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Serum factor response D;
GN   Name=srfD; ORFNames=DDB_G0283483;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251}.
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DR   EMBL; AAFI02000055; EAL65726.1; -; Genomic_DNA.
DR   RefSeq; XP_639104.1; XM_634012.1.
DR   AlphaFoldDB; Q54QY7; -.
DR   SMR; Q54QY7; -.
DR   STRING; 44689.DDB0220493; -.
DR   PaxDb; Q54QY7; -.
DR   EnsemblProtists; EAL65726; EAL65726; DDB_G0283483.
DR   GeneID; 8624128; -.
DR   KEGG; ddi:DDB_G0283483; -.
DR   dictyBase; DDB_G0283483; srfD.
DR   eggNOG; KOG0014; Eukaryota.
DR   HOGENOM; CLU_614570_0_0_1; -.
DR   InParanoid; Q54QY7; -.
DR   OMA; KRKCINE; -.
DR   PRO; PR:Q54QY7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..446
FT                   /note="Serum factor response D"
FT                   /id="PRO_0000389012"
FT   DOMAIN          1..61
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   REGION          95..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..123
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..195
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  50225 MW;  0AA9F71D937AEC0A CRC64;
     MGRKKIKIQR IPDERNRQVT FNKRKNGLIK KAMELALLCD STVSLVIVNN SPNAKEKYFQ
     YISSGLPSPM ESIPDLGPEI SQKFTDHDYD KIFNKKEKGD FNDDYIGGDT ASHSEEEDHK
     SPSSTPELLG YNHHNHHHHH HQYNNNSNNN NNNHNNNHNN YNNSNNINGH NNHYNHNNLK
     LNSNNNNNNS QFNSSQHINK PILSIKPSQT QENHNHYNNY SSHLSNNNNN NNSSNNNNNS
     NNNNNNNNNN NTNNNNTNNN NNNNNNNNNN NNNNNNNNNN NNMSPIGSPP SKCQQVPAFD
     STQATQALLS LHNASKLFCS SPEDTSPMTS PRTPPFSSTN TNTLQTSPNS QQKSKSLPPL
     IFNENNNQNN NNQNNNQNNN NNNSNNTNTN NNNQNNSSRS ILLPPISLYN SNSNSNSSST
     LTSPTSSSSN LNDDLFLKKR KLELIH
 
 
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