SRF_CHICK
ID SRF_CHICK Reviewed; 375 AA.
AC Q90718;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Serum response factor;
DE Short=SRF;
DE Flags: Fragment;
GN Name=SRF;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8660892; DOI=10.1006/dbio.1996.0160;
RA Croissant J.D., Kim J.H., Eichele G., Goering L., Lough J., Prywes R.,
RA Schwartz R.J.;
RT "Avian serum response factor expression restricted primarily to muscle cell
RT lineages is required for alpha-actin gene transcription.";
RL Dev. Biol. 177:250-264(1996).
CC -!- FUNCTION: SRF is a transcription factor that binds to the serum
CC response element (SRE), a short sequence of dyad symmetry located 300
CC bp to the 5' of the site of transcription initiation of some genes
CC (such as FOS). Together with MRTFA transcription coactivator, controls
CC expression of genes regulating the cytoskeleton during development,
CC morphogenesis and cell migration. {ECO:0000250|UniProtKB:Q9JM73}.
CC -!- SUBUNIT: Binds DNA as a multimer, probably a dimer.
CC {ECO:0000250|UniProtKB:Q9JM73}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JM73,
CC ECO:0000255|PROSITE-ProRule:PRU00251}.
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DR EMBL; U50596; AAB09753.1; -; mRNA.
DR STRING; 9031.ENSGALP00000021614; -.
DR PaxDb; Q90718; -.
DR VEuPathDB; HostDB:geneid_396103; -.
DR eggNOG; KOG0015; Eukaryota.
DR InParanoid; Q90718; -.
DR PhylomeDB; Q90718; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0010736; F:serum response element binding; ISS:UniProtKB.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010735; P:positive regulation of transcription via serum response element binding; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00266; MADS_SRF_like; 1.
DR Gene3D; 3.40.1810.10; -; 1.
DR InterPro; IPR033897; MADS_SRF-like.
DR InterPro; IPR002100; TF_MADSbox.
DR InterPro; IPR036879; TF_MADSbox_sf.
DR Pfam; PF00319; SRF-TF; 1.
DR PRINTS; PR00404; MADSDOMAIN.
DR SMART; SM00432; MADS; 1.
DR SUPFAM; SSF55455; SSF55455; 1.
DR PROSITE; PS00350; MADS_BOX_1; 1.
DR PROSITE; PS50066; MADS_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN <1..375
FT /note="Serum response factor"
FT /id="PRO_0000199424"
FT DOMAIN 10..64
FT /note="MADS-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 375 AA; 39176 MW; 2ED507978CB20C37 CRC64;
PPPGKKTRGR VKIKMEFIDN KLRRYTTFSK RKTGIMKKAY ELSTLTGTQV LLLVASETGH
VYTFATRKLQ PMITSETGKA LIQTCLNSPD SPPRSDPTTD QRMSATGFEE TDLTYQVSES
DSSGETKDVL KPTFTVTNLP GTTSTIQTAP TTSSSMQVSS GPSFPITNYL APVSASISPS
AVTSANGTVL KTTGASAVTS GGLMQIPTGF TLMSGGTMAQ QVPVQAIQVH QAPQQTSPSS
DSSTDLTQTS PSGTVTLPAT IMTSSVPTTV GGHMMYPSPH AVMYAPTSGL ADGGLAVLNA
FSQTPSAMQV SHSQVQDQGG VPQVFLTAPS GTVQIPVSAV QLHQMAVIGQ QSSSGSSLTE
LQXVNLDTSH NAKSD