ID   SRF_XENLA               Reviewed;         448 AA.
AC   P23790;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Serum response factor;
DE            Short=SRF;
GN   Name=srf;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2009862; DOI=10.1002/j.1460-2075.1991.tb08027.x;
RA   Mohun T.J., Chambers A.E., Towers N., Taylor M.V.;
RT   "Expression of genes encoding the transcription factor SRF during early
RT   development of Xenopus laevis: identification of a CArG box-binding
RT   activity as SRF.";
RL   EMBO J. 10:933-940(1991).
CC   -!- FUNCTION: SRF is a transcription factor that binds to the serum
CC       response element (SRE), a short sequence of dyad symmetry located 300
CC       bp to the 5' of the site of transcription initiation of some genes
CC       (such as FOS). Together with MRTFA transcription coactivator, controls
CC       expression of genes regulating the cytoskeleton during development,
CC       morphogenesis and cell migration. {ECO:0000250|UniProtKB:Q9JM73}.
CC   -!- SUBUNIT: Binds DNA as a multimer, probably a dimer.
CC       {ECO:0000250|UniProtKB:Q9JM73}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9JM73,
CC       ECO:0000255|PROSITE-ProRule:PRU00251}.
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DR   EMBL; X56451; CAA39832.1; -; mRNA.
DR   PIR; S15018; S15018.
DR   RefSeq; NP_001095218.1; NM_001101748.1.
DR   AlphaFoldDB; P23790; -.
DR   SMR; P23790; -.
DR   BioGRID; 98879; 1.
DR   GeneID; 394277; -.
DR   KEGG; xla:394277; -.
DR   CTD; 394277; -.
DR   Xenbase; XB-GENE-864819; srf.L.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 394277; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0010736; F:serum response element binding; ISS:UniProtKB.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0010735; P:positive regulation of transcription via serum response element binding; ISS:UniProtKB.
DR   CDD; cd00266; MADS_SRF_like; 1.
DR   Gene3D; 3.40.1810.10; -; 1.
DR   InterPro; IPR033897; MADS_SRF-like.
DR   InterPro; IPR002100; TF_MADSbox.
DR   InterPro; IPR036879; TF_MADSbox_sf.
DR   Pfam; PF00319; SRF-TF; 1.
DR   PRINTS; PR00404; MADSDOMAIN.
DR   SMART; SM00432; MADS; 1.
DR   SUPFAM; SSF55455; SSF55455; 1.
DR   PROSITE; PS00350; MADS_BOX_1; 1.
DR   PROSITE; PS50066; MADS_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..448
FT                   /note="Serum response factor"
FT                   /id="PRO_0000199425"
FT   DOMAIN          98..152
FT                   /note="MADS-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00251"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   448 AA;  46116 MW;  B3CDCA7E0D97C23B CRC64;
     MLPSNQAGVA GSGRGLGLAR RAGNGAGCPG IRGPGGQYSG SSGSSESGEE EDPPGRGIKR
     GLNELELPEQ GGAAGVVGYP GASGTVSGAK PGKKTRGRVK IKMEFIDNKL RRYTTFSKRK
     TGIMKKAYEL STLTGTQVLL LVASETGHVY TFATRKLQPM ITSETGKALI QTCLNSPDSP
     PRSDPSTDQR MSATGFEETD LTYQVSESDS SGETKDSLKP AFTVTNLPGT SNIQTVPTTS
     TSMQVSSGHS FPITNYLAPV TSANGTVLKT EGGAMSSGGL MQIPAGFTLM SAGGAVAQQV
     PVQAIQVHSA AQASPSSDSS SELVQTSSSG TVTLPAAIMT SSVPTTVSGH MMYPSPHAVM
     YAPTQGLTDG GLAVLNAFSS APQMQVSHTQ EQGGVQQVFL TAPPGTVQIP VSAVQLHQMT
     VIGQQSSGSN LTELQVVNLD TSNSNKND