ID   SRGEF_BOVIN             Reviewed;         464 AA.
AC   Q3MHW0;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Secretion-regulating guanine nucleotide exchange factor;
GN   Name=SERGEF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable guanine nucleotide exchange factor (GEF), which may
CC       be involved in the secretion process. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SEC5. The interaction occurs only in the
CC       presence of magnesium or manganese and is stimulated by dCTP or GTP (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; BC104610; AAI04611.1; -; mRNA.
DR   RefSeq; NP_001069489.1; NM_001076021.1.
DR   AlphaFoldDB; Q3MHW0; -.
DR   SMR; Q3MHW0; -.
DR   STRING; 9913.ENSBTAP00000007022; -.
DR   PaxDb; Q3MHW0; -.
DR   PRIDE; Q3MHW0; -.
DR   Ensembl; ENSBTAT00000007022; ENSBTAP00000007022; ENSBTAG00000005340.
DR   GeneID; 534377; -.
DR   KEGG; bta:534377; -.
DR   CTD; 26297; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005340; -.
DR   VGNC; VGNC:50043; SERGEF.
DR   eggNOG; KOG1426; Eukaryota.
DR   GeneTree; ENSGT00940000160684; -.
DR   HOGENOM; CLU_005210_0_3_1; -.
DR   InParanoid; Q3MHW0; -.
DR   OMA; GYESELC; -.
DR   OrthoDB; 1062377at2759; -.
DR   TreeFam; TF330842; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000005340; Expressed in isthmus of fallopian tube and 107 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0050709; P:negative regulation of protein secretion; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 2.130.10.30; -; 2.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   Pfam; PF00415; RCC1; 3.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   PROSITE; PS00626; RCC1_2; 2.
DR   PROSITE; PS50012; RCC1_3; 7.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..464
FT                   /note="Secretion-regulating guanine nucleotide exchange
FT                   factor"
FT                   /id="PRO_0000259970"
FT   REPEAT          14..66
FT                   /note="RCC1 1"
FT   REPEAT          68..118
FT                   /note="RCC1 2"
FT   REPEAT          119..170
FT                   /note="RCC1 3"
FT   REPEAT          172..229
FT                   /note="RCC1 4"
FT   REPEAT          230..282
FT                   /note="RCC1 5"
FT   REPEAT          283..349
FT                   /note="RCC1 6"
FT   REPEAT          350..401
FT                   /note="RCC1 7"
FT   REGION          301..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        425..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         427
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UGK8"
SQ   SEQUENCE   464 AA;  48955 MW;  F5251C81B905AFA6 CRC64;
     MEPEPHSSEA VPTAAALFAW GANSYGQLGL GHKEDVLSAQ QLSDFCKSGC IKRITGGGGH
     SAVVTDEGSL FVCGLNKDGQ LGLGHTEEVL YFTPCKSLLG CAIQQVACGW DFTIILTENG
     QVLSCGSNSF GQLGVPHGPR RCVIPQAIEL LREKVVSIAA GLRHALAATA SGTVFQWGTG
     LASSGRRLCP GQTLPLFLTA KEPSTVTGLE NSQAVCVLAG SDHSASLTDA GELYVWGSNK
     HGQLASQAAF LLLPQRIEAR CFQNEKIAAV WSGWTHLVAQ TVTGKVFTWG RADYGQLGRT
     VETREGWESE KQDPSLPGSG PQKGTPSCLP CLTGATEISC GSEHNLAVIG GVCHSWGWNE
     HGMCGDGTEA DVWAPKPVPG LRFFLGLHVG CGAGHSLALC QLPALPALGQ HPSVTSPSPD
     ATKEARSQEA MEQERNQKER HAETSPQAQS DRFRNGGLVA ETLE