SRL1_ARATH
ID SRL1_ARATH Reviewed; 393 AA.
AC Q8RWB1; Q9FHS8;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Pre-mRNA splicing factor SR-like 1 {ECO:0000303|PubMed:12047626};
DE Short=AtSRL1 {ECO:0000303|PubMed:12047626};
GN Name=SRL1 {ECO:0000303|PubMed:12047626};
GN OrderedLocusNames=At5g37370 {ECO:0000312|Araport:AT5G37370};
GN ORFNames=MNJ8.19 {ECO:0000312|EMBL:BAB09109.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, PHOSPHORYLATION, AND TISSUE SPECIFICITY.
RX PubMed=12047626; DOI=10.1046/j.1365-313x.2002.01311.x;
RA Forment J., Naranjo M.A., Roldan M., Serrano R., Vicente O.;
RT "Expression of Arabidopsis SR-like splicing proteins confers salt tolerance
RT to yeast and transgenic plants.";
RL Plant J. 30:511-519(2002).
CC -!- FUNCTION: May be required for pre-mRNA splicing (Probable). Confers
CC salt tolerance to LiCl and NaCl (PubMed:12047626).
CC {ECO:0000269|PubMed:12047626, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8RWB1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8RWB1-2; Sequence=VSP_058660;
CC -!- TISSUE SPECIFICITY: Mostly expressed in siliques and leaves, also
CC present in seedlings, flowers and stems, and, at low levels, in roots.
CC {ECO:0000269|PubMed:12047626}.
CC -!- PTM: Phosphorylated. {ECO:0000269|PubMed:12047626}.
CC -!- SIMILARITY: Belongs to the PRP38 family. {ECO:0000305}.
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DR EMBL; AB017069; BAB09109.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94173.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94174.1; -; Genomic_DNA.
DR EMBL; AY093216; AAM13215.1; -; mRNA.
DR EMBL; BT008856; AAP68295.1; -; mRNA.
DR RefSeq; NP_198553.2; NM_123096.3. [Q8RWB1-2]
DR RefSeq; NP_851101.1; NM_180770.2. [Q8RWB1-1]
DR AlphaFoldDB; Q8RWB1; -.
DR SMR; Q8RWB1; -.
DR STRING; 3702.AT5G37370.1; -.
DR iPTMnet; Q8RWB1; -.
DR PaxDb; Q8RWB1; -.
DR PRIDE; Q8RWB1; -.
DR EnsemblPlants; AT5G37370.1; AT5G37370.1; AT5G37370. [Q8RWB1-1]
DR EnsemblPlants; AT5G37370.2; AT5G37370.2; AT5G37370. [Q8RWB1-2]
DR GeneID; 833711; -.
DR Gramene; AT5G37370.1; AT5G37370.1; AT5G37370. [Q8RWB1-1]
DR Gramene; AT5G37370.2; AT5G37370.2; AT5G37370. [Q8RWB1-2]
DR KEGG; ath:AT5G37370; -.
DR Araport; AT5G37370; -.
DR TAIR; locus:2169160; AT5G37370.
DR eggNOG; KOG2888; Eukaryota.
DR HOGENOM; CLU_034151_4_1_1; -.
DR InParanoid; Q8RWB1; -.
DR OMA; ERSHKHD; -.
DR OrthoDB; 1488857at2759; -.
DR PhylomeDB; Q8RWB1; -.
DR PRO; PR:Q8RWB1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8RWB1; baseline and differential.
DR GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0010226; P:response to lithium ion; IMP:UniProtKB.
DR GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR005037; PRP38.
DR InterPro; IPR024767; PRP38_C.
DR PANTHER; PTHR23142; PTHR23142; 1.
DR Pfam; PF03371; PRP38; 1.
DR Pfam; PF12871; PRP38_assoc; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; mRNA processing; mRNA splicing; Nucleus;
KW Phosphoprotein; Reference proteome; Spliceosome.
FT CHAIN 1..393
FT /note="Pre-mRNA splicing factor SR-like 1"
FT /id="PRO_0000438411"
FT REGION 173..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 301..308
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 173..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..315
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..344
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..383
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 141..148
FT /note="Missing (in isoform 2)"
FT /id="VSP_058660"
SQ SEQUENCE 393 AA; 45857 MW; B42AA2C4E7053A2F CRC64;
MAEIQSNGRA YESLLEKVLS MNILSSDYFK ELYGLKTYHE VIDEIYNQVN HVEPWMGGNC
RGPSTAYCLL YKFFTMKLTV KQMHGLLKHT DSPYIRAVGF LYLRYVADAK TLWTWYEPYI
KDDEEFSPGS NGRMTTMGVY VRDLLLGLYY FDTLFPRIPV PVMRQIVSNL EKMNLPTKPS
GSTGDMTRGS EDTARRPPSV KASLSVSFGQ RAPHRASTRG SSPVRRPPPT GYDRNGGDEV
QQRSPRRSQS RDYYSDRDSD RQREREREKD RERERGRDRY RERERDYGND RRSRRDYDSR
SRRNDYEDDR SRHDRRSRSR SRSRSRSVQI EREPTPKRDS SNKEKSAVTV NSNLAKLKDL
YGDASSQKRD EGFGTRKDSS SEEVIKLGGS SWR
