SRLR_ECOLI
ID SRLR_ECOLI Reviewed; 257 AA.
AC P15082; P77030;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Glucitol operon repressor;
GN Name=srlR; Synonyms=gutR; OrderedLocusNames=b2707, JW2676;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3062173; DOI=10.1016/0022-2836(88)90193-3;
RA Yamada M., Saier M.H. Jr.;
RT "Positive and negative regulators for glucitol (gut) operon expression in
RT Escherichia coli.";
RL J. Mol. Biol. 203:569-583(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 1-177.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
CC -!- INTERACTION:
CC P15082; P09373: pflB; NbExp=3; IntAct=EBI-558448, EBI-546682;
CC P15082; P76092: ynbC; NbExp=4; IntAct=EBI-558448, EBI-544837;
CC -!- INDUCTION: By glucitol.
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DR EMBL; J02708; AAC13415.1; -; Genomic_DNA.
DR EMBL; X13463; CAA31820.1; -; Genomic_DNA.
DR EMBL; U29579; AAA69216.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75749.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16568.2; -; Genomic_DNA.
DR PIR; S01832; S01832.
DR RefSeq; NP_417187.1; NC_000913.3.
DR RefSeq; WP_000804550.1; NZ_STEB01000027.1.
DR AlphaFoldDB; P15082; -.
DR SMR; P15082; -.
DR BioGRID; 4263286; 13.
DR BioGRID; 853209; 2.
DR DIP; DIP-10919N; -.
DR IntAct; P15082; 26.
DR STRING; 511145.b2707; -.
DR jPOST; P15082; -.
DR PaxDb; P15082; -.
DR PRIDE; P15082; -.
DR EnsemblBacteria; AAC75749; AAC75749; b2707.
DR EnsemblBacteria; BAA16568; BAA16568; BAA16568.
DR GeneID; 58460128; -.
DR GeneID; 948942; -.
DR KEGG; ecj:JW2676; -.
DR KEGG; eco:b2707; -.
DR PATRIC; fig|1411691.4.peg.4035; -.
DR EchoBASE; EB0967; -.
DR eggNOG; COG1349; Bacteria.
DR HOGENOM; CLU_060699_0_1_6; -.
DR InParanoid; P15082; -.
DR OMA; KHGQEHF; -.
DR PhylomeDB; P15082; -.
DR BioCyc; EcoCyc:PD00283; -.
DR PRO; PR:P15082; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:EcoCyc.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR014036; DeoR_C.
DR InterPro; IPR001034; DeoR_HTH.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00455; DeoRC; 1.
DR Pfam; PF08220; HTH_DeoR; 1.
DR SMART; SM00420; HTH_DEOR; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00894; HTH_DEOR_1; 1.
DR PROSITE; PS51000; HTH_DEOR_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Phosphotransferase system; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..257
FT /note="Glucitol operon repressor"
FT /id="PRO_0000050268"
FT DOMAIN 3..58
FT /note="HTH deoR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT DNA_BIND 20..39
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ SEQUENCE 257 AA; 28236 MW; BAEAB73A51DD27A0 CRC64;
MKPRQRQAAI LEYLQKQGKC SVEELAQYFD TTGTTIRKDL VILEHAGTVI RTYGGVVLNK
EESDPPIDHK TLINTHKKEL IAEAAVSFIH DGDSIILDAG STVLQMVPLL SRFNNITVMT
NSLHIVNALS ELDNEQTILM PGGTFRKKSA SFHGQLAENA FEHFTFDKLF MGTDGIDLNA
GVTTFNEVYT VSKAMCNAAR EVILMADSSK FGRKSPNVVC SLESVDKLIT DAGIDPAFRQ
ALEEKGIDVI ITGESNE
