ID   SRO1_SCHPO              Reviewed;         106 AA.
AC   O94629;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Stress-responsive protein 1;
GN   Name=sro1; ORFNames=SPBC1347.11;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   INDUCTION, FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18410345; DOI=10.1111/j.1567-1364.2008.00373.x;
RA   Sundaram G., Palchaudhuri S., Chaudhuri S., Karunanithi S.,
RA   Chattopadhyay D.;
RT   "Characterization of Sro1, a novel stress responsive protein in
RT   Schizosaccharomyces pombe.";
RL   FEMS Yeast Res. 8:564-573(2008).
CC   -!- FUNCTION: Stress-responsive protein that may play a role in regulation
CC       of cell cycle. {ECO:0000269|PubMed:18410345}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16823372,
CC       ECO:0000269|PubMed:18410345}.
CC   -!- INDUCTION: Expression is up-regulated by heat and in response to
CC       hydroxyurea. This regulation is under the control of the protein
CC       kinases sty1 and rad3. {ECO:0000269|PubMed:18410345}.
CC   -!- DISRUPTION PHENOTYPE: Leads to reduced growth rate and altered ROS
CC       generation during stress conditions like heat or treatment by
CC       hydroxyurea. {ECO:0000269|PubMed:18410345}.
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DR   EMBL; CU329671; CAB37442.1; -; Genomic_DNA.
DR   PIR; T39399; T39399.
DR   RefSeq; NP_596703.1; NM_001022627.2.
DR   AlphaFoldDB; O94629; -.
DR   BioGRID; 276673; 6.
DR   STRING; 4896.SPBC1347.11.1; -.
DR   MaxQB; O94629; -.
DR   PaxDb; O94629; -.
DR   EnsemblFungi; SPBC1347.11.1; SPBC1347.11.1:pep; SPBC1347.11.
DR   GeneID; 2540136; -.
DR   KEGG; spo:SPBC1347.11; -.
DR   PomBase; SPBC1347.11; sro1.
DR   VEuPathDB; FungiDB:SPBC1347.11; -.
DR   HOGENOM; CLU_2224744_0_0_1; -.
DR   PRO; PR:O94629; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005739; C:mitochondrion; IDA:PomBase.
DR   GO; GO:0045454; P:cell redox homeostasis; IMP:PomBase.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IMP:PomBase.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Stress response.
FT   CHAIN           1..106
FT                   /note="Stress-responsive protein 1"
FT                   /id="PRO_0000116756"
SQ   SEQUENCE   106 AA;  11463 MW;  7DEBA2E7E56B72B1 CRC64;
     MFSILKQGVI SKSLLAATSL KATASRFSFS TSVASRVDGT KNGWSFTASN VADQTTDIGI
     NSESAMSCND QEQPLSFYVQ TVRDDLNSPN WGAEQRKGAF DWEVSA