ID   SRP09_CANLF             Reviewed;          86 AA.
AC   P21262;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Signal recognition particle 9 kDa protein;
DE            Short=SRP9;
GN   Name=SRP9;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-32.
RX   PubMed=2153922; DOI=10.1128/mcb.10.2.777-784.1990;
RA   Strub K., Walter P.;
RT   "Assembly of the Alu domain of the signal recognition particle (SRP):
RT   dimerization of the two protein components is required for efficient
RT   binding to SRP RNA.";
RL   Mol. Cell. Biol. 10:777-784(1990).
RN   [2]
RP   FUNCTION, AND IDENTIFICATION IN A SIGNAL RECOGNITION PARTICLE COMPLEX.
RX   PubMed=6938958; DOI=10.1073/pnas.77.12.7112;
RA   Walter P., Blobel G.;
RT   "Purification of a membrane-associated protein complex required for protein
RT   translocation across the endoplasmic reticulum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 77:7112-7116(1980).
RN   [3]
RP   FUNCTION, RNA BINDING, AND SUBUNIT.
RX   PubMed=6413076; DOI=10.1016/0092-8674(83)90385-9;
RA   Walter P., Blobel G.;
RT   "Disassembly and reconstitution of signal recognition particle.";
RL   Cell 34:525-533(1983).
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC       ribonucleoprotein complex that mediates the cotranslational targeting
CC       of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC       (PubMed:6938958, PubMed:6413076). SRP9 together with SRP14 and the Alu
CC       portion of the SRP RNA, constitutes the elongation arrest domain of SRP
CC       (PubMed:6938958, PubMed:6413076). The complex of SRP9 and SRP14 is
CC       required for SRP RNA binding (PubMed:6938958, PubMed:6413076).
CC       {ECO:0000269|PubMed:6413076, ECO:0000269|PubMed:6938958}.
CC   -!- SUBUNIT: Heterodimer with SRP14; binds RNA as heterodimer
CC       (PubMed:6413076). Component of a signal recognition particle complex
CC       that consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC       subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (PubMed:6938958,
CC       PubMed:6413076). {ECO:0000269|PubMed:6413076,
CC       ECO:0000269|PubMed:6938958}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the SRP9 family. {ECO:0000305}.
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DR   EMBL; M34952; AAA30897.1; -; mRNA.
DR   PIR; A34731; A34731.
DR   PDB; 4UE5; EM; 9.00 A; E=2-75.
DR   PDB; 6FRK; EM; 3.70 A; w=2-75.
DR   PDB; 7OBR; EM; 2.80 A; w=1-86.
DR   PDBsum; 4UE5; -.
DR   PDBsum; 6FRK; -.
DR   PDBsum; 7OBR; -.
DR   AlphaFoldDB; P21262; -.
DR   SMR; P21262; -.
DR   STRING; 9615.ENSCAFP00000023824; -.
DR   PaxDb; P21262; -.
DR   eggNOG; KOG3465; Eukaryota.
DR   InParanoid; P21262; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0045900; P:negative regulation of translational elongation; IEA:InterPro.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.720.10; -; 1.
DR   InterPro; IPR008832; Signal_recog_particle_SRP9.
DR   InterPro; IPR009018; Signal_recog_particle_SRP9/14.
DR   InterPro; IPR039914; SRP9.
DR   InterPro; IPR039432; SRP9_dom.
DR   PANTHER; PTHR12834; PTHR12834; 1.
DR   Pfam; PF05486; SRP9-21; 1.
DR   PIRSF; PIRSF017029; Signal_recog_particle_SRP9; 1.
DR   SUPFAM; SSF54762; SSF54762; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Direct protein sequencing; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Signal recognition particle.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:2153922"
FT   CHAIN           2..86
FT                   /note="Signal recognition particle 9 kDa protein"
FT                   /id="PRO_0000135181"
SQ   SEQUENCE   86 AA;  10046 MW;  60E3E1E8B20E7BD1 CRC64;
     MAQYQTWEEF SRAAEKLYLA DPMKARVVLK YRHSDGSLCI KVTDDLVCLV YRTDQAQDVK
     KIEKFHSQLM RLMVAKESRS VAMETD