SRP09_DROME
ID SRP09_DROME Reviewed; 77 AA.
AC Q9VSC1;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Signal recognition particle 9 kDa protein;
DE Short=SRP9;
GN Name=Srp9; ORFNames=CG8268;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=15901661; DOI=10.1242/dev.01863;
RA Abrams E.W., Andrew D.J.;
RT "CrebA regulates secretory activity in the Drosophila salivary gland and
RT epidermis.";
RL Development 132:2743-2758(2005).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). SRP9 together with Srp14 and the Alu portion of the
CC SRP RNA, constitutes the elongation arrest domain of SRP (By
CC similarity). The complex of Srp9 and Srp14 is required for SRP RNA
CC binding (By similarity). {ECO:0000250|UniProtKB:P21262}.
CC -!- SUBUNIT: Heterodimer with Srp14; binds RNA as heterodimer (By
CC similarity). Component of a signal recognition particle complex that
CC consists of a 7SL RNA molecule and six protein subunits: Srp72, Srp68,
CC Srp54, Srp19, Srp14 and Srp9 (By similarity).
CC {ECO:0000250|UniProtKB:P21262, ECO:0000250|UniProtKB:P49458}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SRP9 family. {ECO:0000305}.
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DR EMBL; AE014296; AAF50504.1; -; Genomic_DNA.
DR EMBL; AY071180; AAL48802.1; -; mRNA.
DR RefSeq; NP_648163.1; NM_139906.3.
DR AlphaFoldDB; Q9VSC1; -.
DR SMR; Q9VSC1; -.
DR BioGRID; 64309; 5.
DR DIP; DIP-18881N; -.
DR IntAct; Q9VSC1; 3.
DR STRING; 7227.FBpp0076467; -.
DR PaxDb; Q9VSC1; -.
DR PRIDE; Q9VSC1; -.
DR DNASU; 38883; -.
DR EnsemblMetazoa; FBtr0076750; FBpp0076467; FBgn0035827.
DR GeneID; 38883; -.
DR KEGG; dme:Dmel_CG8268; -.
DR UCSC; CG8268-RA; d. melanogaster.
DR CTD; 6726; -.
DR FlyBase; FBgn0035827; Srp9.
DR VEuPathDB; VectorBase:FBgn0035827; -.
DR eggNOG; KOG3465; Eukaryota.
DR GeneTree; ENSGT00390000018505; -.
DR HOGENOM; CLU_144337_3_0_1; -.
DR InParanoid; Q9VSC1; -.
DR OMA; YINSWEE; -.
DR OrthoDB; 1623953at2759; -.
DR PhylomeDB; Q9VSC1; -.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR BioGRID-ORCS; 38883; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38883; -.
DR PRO; PR:Q9VSC1; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0035827; Expressed in saliva-secreting gland and 33 other tissues.
DR Genevisible; Q9VSC1; DM.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0045900; P:negative regulation of translational elongation; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IBA:GO_Central.
DR Gene3D; 3.30.720.10; -; 1.
DR InterPro; IPR008832; Signal_recog_particle_SRP9.
DR InterPro; IPR009018; Signal_recog_particle_SRP9/14.
DR InterPro; IPR039914; SRP9.
DR InterPro; IPR039432; SRP9_dom.
DR PANTHER; PTHR12834; PTHR12834; 1.
DR Pfam; PF05486; SRP9-21; 1.
DR PIRSF; PIRSF017029; Signal_recog_particle_SRP9; 1.
DR SUPFAM; SSF54762; SSF54762; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW Signal recognition particle.
FT CHAIN 1..77
FT /note="Signal recognition particle 9 kDa protein"
FT /id="PRO_0000135185"
SQ SEQUENCE 77 AA; 8974 MW; 9743581E6C78D0A0 CRC64;
MVFVKNWDDF EIAVENMYLA NPQNCRLTMK YAHSKGHILL KMTDNVKCVQ YKAENMPDLR
KIEKITSNLV GHMASKE
