ID   SRP14_CAEEL             Reviewed;         116 AA.
AC   O16927;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Signal recognition particle 14 kDa protein;
DE            Short=SRP14;
GN   ORFNames=F25G6.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC       ribonucleoprotein complex that mediates the cotranslational targeting
CC       of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC       (By similarity). F37F2.2/srpa-19 together with F25G6.8/srpa-14 and the
CC       Alu portion of the SRP RNA, constitutes the elongation arrest domain of
CC       SRP (By similarity). The complex of F37F2.2/srpa-19 and F25G6.8/srpa-14
CC       is required for SRP RNA binding (By similarity).
CC       {ECO:0000250|UniProtKB:P37108}.
CC   -!- SUBUNIT: Heterodimer with ZK512.4/SRP9; binds RNA as heterodimer (By
CC       similarity). Component of a signal recognition particle (SRP) complex
CC       that consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC       subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and
CC       ZK512.4/SRP9 (By similarity). {ECO:0000250|UniProtKB:P16255,
CC       ECO:0000250|UniProtKB:P37108}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the SRP14 family. {ECO:0000305}.
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DR   EMBL; FO080489; CCD64109.1; -; Genomic_DNA.
DR   PIR; G89134; G89134.
DR   RefSeq; NP_505208.1; NM_072807.4.
DR   AlphaFoldDB; O16927; -.
DR   SMR; O16927; -.
DR   BioGRID; 44276; 2.
DR   DIP; DIP-26264N; -.
DR   STRING; 6239.F25G6.8; -.
DR   EPD; O16927; -.
DR   PaxDb; O16927; -.
DR   PeptideAtlas; O16927; -.
DR   EnsemblMetazoa; F25G6.8.1; F25G6.8.1; WBGene00017799.
DR   GeneID; 179236; -.
DR   KEGG; cel:CELE_F25G6.8; -.
DR   UCSC; F25G6.8.2; c. elegans.
DR   CTD; 179236; -.
DR   WormBase; F25G6.8; CE09644; WBGene00017799; -.
DR   eggNOG; KOG1761; Eukaryota.
DR   GeneTree; ENSGT00390000008496; -.
DR   HOGENOM; CLU_094309_2_1_1; -.
DR   InParanoid; O16927; -.
DR   OMA; EQHIPND; -.
DR   OrthoDB; 1634105at2759; -.
DR   PhylomeDB; O16927; -.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   PRO; PR:O16927; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00017799; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
DR   GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.720.10; -; 1.
DR   InterPro; IPR003210; Signal_recog_particle_SRP14.
DR   InterPro; IPR009018; Signal_recog_particle_SRP9/14.
DR   PANTHER; PTHR12013; PTHR12013; 1.
DR   Pfam; PF02290; SRP14; 1.
DR   SUPFAM; SSF54762; SSF54762; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..116
FT                   /note="Signal recognition particle 14 kDa protein"
FT                   /id="PRO_0000135192"
SQ   SEQUENCE   116 AA;  13203 MW;  AE7CFC850A1AA4C5 CRC64;
     MSAVEQHIPN DQFLQKLTAF YRDSKIRGPK SVYVTMKPYD GRTKAMPKGS TFKEGDEISC
     IFRAKWGSKK IATEVKAKEV NKFHTQYSAI IVAQMVNLEK RKKTDDEKKK TGATKA