SRP14_DICDI
ID SRP14_DICDI Reviewed; 123 AA.
AC Q556L1; Q86AM4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Signal recognition particle 14 kDa protein;
DE Short=SRP14;
GN Name=srp14-1; ORFNames=DDB_G0272590;
GN and
GN Name=srp14-2; ORFNames=DDB_G0273977;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). Srp9 together with srp14 and the Alu portion of the
CC SRP RNA, constitutes the elongation arrest domain of SRP (By
CC similarity). The complex of srp9 and srp14 is required for SRP RNA
CC binding (By similarity). {ECO:0000250|UniProtKB:P37108}.
CC -!- SUBUNIT: Heterodimer with srp9; binds RNA as heterodimer (By
CC similarity). Component of a signal recognition particle (SRP) complex
CC that consists of a 7SL RNA molecule and six protein subunits: srp72,
CC srp68, srp54, srp19, srp14 and srp9 (By similarity).
CC {ECO:0000250|UniProtKB:P16255, ECO:0000250|UniProtKB:P37108}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SRP14 family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70422.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70932.1; -; Genomic_DNA.
DR RefSeq; XP_644347.1; XM_639255.1.
DR RefSeq; XP_645067.1; XM_639975.1.
DR AlphaFoldDB; Q556L1; -.
DR SMR; Q556L1; -.
DR STRING; 44689.DDB0232380; -.
DR PaxDb; Q556L1; -.
DR EnsemblProtists; EAL70422; EAL70422; DDB_G0273977.
DR EnsemblProtists; EAL70932; EAL70932; DDB_G0272590.
DR GeneID; 8618742; -.
DR GeneID; 8619234; -.
DR KEGG; ddi:DDB_G0272590; -.
DR KEGG; ddi:DDB_G0273977; -.
DR dictyBase; DDB_G0272590; srp14-1.
DR dictyBase; DDB_G0273977; srp14-2.
DR eggNOG; KOG1761; Eukaryota.
DR HOGENOM; CLU_094309_2_1_1; -.
DR InParanoid; Q556L1; -.
DR OMA; KEVTHFS; -.
DR PhylomeDB; Q556L1; -.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR PRO; PR:Q556L1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
DR GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR Gene3D; 3.30.720.10; -; 1.
DR InterPro; IPR003210; Signal_recog_particle_SRP14.
DR InterPro; IPR009018; Signal_recog_particle_SRP9/14.
DR PANTHER; PTHR12013; PTHR12013; 1.
DR Pfam; PF02290; SRP14; 1.
DR SUPFAM; SSF54762; SSF54762; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW Signal recognition particle.
FT CHAIN 1..123
FT /note="Signal recognition particle 14 kDa protein"
FT /id="PRO_0000312430"
FT REGION 99..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 123 AA; 13893 MW; 6EE3F5E0BACE80C1 CRC64;
MLLDNDAFLS ALNKLYQTTS KKGTVWVTMK KYVDSDSNFS RKKAERIKES EEEENKCLVR
ATNGKKKIST IVLAKDKSMF EKNYKNVLLI NLDNLKVEKK KPTPTTTPSS STTAKTAAKK
TKV
