ID   SRP14_MACFA             Reviewed;         144 AA.
AC   Q4R5C7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Signal recognition particle 14 kDa protein;
DE            Short=SRP14;
GN   Name=SRP14; ORFNames=QtrA-11111;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC       ribonucleoprotein complex that mediates the cotranslational targeting
CC       of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC       (By similarity). SRP9 together with SRP14 and the Alu portion of the
CC       SRP RNA, constitutes the elongation arrest domain of SRP (By
CC       similarity). The complex of SRP9 and SRP14 is required for SRP RNA
CC       binding (By similarity). {ECO:0000250|UniProtKB:P37108}.
CC   -!- SUBUNIT: Heterodimer with SRP9; binds RNA as heterodimer (By
CC       similarity). Component of a signal recognition particle (SRP) complex
CC       that consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC       subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).
CC       {ECO:0000250|UniProtKB:P16255, ECO:0000250|UniProtKB:P37108}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SRP14 family. {ECO:0000305}.
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DR   EMBL; AB169617; BAE01698.1; -; mRNA.
DR   RefSeq; NP_001272066.1; NM_001285137.1.
DR   AlphaFoldDB; Q4R5C7; -.
DR   SMR; Q4R5C7; -.
DR   STRING; 9541.XP_005559207.1; -.
DR   GeneID; 101864926; -.
DR   CTD; 6727; -.
DR   eggNOG; KOG1761; Eukaryota.
DR   OrthoDB; 1634105at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR   GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.720.10; -; 1.
DR   InterPro; IPR003210; Signal_recog_particle_SRP14.
DR   InterPro; IPR009018; Signal_recog_particle_SRP9/14.
DR   PANTHER; PTHR12013; PTHR12013; 1.
DR   Pfam; PF02290; SRP14; 1.
DR   SUPFAM; SSF54762; SSF54762; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   RNA-binding; Signal recognition particle.
FT   CHAIN           1..144
FT                   /note="Signal recognition particle 14 kDa protein"
FT                   /id="PRO_0000322236"
FT   MOD_RES         27
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P37108"
SQ   SEQUENCE   144 AA;  15193 MW;  76B11F2DDDF9382D CRC64;
     MVLLESEQFL TELTRLFQKC RTSGSVYITL KKYDGRTKPI PKKGTVEGFE PADNKCLLRA
     TDGKKKISTV VSSKEVNKFQ MAYSNLLRAN MDGLKKRDKK NKTKKTKAAA AAAAAAVAAA
     AAPAAAATTA TPATPAATAA TAAQ