SRP14_SCHPO
ID SRP14_SCHPO Reviewed; 106 AA.
AC Q9P372;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Signal recognition particle subunit srp14;
DE AltName: Full=Signal recognition particle 14 kDa protein homolog;
GN Name=srp14; ORFNames=SPAC19B12.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER).
CC {ECO:0000250|UniProtKB:P38985}.
CC -!- SUBUNIT: Component of a fungal signal recognition particle (SRP)
CC complex that consists of a 7SL RNA molecule (scR1) and at least six
CC protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.
CC {ECO:0000250|UniProtKB:P38985}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SRP14 family. {ECO:0000305}.
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DR EMBL; CU329670; CAC00557.1; -; Genomic_DNA.
DR RefSeq; NP_594772.1; NM_001020199.2.
DR PDB; 2W9J; X-ray; 2.60 A; A/B=1-91.
DR PDBsum; 2W9J; -.
DR AlphaFoldDB; Q9P372; -.
DR SMR; Q9P372; -.
DR BioGRID; 279021; 1.
DR STRING; 4896.SPAC19B12.09.1; -.
DR MaxQB; Q9P372; -.
DR PaxDb; Q9P372; -.
DR PRIDE; Q9P372; -.
DR EnsemblFungi; SPAC19B12.09.1; SPAC19B12.09.1:pep; SPAC19B12.09.
DR GeneID; 2542565; -.
DR KEGG; spo:SPAC19B12.09; -.
DR PomBase; SPAC19B12.09; srp14.
DR VEuPathDB; FungiDB:SPAC19B12.09; -.
DR eggNOG; KOG1761; Eukaryota.
DR HOGENOM; CLU_094309_1_0_1; -.
DR InParanoid; Q9P372; -.
DR OMA; IFLTQKR; -.
DR PhylomeDB; Q9P372; -.
DR BRENDA; 3.6.5.4; 5613.
DR Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SPO-6798695; Neutrophil degranulation.
DR EvolutionaryTrace; Q9P372; -.
DR PRO; PR:Q9P372; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; ISO:PomBase.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IC:PomBase.
DR GO; GO:0045047; P:protein targeting to ER; IBA:GO_Central.
DR GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; ISO:PomBase.
DR Gene3D; 3.30.720.10; -; 1.
DR InterPro; IPR003210; Signal_recog_particle_SRP14.
DR InterPro; IPR009018; Signal_recog_particle_SRP9/14.
DR PANTHER; PTHR12013; PTHR12013; 1.
DR Pfam; PF02290; SRP14; 1.
DR SUPFAM; SSF54762; SSF54762; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW RNA-binding; Signal recognition particle.
FT CHAIN 1..106
FT /note="Signal recognition particle subunit srp14"
FT /id="PRO_0000135195"
FT REGION 86..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 5..17
FT /evidence="ECO:0007829|PDB:2W9J"
FT STRAND 30..36
FT /evidence="ECO:0007829|PDB:2W9J"
FT STRAND 45..51
FT /evidence="ECO:0007829|PDB:2W9J"
FT STRAND 57..63
FT /evidence="ECO:0007829|PDB:2W9J"
FT HELIX 64..66
FT /evidence="ECO:0007829|PDB:2W9J"
FT HELIX 67..82
FT /evidence="ECO:0007829|PDB:2W9J"
SQ SEQUENCE 106 AA; 11718 MW; B8E00A3CEFF71B2E CRC64;
MLLSNEEFLK KLTDLLQTHQ SKGTGSVYLS QKCNPVDEGE GSSASVLIRA KSGAAEKIST
VVELDYFTDF FQSYAEVCKG QIVGLKKRDR KKTKKNKKKT TSSGHT
