ABHDB_MOUSE
ID ABHDB_MOUSE Reviewed; 307 AA.
AC Q8K4F5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein ABHD11 {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 11 {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 11 {ECO:0000312|MGI:MGI:1916008};
DE AltName: Full=Williams-Beuren syndrome chromosomal region 21 protein homolog;
GN Name=Abhd11 {ECO:0000312|MGI:MGI:1916008}; Synonyms=Wbscr21;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12073013; DOI=10.1007/s00439-002-0710-x;
RA Merla G., Ucla C., Guipponi M., Reymond A.;
RT "Identification of additional transcripts in the Williams-Beuren syndrome
RT critical region.";
RL Hum. Genet. 110:429-438(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17215164; DOI=10.1016/j.bbalip.2006.11.009;
RA Shen W.-J., Patel S., Yu Z., Jue D., Kraemer F.B.;
RT "Effects of rosiglitazone and high fat diet on lipase/esterase expression
RT in adipose tissue.";
RL Biochim. Biophys. Acta 1771:177-184(2007).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-79 AND LYS-196, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- TISSUE SPECIFICITY: Expressed in white adipose tissues.
CC {ECO:0000269|PubMed:17215164}.
CC -!- INDUCTION: Up-regulated by rosiglitazone and down-regulated by high fat
CC feeding. {ECO:0000269|PubMed:17215164}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF412033; AAM62315.1; -; mRNA.
DR EMBL; BC069866; AAH69866.1; -; mRNA.
DR CCDS; CCDS19730.1; -.
DR RefSeq; NP_660250.1; NM_145215.2.
DR AlphaFoldDB; Q8K4F5; -.
DR SMR; Q8K4F5; -.
DR STRING; 10090.ENSMUSP00000043041; -.
DR ChEMBL; CHEMBL1795090; -.
DR ESTHER; mouse-Abhd11; ABHD11-Acetyl_transferase.
DR iPTMnet; Q8K4F5; -.
DR PhosphoSitePlus; Q8K4F5; -.
DR EPD; Q8K4F5; -.
DR jPOST; Q8K4F5; -.
DR MaxQB; Q8K4F5; -.
DR PaxDb; Q8K4F5; -.
DR PeptideAtlas; Q8K4F5; -.
DR PRIDE; Q8K4F5; -.
DR ProteomicsDB; 296437; -.
DR Antibodypedia; 14446; 136 antibodies from 24 providers.
DR DNASU; 68758; -.
DR Ensembl; ENSMUST00000046999; ENSMUSP00000043041; ENSMUSG00000040532.
DR GeneID; 68758; -.
DR KEGG; mmu:68758; -.
DR UCSC; uc008zxg.2; mouse.
DR CTD; 83451; -.
DR MGI; MGI:1916008; Abhd11.
DR VEuPathDB; HostDB:ENSMUSG00000040532; -.
DR eggNOG; KOG2382; Eukaryota.
DR GeneTree; ENSGT00390000015880; -.
DR HOGENOM; CLU_020336_53_0_1; -.
DR InParanoid; Q8K4F5; -.
DR OMA; MMYFARK; -.
DR OrthoDB; 1268438at2759; -.
DR PhylomeDB; Q8K4F5; -.
DR TreeFam; TF314071; -.
DR BioGRID-ORCS; 68758; 5 hits in 71 CRISPR screens.
DR ChiTaRS; Abhd11; mouse.
DR PRO; PR:Q8K4F5; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8K4F5; protein.
DR Bgee; ENSMUSG00000040532; Expressed in interventricular septum and 239 other tissues.
DR ExpressionAtlas; Q8K4F5; baseline and differential.
DR Genevisible; Q8K4F5; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IBA:GO_Central.
DR GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..307
FT /note="Protein ABHD11"
FT /id="PRO_0000281004"
FT ACT_SITE 133
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 229
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 288
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT MOD_RES 79
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 196
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
SQ SEQUENCE 307 AA; 33561 MW; B1FAB20B83545B77 CRC64;
MLRWARAWRV PRGVLGASSP RRLAVPVTFC SSRSSGQENA DLRPLPLSYN LLDGDATLPA
IVFLHGLFGS KTNFNSLAKA MVQRTGRRVL TVDARNHGDS PHSPDASYEA MSQDLQGLLP
QLGLVPCVLV GHSMGGKTAM LLALQRPDVV ERLVVVDISP VGTTPGSHIG AFIAAMKAVE
IPEKVPHSQA RKLADKQLSS VVKEAGIRQF LLTNLVEVGG RFSWRLNLDT LAQHLDKIMT
FPQQREPYSG PTLFLLGGNS TYVQPSHHSE IRRLFPQAQI QTVPNAGHWV HSDKPQDFMD
AVTSFLA
