SRP19_ARATH
ID SRP19_ARATH Reviewed; 145 AA.
AC Q943Z6; Q9LNG9;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Signal recognition particle 19 kDa protein;
DE Short=SRP19;
GN Name=SRP19; OrderedLocusNames=At1g48160; ORFNames=F21D18.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). Binds directly to 7SL RNA (By similarity). Mediates
CC binding of SRP54 to the SRP complex (By similarity).
CC {ECO:0000250|UniProtKB:J9PAS6}.
CC -!- SUBUNIT: Component of a signal recognition particle complex that
CC consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
CC {ECO:0000250|UniProtKB:P09132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09132}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P09132}.
CC -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79519.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC023673; AAF79519.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32257.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60896.1; -; Genomic_DNA.
DR EMBL; AF439847; AAL27515.1; -; mRNA.
DR EMBL; AY125568; AAM78078.1; -; mRNA.
DR EMBL; AY088346; AAM65885.1; -; mRNA.
DR RefSeq; NP_001323146.1; NM_001333300.1.
DR RefSeq; NP_175250.1; NM_103712.3.
DR AlphaFoldDB; Q943Z6; -.
DR SMR; Q943Z6; -.
DR STRING; 3702.AT1G48160.1; -.
DR iPTMnet; Q943Z6; -.
DR PaxDb; Q943Z6; -.
DR PRIDE; Q943Z6; -.
DR ProteomicsDB; 226878; -.
DR EnsemblPlants; AT1G48160.1; AT1G48160.1; AT1G48160.
DR EnsemblPlants; AT1G48160.2; AT1G48160.2; AT1G48160.
DR GeneID; 841235; -.
DR Gramene; AT1G48160.1; AT1G48160.1; AT1G48160.
DR Gramene; AT1G48160.2; AT1G48160.2; AT1G48160.
DR KEGG; ath:AT1G48160; -.
DR Araport; AT1G48160; -.
DR TAIR; locus:2020895; AT1G48160.
DR eggNOG; KOG3198; Eukaryota.
DR HOGENOM; CLU_064201_1_0_1; -.
DR InParanoid; Q943Z6; -.
DR OMA; CVENPTH; -.
DR OrthoDB; 1552706at2759; -.
DR PhylomeDB; Q943Z6; -.
DR PRO; PR:Q943Z6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q943Z6; baseline and differential.
DR Genevisible; Q943Z6; AT.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR Gene3D; 3.30.56.30; -; 1.
DR InterPro; IPR002778; Signal_recog_particle_SRP19.
DR InterPro; IPR036521; SRP19-like_sf.
DR PANTHER; PTHR17453; PTHR17453; 1.
DR Pfam; PF01922; SRP19; 1.
DR SUPFAM; SSF69695; SSF69695; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein;
KW RNA-binding; Signal recognition particle.
FT CHAIN 1..145
FT /note="Signal recognition particle 19 kDa protein"
FT /id="PRO_0000135202"
FT REGION 104..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22223895"
SQ SEQUENCE 145 AA; 16274 MW; EF1AE064DE08F6B1 CRC64;
MDSGTINIKK WVVIYPVYIN SKKTVAEGRR ISVSKSCENP NCIEISDCCK HLKLPSAVEI
DKAYPRDFMQ VGRVRVQLKR EDGTLLNPAI TSRKHLMQKI AELVPRHPER VKKQEAQKAK
KQEPQATTST SGTSSKSGKG GKKKR
