ID   SRP19_BOVIN             Reviewed;         144 AA.
AC   Q3ZBG7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Signal recognition particle 19 kDa protein;
DE            Short=SRP19;
GN   Name=SRP19;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC       ribonucleoprotein complex that mediates the cotranslational targeting
CC       of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC       (By similarity). Binds directly to 7SL RNA (By similarity). Mediates
CC       binding of SRP54 to the SRP complex (By similarity).
CC       {ECO:0000250|UniProtKB:J9PAS6}.
CC   -!- SUBUNIT: Component of a signal recognition particle complex that
CC       consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC       subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with
CC       IPO5, IPO7, IPO8, KPNB1 and TNPO1. Interactions with IPO8 and TNPO1 may
CC       be involved in SRP19 import into the nucleus (By similarity).
CC       {ECO:0000250|UniProtKB:P09132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09132}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:P09132}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:P09132}. Note=Although the signal recognition
CC       particle complex acts in the cytoplasm, it assembles at least in part
CC       in the nucleus and/or the nucleolus. SRP19 nuclear import may be
CC       mediated by IPO8/Imp8 and TPNO1/Trn. {ECO:0000250|UniProtKB:P09132}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; BC103304; AAI03305.1; -; mRNA.
DR   RefSeq; NP_001029650.1; NM_001034478.1.
DR   AlphaFoldDB; Q3ZBG7; -.
DR   SMR; Q3ZBG7; -.
DR   STRING; 9913.ENSBTAP00000017007; -.
DR   PaxDb; Q3ZBG7; -.
DR   PRIDE; Q3ZBG7; -.
DR   Ensembl; ENSBTAT00000017007; ENSBTAP00000017007; ENSBTAG00000012803.
DR   GeneID; 514960; -.
DR   KEGG; bta:514960; -.
DR   CTD; 6728; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012803; -.
DR   VGNC; VGNC:55145; SRP19.
DR   eggNOG; KOG3198; Eukaryota.
DR   GeneTree; ENSGT00390000004950; -.
DR   HOGENOM; CLU_064201_2_1_1; -.
DR   InParanoid; Q3ZBG7; -.
DR   OMA; CVENPTH; -.
DR   OrthoDB; 1552706at2759; -.
DR   TreeFam; TF106248; -.
DR   Reactome; R-BTA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000012803; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR   GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IEA:Ensembl.
DR   GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..144
FT                   /note="Signal recognition particle 19 kDa protein"
FT                   /id="PRO_0000247642"
FT   REGION          117..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..134
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  16140 MW;  52CD752FAFC75EA8 CRC64;
     MACAAARSPA DQDRFICIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCAAVGLNV
     FLEKNKMYSR EWNRDLQYRG RVRVQLKQED GSLCLVQFPS RKSVMLYAAE MIPKLKTRTQ
     KTGGGDQSLQ QGEGSKKGKG KKKK