SRP19_CAEEL
ID SRP19_CAEEL Reviewed; 142 AA.
AC O61749;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2013, sequence version 4.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Probable signal recognition particle 19 kDa protein;
DE Short=SRP19;
GN ORFNames=F37F2.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). Binds directly to 7SL RNA (By similarity). Mediates
CC binding of SRP54 to the SRP complex (By similarity).
CC {ECO:0000250|UniProtKB:J9PAS6}.
CC -!- SUBUNIT: Component of a signal recognition particle complex that
CC consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and
CC ZK512.4/SRP9. {ECO:0000250|UniProtKB:P09132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09132}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P09132}.
CC -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR EMBL; FO081321; CCD70777.2; -; Genomic_DNA.
DR PIR; T33052; T33052.
DR RefSeq; NP_490855.3; NM_058454.3.
DR AlphaFoldDB; O61749; -.
DR SMR; O61749; -.
DR BioGRID; 37206; 2.
DR STRING; 6239.F37F2.2.2; -.
DR EPD; O61749; -.
DR PaxDb; O61749; -.
DR PeptideAtlas; O61749; -.
DR EnsemblMetazoa; F37F2.2.1; F37F2.2.1; WBGene00018159.
DR EnsemblMetazoa; F37F2.2.2; F37F2.2.2; WBGene00018159.
DR GeneID; 171711; -.
DR KEGG; cel:CELE_F37F2.2; -.
DR UCSC; F37F2.2; c. elegans.
DR CTD; 171711; -.
DR WormBase; F37F2.2; CE47742; WBGene00018159; -.
DR eggNOG; KOG3198; Eukaryota.
DR GeneTree; ENSGT00390000004950; -.
DR HOGENOM; CLU_064201_2_1_1; -.
DR InParanoid; O61749; -.
DR OMA; QKRWIVI; -.
DR OrthoDB; 1552706at2759; -.
DR PhylomeDB; O61749; -.
DR Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR PRO; PR:O61749; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00018159; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR Gene3D; 3.30.56.30; -; 1.
DR InterPro; IPR002778; Signal_recog_particle_SRP19.
DR InterPro; IPR036521; SRP19-like_sf.
DR PANTHER; PTHR17453; PTHR17453; 1.
DR Pfam; PF01922; SRP19; 1.
DR SUPFAM; SSF69695; SSF69695; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW Signal recognition particle.
FT CHAIN 1..142
FT /note="Probable signal recognition particle 19 kDa protein"
FT /id="PRO_0000135200"
FT REGION 115..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 142 AA; 15870 MW; C82D0EF298F5579B CRC64;
MTSVASEPLS SQKRWIVIYP AYIDKKKTAK QGRKISQILA VENPTSVEIH DVLAAVGFNP
LLERTKCYPR DGERDFEVQG RVRVQLKNDD GTAKHEQKTR DEIFKMVAEM IPKLKTRQPG
YTAPSVASSS AAAAGKKNKK KK
