SRP19_DROME
ID SRP19_DROME Reviewed; 160 AA.
AC P49963; Q9VS53;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Signal recognition particle 19 kDa protein;
DE Short=SRP19;
GN Name=Srp19; ORFNames=CG4457;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Samarkand;
RX PubMed=9426007; DOI=10.1016/s0378-1119(97)00492-7;
RA Lai C.Q., Langley C.H.;
RT "A homologue of the 19 kDa signal recognition particle protein locus in
RT Drosophila melanogaster.";
RL Gene 203:59-63(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). Binds directly to 7SL RNA (By similarity). Mediates
CC binding of Srp54 to the SRP complex (By similarity).
CC {ECO:0000250|UniProtKB:J9PAS6}.
CC -!- SUBUNIT: Component of a signal recognition particle complex that
CC consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC subunits: Srp72, Srp68, Srp54, Srp19, Srp14 and Srp9.
CC {ECO:0000250|UniProtKB:P09132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09132}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P09132}.
CC -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR EMBL; U35682; AAA79181.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50575.1; -; Genomic_DNA.
DR EMBL; AY089689; AAL90427.1; -; mRNA.
DR RefSeq; NP_477135.2; NM_057787.5.
DR AlphaFoldDB; P49963; -.
DR SMR; P49963; -.
DR BioGRID; 64255; 1.
DR STRING; 7227.FBpp0076589; -.
DR PaxDb; P49963; -.
DR PRIDE; P49963; -.
DR DNASU; 38815; -.
DR EnsemblMetazoa; FBtr0076879; FBpp0076589; FBgn0015298.
DR GeneID; 38815; -.
DR KEGG; dme:Dmel_CG4457; -.
DR CTD; 6728; -.
DR FlyBase; FBgn0015298; Srp19.
DR VEuPathDB; VectorBase:FBgn0015298; -.
DR eggNOG; KOG3198; Eukaryota.
DR GeneTree; ENSGT00390000004950; -.
DR HOGENOM; CLU_064201_2_1_1; -.
DR InParanoid; P49963; -.
DR OMA; CVENPTH; -.
DR OrthoDB; 1552706at2759; -.
DR PhylomeDB; P49963; -.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR BioGRID-ORCS; 38815; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 38815; -.
DR PRO; PR:P49963; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0015298; Expressed in spermathecum and 39 other tissues.
DR ExpressionAtlas; P49963; baseline and differential.
DR Genevisible; P49963; DM.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR Gene3D; 3.30.56.30; -; 1.
DR InterPro; IPR002778; Signal_recog_particle_SRP19.
DR InterPro; IPR036521; SRP19-like_sf.
DR PANTHER; PTHR17453; PTHR17453; 1.
DR Pfam; PF01922; SRP19; 1.
DR SUPFAM; SSF69695; SSF69695; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW Signal recognition particle.
FT CHAIN 1..160
FT /note="Signal recognition particle 19 kDa protein"
FT /id="PRO_0000135201"
FT REGION 122..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 4..21
FT /note="AVPMKKNWSPSMKHNDME -> GSHEKKLEPQHETQRYGAVGT (in Ref.
FT 1; AAA79181)"
FT /evidence="ECO:0000305"
FT CONFLICT 60..61
FT /note="VL -> AV (in Ref. 1; AAA79181)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="N -> I (in Ref. 1; AAA79181)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 160 AA; 18395 MW; 8BC807BA5FEF7DA1 CRC64;
MATAVPMKKN WSPSMKHNDM ERWICIYPAY INRKKTRQEG RRLPKENCVD NPSYIEIRDV
LSVSNLQFLM ENKKYCRENS SEMEFRGRVR VQLRNVDGTL YNNDFPTRES IMLHIASKIP
QLKTRQNKSG DSYHQQSQPQ SNASGSGGGG GGKKGKGKRR
