ID   SRP19_HALVD             Reviewed;          92 AA.
AC   D4GW40;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Signal recognition particle 19 kDa protein {ECO:0000255|HAMAP-Rule:MF_00305};
DE            Short=SRP19 {ECO:0000255|HAMAP-Rule:MF_00305};
GN   Name=srp19 {ECO:0000255|HAMAP-Rule:MF_00305}; OrderedLocusNames=HVO_1109;
GN   ORFNames=C498_13198;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=DS2 / DSM 5716 / WFD11;
RX   PubMed=12029042; DOI=10.1128/jb.184.12.3260-3267.2002;
RA   Rose R.W., Pohlschroder M.;
RT   "In vivo analysis of an essential archaeal signal recognition particle in
RT   its native host.";
RL   J. Bacteriol. 184:3260-3267(2002).
RN   [4]
RP   INTERACTION WITH SRP54 AND 7S RNA, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=12364595; DOI=10.1093/nar/gkf548;
RA   Tozik I., Huang Q., Zwieb C., Eichler J.;
RT   "Reconstitution of the signal recognition particle of the halophilic
RT   archaeon Haloferax volcanii.";
RL   Nucleic Acids Res. 30:4166-4175(2002).
RN   [5]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=DS2 / WR 536 / H53;
RX   PubMed=17071750; DOI=10.1128/jb.01410-06;
RA   Yurist S., Dahan I., Eichler J.;
RT   "SRP19 is a dispensable component of the signal recognition particle in
RT   Archaea.";
RL   J. Bacteriol. 189:276-279(2007).
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Binds directly to 7S RNA and
CC       mediates binding of the 54 kDa subunit of the SRP. {ECO:0000255|HAMAP-
CC       Rule:MF_00305}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY. Archaeal SRP consists of a
CC       7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and
CC       SRP19. {ECO:0000255|HAMAP-Rule:MF_00305, ECO:0000269|PubMed:12029042}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00305,
CC       ECO:0000269|PubMed:12364595}.
CC   -!- DISRUPTION PHENOTYPE: No effect on cell growth, membrane protein
CC       insertion, protein secretion, or ribosome levels.
CC       {ECO:0000269|PubMed:17071750}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000255|HAMAP-
CC       Rule:MF_00305}.
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DR   EMBL; CP001956; ADE05093.1; -; Genomic_DNA.
DR   EMBL; AOHU01000091; ELY28201.1; -; Genomic_DNA.
DR   RefSeq; WP_004043828.1; NZ_AOHU01000091.1.
DR   AlphaFoldDB; D4GW40; -.
DR   SMR; D4GW40; -.
DR   STRING; 309800.C498_13198; -.
DR   EnsemblBacteria; ADE05093; ADE05093; HVO_1109.
DR   EnsemblBacteria; ELY28201; ELY28201; C498_13198.
DR   GeneID; 8924340; -.
DR   KEGG; hvo:HVO_1109; -.
DR   PATRIC; fig|309800.29.peg.2534; -.
DR   eggNOG; arCOG01217; Archaea.
DR   HOGENOM; CLU_169299_1_0_2; -.
DR   OMA; VIWPAYL; -.
DR   OrthoDB; 121943at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   Proteomes; UP000011532; Unassembled WGS sequence.
DR   GO; GO:0048500; C:signal recognition particle; IEA:UniProtKB-UniRule.
DR   GO; GO:0008312; F:7S RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 3.30.56.30; -; 1.
DR   HAMAP; MF_00305; SRP19; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   InterPro; IPR022938; SRP19_arc-type.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..92
FT                   /note="Signal recognition particle 19 kDa protein"
FT                   /id="PRO_0000428993"
SQ   SEQUENCE   92 AA;  10159 MW;  388A5ED4D612BA12 CRC64;
     MVENVIYPAY LDASLSRSEG RRVAQSAAVE APTVDEIAKA VQQVGYDAVI ERDKRYSREF
     ETRGRVLVNN ADDATKNDIV QAVAAYVGIL RD