SRP19_METJA
ID SRP19_METJA Reviewed; 87 AA.
AC Q58440;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Signal recognition particle 19 kDa protein {ECO:0000255|HAMAP-Rule:MF_00305};
DE Short=SRP19 {ECO:0000255|HAMAP-Rule:MF_00305};
GN Name=srp19 {ECO:0000255|HAMAP-Rule:MF_00305}; OrderedLocusNames=MJ1034;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
CC -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC proteins into the cytoplasmic membrane. Binds directly to 7S RNA and
CC mediates binding of the 54 kDa subunit of the SRP. {ECO:0000255|HAMAP-
CC Rule:MF_00305}.
CC -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC system, which is composed of SRP and FtsY. Archaeal SRP consists of a
CC 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and
CC SRP19. {ECO:0000255|HAMAP-Rule:MF_00305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00305}.
CC -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000255|HAMAP-
CC Rule:MF_00305}.
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DR EMBL; L77117; AAB99038.1; -; Genomic_DNA.
DR PIR; A64429; A64429.
DR RefSeq; WP_010870547.1; NC_000909.1.
DR PDB; 1L9A; X-ray; 2.90 A; A=1-87.
DR PDB; 1LNG; X-ray; 2.30 A; A=1-87.
DR PDB; 2V3C; X-ray; 2.50 A; A/B=1-87.
DR PDB; 3NDB; X-ray; 3.00 A; A=1-87.
DR PDB; 4XCO; X-ray; 2.90 A; A/B=1-87.
DR PDBsum; 1L9A; -.
DR PDBsum; 1LNG; -.
DR PDBsum; 2V3C; -.
DR PDBsum; 3NDB; -.
DR PDBsum; 4XCO; -.
DR AlphaFoldDB; Q58440; -.
DR SMR; Q58440; -.
DR DIP; DIP-46443N; -.
DR IntAct; Q58440; 1.
DR STRING; 243232.MJ_1034; -.
DR EnsemblBacteria; AAB99038; AAB99038; MJ_1034.
DR GeneID; 1451931; -.
DR KEGG; mja:MJ_1034; -.
DR eggNOG; arCOG01217; Archaea.
DR HOGENOM; CLU_169299_1_0_2; -.
DR InParanoid; Q58440; -.
DR OMA; VIWPAYL; -.
DR OrthoDB; 121943at2157; -.
DR PhylomeDB; Q58440; -.
DR EvolutionaryTrace; Q58440; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0048500; C:signal recognition particle; IEA:UniProtKB-UniRule.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR Gene3D; 3.30.56.30; -; 1.
DR HAMAP; MF_00305; SRP19; 1.
DR InterPro; IPR002778; Signal_recog_particle_SRP19.
DR InterPro; IPR036521; SRP19-like_sf.
DR InterPro; IPR022938; SRP19_arc-type.
DR PANTHER; PTHR17453; PTHR17453; 1.
DR Pfam; PF01922; SRP19; 1.
DR SUPFAM; SSF69695; SSF69695; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW RNA-binding; Signal recognition particle.
FT CHAIN 1..87
FT /note="Signal recognition particle 19 kDa protein"
FT /id="PRO_0000135217"
FT HELIX 5..7
FT /evidence="ECO:0007829|PDB:1LNG"
FT STRAND 9..12
FT /evidence="ECO:0007829|PDB:3NDB"
FT TURN 14..17
FT /evidence="ECO:0007829|PDB:1LNG"
FT TURN 22..24
FT /evidence="ECO:0007829|PDB:1LNG"
FT STRAND 26..28
FT /evidence="ECO:0007829|PDB:1LNG"
FT HELIX 31..40
FT /evidence="ECO:0007829|PDB:1LNG"
FT STRAND 46..48
FT /evidence="ECO:0007829|PDB:1LNG"
FT HELIX 54..56
FT /evidence="ECO:0007829|PDB:1LNG"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:1LNG"
FT HELIX 72..83
FT /evidence="ECO:0007829|PDB:1LNG"
SQ SEQUENCE 87 AA; 10352 MW; 0BF272957E69CBE8 CRC64;
MIIWPSYIDK KKSRREGRKV PEELAIEKPS LKDIEKALKK LGLEPKIYRD KRYPRQHWEI
CGCVEVDYKG NKLQLLKEIC KIIKGKN
