ID   SRP19_MOUSE             Reviewed;         144 AA.
AC   Q9D7A6;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Signal recognition particle 19 kDa protein;
DE            Short=SRP19;
GN   Name=Srp19;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC       ribonucleoprotein complex that mediates the cotranslational targeting
CC       of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC       (By similarity). Binds directly to 7SL RNA (By similarity). Mediates
CC       binding of SRP54 to the SRP complex (By similarity).
CC       {ECO:0000250|UniProtKB:J9PAS6}.
CC   -!- SUBUNIT: Component of a signal recognition particle complex that
CC       consists of a 7SL RNA molecule of 300 nucleotides and 6 protein
CC       subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9 (By similarity).
CC       Interacts with IPO5, IPO7, IPO8, KPNB1 and TNPO1. Interactions with
CC       IPO8 and TNPO1 may be involved in SRP19 import into the nucleus (By
CC       similarity). {ECO:0000250|UniProtKB:P09132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09132}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:P09132}. Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:P09132}. Note=Although the signal recognition
CC       particle complex acts in the cytoplasm, it assembles at least in part
CC       in the nucleus and/or the nucleolus. SRP19 nuclear import may be
CC       mediated by IPO8/Imp8 and TPNO1/Trn. {ECO:0000250|UniProtKB:P09132}.
CC   -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR   EMBL; AK009412; BAB26271.1; -; mRNA.
DR   CCDS; CCDS37757.1; -.
DR   AlphaFoldDB; Q9D7A6; -.
DR   SMR; Q9D7A6; -.
DR   STRING; 10090.ENSMUSP00000072386; -.
DR   PhosphoSitePlus; Q9D7A6; -.
DR   EPD; Q9D7A6; -.
DR   jPOST; Q9D7A6; -.
DR   MaxQB; Q9D7A6; -.
DR   PaxDb; Q9D7A6; -.
DR   PeptideAtlas; Q9D7A6; -.
DR   PRIDE; Q9D7A6; -.
DR   ProteomicsDB; 257363; -.
DR   MGI; MGI:1913634; Srp19.
DR   eggNOG; KOG3198; Eukaryota.
DR   InParanoid; Q9D7A6; -.
DR   PhylomeDB; Q9D7A6; -.
DR   Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   ChiTaRS; Srp19; mouse.
DR   PRO; PR:Q9D7A6; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9D7A6; protein.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0016604; C:nuclear body; ISO:MGI.
DR   GO; GO:0005730; C:nucleolus; ISO:MGI.
DR   GO; GO:0048500; C:signal recognition particle; ISO:MGI.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; ISO:MGI.
DR   GO; GO:0008312; F:7S RNA binding; ISO:MGI.
DR   GO; GO:0043022; F:ribosome binding; ISO:MGI.
DR   GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR   Gene3D; 3.30.56.30; -; 1.
DR   InterPro; IPR002778; Signal_recog_particle_SRP19.
DR   InterPro; IPR036521; SRP19-like_sf.
DR   PANTHER; PTHR17453; PTHR17453; 1.
DR   Pfam; PF01922; SRP19; 1.
DR   SUPFAM; SSF69695; SSF69695; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..144
FT                   /note="Signal recognition particle 19 kDa protein"
FT                   /id="PRO_0000135198"
FT   REGION          118..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  16191 MW;  223755250CB28771 CRC64;
     MACSAARPPA DQDRFIFIYP AYLNNKKTIA EGRRIPISKA VENPTATEIQ DVCSAVGLNA
     FLEKNKMYSR EWNRDVQFRG RVRVQLKQED GSLCLVQFPS RKSVMLYVAE MIPKLKTRTQ
     KSGGADPILQ QGEGSKKGKG KKKK