SRP19_ORYSJ
ID SRP19_ORYSJ Reviewed; 136 AA.
AC P49964; Q0DCD9; Q5Z9Y1;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Signal recognition particle 19 kDa protein;
DE Short=SRP19;
GN Name=SRP19; OrderedLocusNames=Os06g0342100, LOC_Os06g23430;
GN ORFNames=P0428A03.35, P0459H02.12;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF ARG-31 AND ARG-32.
RC STRAIN=cv. Nipponbare; TISSUE=Callus;
RX PubMed=9225861; DOI=10.1023/a:1005834026743;
RA Chittenden K., Gowda K., Black S.D., Zwieb C.;
RT "Interaction of rice and human SRP19 polypeptides with signal recognition
RT particle RNA.";
RL Plant Mol. Biol. 34:507-515(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). Binds directly to 7SL RNA (By similarity). Mediates
CC binding of SRP54 to the SRP complex (By similarity).
CC {ECO:0000250|UniProtKB:J9PAS6}.
CC -!- SUBUNIT: Component of a signal recognition particle complex that
CC consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
CC {ECO:0000250|UniProtKB:P09132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09132}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:P09132}.
CC -!- SIMILARITY: Belongs to the SRP19 family. {ECO:0000305}.
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DR EMBL; U19030; AAB65810.1; -; mRNA.
DR EMBL; AP003506; BAD61555.1; -; Genomic_DNA.
DR EMBL; AP003572; BAD61629.1; -; Genomic_DNA.
DR EMBL; AP008212; BAF19484.1; -; Genomic_DNA.
DR EMBL; AP014962; BAS97630.1; -; Genomic_DNA.
DR EMBL; AK059915; BAG87210.1; -; mRNA.
DR PIR; T03292; T03292.
DR RefSeq; XP_015641044.1; XM_015785558.1.
DR AlphaFoldDB; P49964; -.
DR SMR; P49964; -.
DR STRING; 4530.OS06T0342100-01; -.
DR PaxDb; P49964; -.
DR PRIDE; P49964; -.
DR EnsemblPlants; Os06t0342100-01; Os06t0342100-01; Os06g0342100.
DR GeneID; 4340957; -.
DR Gramene; Os06t0342100-01; Os06t0342100-01; Os06g0342100.
DR KEGG; osa:4340957; -.
DR eggNOG; KOG3198; Eukaryota.
DR HOGENOM; CLU_064201_1_2_1; -.
DR InParanoid; P49964; -.
DR OMA; CVENPTH; -.
DR OrthoDB; 1552706at2759; -.
DR Proteomes; UP000000763; Chromosome 6.
DR Proteomes; UP000059680; Chromosome 6.
DR Genevisible; P49964; OS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IBA:GO_Central.
DR GO; GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IBA:GO_Central.
DR Gene3D; 3.30.56.30; -; 1.
DR InterPro; IPR002778; Signal_recog_particle_SRP19.
DR InterPro; IPR036521; SRP19-like_sf.
DR PANTHER; PTHR17453; PTHR17453; 1.
DR Pfam; PF01922; SRP19; 1.
DR SUPFAM; SSF69695; SSF69695; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding;
KW Signal recognition particle.
FT CHAIN 1..136
FT /note="Signal recognition particle 19 kDa protein"
FT /id="PRO_0000135203"
FT REGION 106..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 31
FT /note="R->Q: Abolishes RNA binding."
FT /evidence="ECO:0000269|PubMed:9225861"
FT MUTAGEN 32
FT /note="R->Q: Abolishes RNA binding."
FT /evidence="ECO:0000269|PubMed:9225861"
SQ SEQUENCE 136 AA; 14922 MW; 65D3B91967F3D638 CRC64;
MDGGDLRSSI KKWNVIYPVY LNSKKTVAEG RRIASGKACP DPTCVEIADC CSHLKIPHAI
ELDKAYPRDF FQVGRVRVQL KKDDGSPVNP AIKTKKQLMI QIAELVPKHH GRTKKQEPAA
SSTAGTSKGK GGKKKK
