ID   SRP54_ASPNG             Reviewed;         534 AA.
AC   Q00179;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Signal recognition particle 54 kDa protein homolog;
GN   Name=srpA;
OS   Aspergillus niger.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=5061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8566805; DOI=10.1016/0378-1119(95)00669-9;
RA   Thompson S.A., Golightly E.J., Yaver D.S.;
RT   "Nucleotide sequence of the Aspergillus niger srpA gene.";
RL   Gene 167:337-338(1995).
CC   -!- FUNCTION: Binds to the signal sequence of presecretory protein when
CC       they emerge from the ribosomes and transfers them to TRAM
CC       (translocating chain-associating membrane protein).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: Has a two domain structure: the G-domain binds GTP; the M-
CC       domain binds the 7S RNA in presence of SRP19 and also binds the signal
CC       sequence.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; L38317; AAB04946.1; -; Genomic_DNA.
DR   PIR; JC4572; JC4572.
DR   AlphaFoldDB; Q00179; -.
DR   SMR; Q00179; -.
DR   STRING; 5061.CADANGAP00008025; -.
DR   VEuPathDB; FungiDB:An09g06320; -.
DR   VEuPathDB; FungiDB:ASPNIDRAFT2_1115095; -.
DR   VEuPathDB; FungiDB:ATCC64974_8040; -.
DR   VEuPathDB; FungiDB:M747DRAFT_287874; -.
DR   eggNOG; KOG0780; Eukaryota.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:EnsemblFungi.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:EnsemblFungi.
DR   Gene3D; 1.10.260.30; -; 1.
DR   Gene3D; 1.20.120.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00306; SRP54; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036891; Signal_recog_part_SRP54_M_sf.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004125; Signal_recog_particle_SRP54_M.
DR   InterPro; IPR036225; SRP/SRP_N.
DR   InterPro; IPR022941; SRP54.
DR   InterPro; IPR006325; SRP54_euk.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   PANTHER; PTHR11564; PTHR11564; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   Pfam; PF02978; SRP_SPB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF47446; SSF47446; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01425; SRP54_euk; 1.
DR   PROSITE; PS00300; SRP54; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..534
FT                   /note="Signal recognition particle 54 kDa protein homolog"
FT                   /id="PRO_0000101199"
FT   REGION          1..296
FT                   /note="G-domain"
FT   REGION          297..534
FT                   /note="M-domain"
FT   BINDING         109..116
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         191..195
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         249..252
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   534 AA;  57117 MW;  1B21E3A48CCB3BA6 CRC64;
     MVLQDLGRRI NAAVNDLTRS NNLDEKQAFD DMIKEICAAL LSADVNVRLV QSLRKSIKSS
     VNFASLPPAV NKKRLIQKAV FDELVSLVDP HAEPFRPKKG RSNVIMFVGL QGAGKTTTCT
     KLARHYQMRG FKTALVCADT FRAGAFDQLK QNATKAKIPY YGSLTQTDPA IVAAEGVAKF
     KKERFEIIIV DTSGRHKQEE ELFTEMTQIQ TAVTPDQTIL VLDSTIGQAA EAQSSAFKAT
     ADFGAIIITK TDGHAAGGGA ISAVAATHTP IIYLGTGEHL MDLERFEPKA FIQKLLGMGD
     MAGLVEHVQA VTKDSASAKE TYKHISEGIY TLRDFRENIT SIMKMGPLSK LSGMIPGLSN
     LTAGLDDEDG SMKLRRMIYI FDSMTAAELD GDGKMFVEQP SRMVRIACGS GTTVREVEDL
     LSQHRMMAGM AKRVGGQKKQ MQRAQNMLKG GNKEQQLAAM QKRMAAMGGA GGGGFPGMPG
     MGDMAKMMQM LQGQGGGGGG GLPGLGGMDL QSMMSQMSGL MGGGGGGGGR GRGR