ID   SRP54_CANAX             Reviewed;         556 AA.
AC   O42816;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Signal recognition particle 54 kDa protein homolog;
GN   Name=SRP54;
OS   Candida albicans (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=5476;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=B2630;
RA   Hosking S.L., Stirling C.J., Egerton M.;
RT   "Isolation of the SRP54 homolog from the pathogenic yeast, Candida
RT   albicans.";
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the signal sequence of presecretory protein when
CC       they emerge from the ribosomes and transfers them to TRAM
CC       (translocating chain-associating membrane protein).
CC   -!- SUBUNIT: Fungal signal recognition particle consists of a 7S RNA
CC       molecule (SCR1) and at least seven protein subunits: SRP72, SRP68,
CC       SRP54, SEC65, SRP21, SRP14 and SRP7. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: Has a two domain structure: the G-domain binds GTP; the M-
CC       domain binds the 7S RNA in presence of SRP19 and also binds the signal
CC       sequence.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ222805; CAA10999.1; -; mRNA.
DR   AlphaFoldDB; O42816; -.
DR   SMR; O42816; -.
DR   VEuPathDB; FungiDB:CAWG_01464; -.
DR   VEuPathDB; FungiDB:CR_01110W_A; -.
DR   GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
DR   GO; GO:0008312; F:7S RNA binding; IEA:EnsemblFungi.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:EnsemblFungi.
DR   Gene3D; 1.10.260.30; -; 1.
DR   Gene3D; 1.20.120.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_00306; SRP54; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR036891; Signal_recog_part_SRP54_M_sf.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004125; Signal_recog_particle_SRP54_M.
DR   InterPro; IPR036225; SRP/SRP_N.
DR   InterPro; IPR022941; SRP54.
DR   InterPro; IPR006325; SRP54_euk.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   PANTHER; PTHR11564; PTHR11564; 1.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   Pfam; PF02978; SRP_SPB; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF47446; SSF47446; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01425; SRP54_euk; 1.
DR   PROSITE; PS00300; SRP54; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTP-binding; Nucleotide-binding; Ribonucleoprotein; RNA-binding;
KW   Signal recognition particle.
FT   CHAIN           1..556
FT                   /note="Signal recognition particle 54 kDa protein homolog"
FT                   /id="PRO_0000101200"
FT   REGION          1..312
FT                   /note="G-domain"
FT   REGION          313..556
FT                   /note="M-domain"
FT   REGION          450..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         125..132
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         207..211
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         265..268
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   556 AA;  60701 MW;  0EA14A8FE7B922CF CRC64;
     MVLADLGSRL RGALSSVESG SDDEIQQMIK DICSALLESD VNVKLVAKLR GNIKNKIDES
     NVSKETSAMN KRKKLQKIIF DELCALVDSN VEPPKPKKLS TSTKTINGKK VRLSKESSHV
     IMFVGLQGAG KTTSCTKLAV YYKKRGFKVG LVCADTFRAG AFDQLKQNAI KANIPYYGSY
     LEPDPVKIAF EGVQKFKQEK FDIIIVDTSG RHRQEEQLFT EMVQIGEAVQ PTQTIMVMDG
     SIGQAAESQA RAFKESSNFG SIILTKMDGH AKGGGAISAV AATKTPIVFI GTGEHVGDLE
     IFKPTTFISK LLGIGDIQGL IEHVQSLNLH QDEGHKQTIE HIKEGKFTLR DFQNQMNNFL
     KMGPLTNIAS MIPGLSNIMS QVGDEETSKK IKNMIYIMDS MTTKELECDG RIFIKEPSRI
     VRVARGSGCA VVEVEMILQQ HRMMSTMAKS AMAAQGGQPG QPGNPMANNP QMQRMMQQAQ
     SNPNFMQQAM NMLGGAGGGA GGAGGLAGMM NNPAMMQQAQ QMMRSNPQMM QQAQQMMKNP
     GMMQKMMQQF GGMGGM