SRP68_CAEEL
ID SRP68_CAEEL Reviewed; 622 AA.
AC Q20822;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Signal recognition particle subunit SRP68 {ECO:0000305};
DE Short=SRP68;
DE AltName: Full=Probable signal recognition particle 68 kDa protein;
GN Name=srpa-68 {ECO:0000312|WormBase:F55C5.8};
GN ORFNames=F55C5.8 {ECO:0000312|WormBase:F55C5.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER)
CC (By similarity). The SRP complex interacts with the signal sequence in
CC nascent secretory and membrane proteins and directs them to the
CC membrane of the ER (By similarity). The SRP complex targets the
CC ribosome-nascent chain complex to the SRP receptor (SR), which is
CC anchored in the ER, where SR compaction and GTPase rearrangement drive
CC cotranslational protein translocation into the ER (By similarity).
CC Binds the signal recognition particle RNA (7SL RNA), srpa-72 binds to
CC this complex subsequently (By similarity). The SRP complex possibly
CC participates in the elongation arrest function (By similarity).
CC {ECO:0000250|UniProtKB:P38687, ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- SUBUNIT: Heterodimer with srpa-72 (By similarity). Srpa-68/srpa-72
CC heterodimer formation is stabilized by the presence of 7SL RNA (By
CC similarity). Component of a signal recognition particle (SRP) complex
CC that consists of a 7SL RNA molecule of 300 nucleotides and six protein
CC subunits: srpa-72, srpa-68, SRP54, F37F2.2/SRP19, F25G6.8/SRP14 and
CC ZK512.4/SRP9 (By similarity). Within the SRP complex, interacts (via C-
CC terminus) with srpa-72 (via N-terminus) (By similarity).
CC {ECO:0000250|UniProtKB:Q00004, ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UHB9}.
CC Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9UHB9}. Endoplasmic
CC reticulum {ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- DOMAIN: The N-terminus is required for RNA-binding.
CC {ECO:0000250|UniProtKB:Q9UHB9}.
CC -!- SIMILARITY: Belongs to the SRP68 family. {ECO:0000305}.
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DR EMBL; Z78198; CAB01573.1; -; Genomic_DNA.
DR PIR; T22716; T22716.
DR RefSeq; NP_506083.1; NM_073682.4.
DR AlphaFoldDB; Q20822; -.
DR SMR; Q20822; -.
DR BioGRID; 44709; 5.
DR STRING; 6239.F55C5.8; -.
DR EPD; Q20822; -.
DR PaxDb; Q20822; -.
DR PeptideAtlas; Q20822; -.
DR EnsemblMetazoa; F55C5.8.1; F55C5.8.1; WBGene00010097.
DR GeneID; 179686; -.
DR KEGG; cel:CELE_F55C5.8; -.
DR UCSC; F55C5.8; c. elegans.
DR CTD; 179686; -.
DR WormBase; F55C5.8; CE20875; WBGene00010097; srpa-68.
DR eggNOG; KOG2460; Eukaryota.
DR GeneTree; ENSGT00390000011856; -.
DR HOGENOM; CLU_018649_0_1_1; -.
DR InParanoid; Q20822; -.
DR OMA; DERFIHI; -.
DR OrthoDB; 1019762at2759; -.
DR PhylomeDB; Q20822; -.
DR Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR PRO; PR:Q20822; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00010097; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IBA:GO_Central.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
DR GO; GO:0005047; F:signal recognition particle binding; IBA:GO_Central.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR CDD; cd15481; SRP68-RBD; 1.
DR Gene3D; 1.10.3450.40; -; 1.
DR InterPro; IPR026258; SRP68.
DR InterPro; IPR034652; SRP68-RBD.
DR InterPro; IPR038253; SRP68_N_sf.
DR PANTHER; PTHR12860; PTHR12860; 1.
DR Pfam; PF16969; SRP68; 1.
DR PIRSF; PIRSF038995; SRP68; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Endoplasmic reticulum; Nucleus; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Signal recognition particle.
FT CHAIN 1..622
FT /note="Signal recognition particle subunit SRP68"
FT /id="PRO_0000135229"
FT REGION 576..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 70574 MW; A7B8808E46169636 CRC64;
MTNDVEMKSE TEELPPFPTV HILQVVKDAQ QQHGLRHGDY ARYRKYCAAK LERMRKALKF
TNSHNCQKKR KAKFVKKWLS VESVQNVQFL NFGIFESERR YAEAMIDKIT LEDNPEKSRK
KFSMINSLRK AVLHATNLEK IVQESERFDA PTKLEAQAYA AWMRGMCSFE SRNWQKASES
LKLAKTVYEK LAEATNNTTL SSIFKGRCRE IQPQLRLCEF NIAESPGAVG TMTELMELRM
QMGEGGDSSV DKLISEMRAS ATSAEVVTIE WGGAKSTVDD EKAKQVVQEW KQTEVELAQC
QTPKEKMALF EKATADTRDA IDRISDIIRR KSSENADTTV LQSIKAYLEF LKMNGTASRY
LAIIDNTKSE KKSKPQDLLR LYDSVIEIYK EVAEIPGADH DKNLIQAFEV KVEYYRAFRC
FYMASSYSAL HKYSEAAALF DRTVSRVQDA EGKLKKLKSS SFITNETQSS LNELRSEVES
AKVTVRAARL ASAAGDVKTD SELAKIIDKR PLLETVNEWR QWDVRNSLKD KKTIPVASLP
PAFIPMPNKP IFFDLANFHL TMPNVDDRLE KLQKDRDATP KKAAKGSSAA AASSKTSNQE
EEEQQGLTGM LSGWKKSFWG NK
